Physiopathologie des lésions gastro-duodénales induites par les anti-inflammatoires non stéroïdiens

Lamarque, Dominique

doi:10.1016/s0399-8320(04)95275-x

Cited by 15 publications

(6 citation statements)

References 99 publications

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“…Increased oxidative stress and ROS production are pathogenic mechanisms of both models [4–9, 12]. Nevertheless, the key mechanism of NSAID-induced gastric ulceration results from the irreversible and nonselective inhibition of COX activity, which interferes with the synthesis from PG, triggering the effects derived of PG depletion, and shuttles the arachidonic acid metabolism towards the lipoxygenase pathway, increasing the formation of vasoconstrictor leukotrienes (LTs) [6, 7, 10, 11]. …”

Section: Resultsmentioning

confidence: 99%

Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers

Cuevas

Calzado

Guerra

et al. 2011

Advances in Pharmacological Sciences

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Effects of GSE and vitamins C and E on aspirin- and ethanol-induced gastric ulcer and associated increases of lipid peroxidation in rats were compared. Two experiments were conducted. Rats were randomized into eight groups: a negative control and seven groups that received aspirin or ethanol for ulcer induction: one positive control (vehicle) and six with VC, VE, or GSE (25 and 250 mg/kg). Ulcer indexes and gastric levels of malondialdehyde (MDA) were quantified. VC, VE, and GSE (25 and 250 mg/kg) decreased aspirin, and ethanol-induced ulcers and MDA values compared with positive control group. The magnitude of aspirin ulcer reduction was comparable for all treatments, and MDA decrease with GSE was higher than with VC and tended to be greater, albeit none significantly, than with VE. GSE was more effective than VC and VE for lowering the ethanol ulcers, while the decrease of MDA levels with GSE was greater than with VC, but comparable to that achieved with VE. GSE protected against ethanol-induced gastric ulcers more effectively than VC or VE, while its protection against aspirin ulcers was comparable for all treatments. GSE produced the greatest reductions of gastric MDA in both models.

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Section: Resultsmentioning

confidence: 99%

Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers

Cuevas

Calzado

Guerra

et al. 2011

Advances in Pharmacological Sciences

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“…Inflammation produces local pain and gastric discomfort when in the clinical evaluation. The gastric inflammation produces several oxygen free radicals involved in the attack to mucosal protection in the stomach [50].…”

Section: Discussionmentioning

confidence: 99%

Antiulcerogenic Effect of Brazilian Propolis Formulation in Mice

Paulino¹,

Coutinho²,

Coutinho³

et al. 2015

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Propolis is a natural resin used around the world to treatment of several diseases. We evaluated the effect of Brazilian propolis (P1) in guinea pig isolated trachea in vitro contracted with histamine, in paw oedema induced by histamine in mice and anti-ulcerogenic effect of propolis formulation in mice. We used a P1 extract from South of Brazil to produce a formulation containing sodium bicarbonate and propolis dry extract (2%). In the guinea pig trachea Brazilian propolis extract (10 µg/mL) produced a non-significant inhibition in the cumulative response curve for histamine. However, the dose of 100 µg/mL shown had a significant inhibitory effect on the contraction induced by histamine (51% ± 5%). In the mouse paw oedema induced by intraplantar injection of histamine (50 μg/paw), the results showed that the treatment of the mice with P1 (10 or 100 mg/Kg (p.o) or 1 or 10 mg/Kg (i.p)), 0.5 h beforehand, significantly inhibited the paw oedema with maximal inhibition (MI) of 25% or 42% by p.o. route or 22% or 37% by i.p. route, respectively. Finally we have pre-treated mice with P1 formulation (20 mg/Kg or 40 mg/Kg, p.o, one time) or vehicle (powder) in animals submitted to diclofenac-induced ulcer, after 8 h P1 formulation inhibited of 43% or 83% of ulcers scores, respectively. Results showed that P1 formulation inhibited the ulcerogenic effect induced by diclofenac. Results suggested also, at least in part, the antiulcerogenic effect of formulation containing standardized extract of propolis can be due to the antagonistic action on the histaminergic system.

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“…Despite its therapeutics benefits, it’s known to induce gastric ulcer in both human and animals [9] , [10] . The pathogenesis of aspirin-induced gastric ulceration includes the aspirin blocking the activities of the cyclooxygenase enzymes (COX-1 and COX-2) hence leading to reduced mucus and bicarbonate secretion, decreased mucosal blood flow, impaired platelet aggregation, alteration of microvascular structures leading to epithelia damage, increased leukocyte adherence and increased production of reactive oxygen species (ROS), increased lipid peroxidation and neutrophil infiltration as well as decreased antioxidant enzymes [11] , [12] , [13] .…”

Section: Introductionmentioning

confidence: 99%

Gastro-protective effect of methanol extract of Vernonia amygdalina (del.) leaf on aspirin-induced gastric ulcer in Wistar rats

et al. 2017

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Physiopathologie des lésions gastro-duodénales induites par les anti-inflammatoires non stéroïdiens

Cited by 15 publications

References 99 publications

Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers

Effects of Grape Seed Extract, Vitamin C, and Vitamin E on Ethanol- and Aspirin-Induced Ulcers

Antiulcerogenic Effect of Brazilian Propolis Formulation in Mice

Gastro-protective effect of methanol extract of Vernonia amygdalina (del.) leaf on aspirin-induced gastric ulcer in Wistar rats

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