Physiopathology of foreign body infections

Role of the Staphylococcus epidermidis slime layer in experimental tunnel tract infections

“…The high frequency of abscess formation in sham-operated mice was unexpected. Both slime-producing and non-slimeproducing organisms produced abscesses within the surgical field, consistent with recent studies showing staphylococcal adherence to host proteins, such as fibronectin and fibrinogen, that are involved in wound healing (15,19,24). This is supported by clinical studies of humans describing S. epidermidis infections of surgical wounds in the absence of a foreign body, such as mediastinitis following open heart surgery (13,16).…”

Role of the Staphylococcus epidermidis slime layer in experimental tunnel tract infections

“…The high frequency of abscess formation in sham-operated mice was unexpected. Both slime-producing and non-slimeproducing organisms produced abscesses within the surgical field, consistent with recent studies showing staphylococcal adherence to host proteins, such as fibronectin and fibrinogen, that are involved in wound healing (15,19,24). This is supported by clinical studies of humans describing S. epidermidis infections of surgical wounds in the absence of a foreign body, such as mediastinitis following open heart surgery (13,16).…”

Tissue Compatibility of Biomaterials: Benefits and Problems of Skin Biointegration

“…Bacteria in biofilms cannot be eradicated by antibiotics and are resistant to normal immunological defence mechanisms 30 . In addition, compounding the problem of biofilm, the inherent pathogenicity of endogenous bacteria, such as Staphylococcus epidermidis is increased by the very presence of foreign bodies 31 …”

Fibrinogen adsorption and host tissue responses to plasma functionalized surfaces

“…[13][14][15] It is believed that the surface properties of biomaterials, including chemistry, wettability, domain composition, and morphology, may influence protein adsorption and subsequent cellular responses to biomaterial implants. Thus significant research efforts have been focused on modifying surface physical and chemical properties to generate surfaces with better biocompatibility and/or blood compatibility.…”

Role of the Staphylococcus epidermidis slime layer in experimental tunnel tract infections

“…The high frequency of abscess formation in sham-operated mice was unexpected. Both slime-producing and non-slimeproducing organisms produced abscesses within the surgical field, consistent with recent studies showing staphylococcal adherence to host proteins, such as fibronectin and fibrinogen, that are involved in wound healing (15,19,24). This is supported by clinical studies of humans describing S. epidermidis infections of surgical wounds in the absence of a foreign body, such as mediastinitis following open heart surgery (13,16).…”

Tissue Compatibility of Biomaterials: Benefits and Problems of Skin Biointegration

“…Bacteria in biofilms cannot be eradicated by antibiotics and are resistant to normal immunological defence mechanisms 30 . In addition, compounding the problem of biofilm, the inherent pathogenicity of endogenous bacteria, such as Staphylococcus epidermidis is increased by the very presence of foreign bodies 31 …”

Fibrinogen adsorption and host tissue responses to plasma functionalized surfaces

“…[13][14][15] It is believed that the surface properties of biomaterials, including chemistry, wettability, domain composition, and morphology, may influence protein adsorption and subsequent cellular responses to biomaterial implants. Thus significant research efforts have been focused on modifying surface physical and chemical properties to generate surfaces with better biocompatibility and/or blood compatibility.…”

Role of the Staphylococcus epidermidis slime layer in experimental tunnel tract infections

“…The high frequency of abscess formation in sham-operated mice was unexpected. Both slime-producing and non-slimeproducing organisms produced abscesses within the surgical field, consistent with recent studies showing staphylococcal adherence to host proteins, such as fibronectin and fibrinogen, that are involved in wound healing (15,19,24). This is supported by clinical studies of humans describing S. epidermidis infections of surgical wounds in the absence of a foreign body, such as mediastinitis following open heart surgery (13,16).…”

Tissue Compatibility of Biomaterials: Benefits and Problems of Skin Biointegration

“…Bacteria in biofilms cannot be eradicated by antibiotics and are resistant to normal immunological defence mechanisms 30 . In addition, compounding the problem of biofilm, the inherent pathogenicity of endogenous bacteria, such as Staphylococcus epidermidis is increased by the very presence of foreign bodies 31 …”

Fibrinogen adsorption and host tissue responses to plasma functionalized surfaces

“…[13][14][15] It is believed that the surface properties of biomaterials, including chemistry, wettability, domain composition, and morphology, may influence protein adsorption and subsequent cellular responses to biomaterial implants. Thus significant research efforts have been focused on modifying surface physical and chemical properties to generate surfaces with better biocompatibility and/or blood compatibility.…”