2015
DOI: 10.1113/jphysiol.2014.282665
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Abstract: Most nations of the world are undergoing rapid and dramatic population ageing, which presents great socio-economic challenges, as well as opportunities, for individuals, families, governments and societies. The prevailing biomedical strategy for reducing the healthcare impact of population ageing has been 'compression of morbidity' and, more recently, to increase healthspan, both of which seek to extend the healthy period of life and delay the development of chronic diseases and disability until a brief period… Show more

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Cited by 211 publications
(187 citation statements)
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References 202 publications
(437 reference statements)
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“…Because these factors can be modified by changes in lifestyle, e.g. diet [65] and exercise [6569], or by presently available drugs, e.g. those that reduce the impact of Ang II signaling [31, 3637,39], there is an urgency to incorporate cardiovascular aging into clinical medicine.…”
Section: Clinical Implications Of Cardiovascular Agingmentioning
confidence: 99%
See 1 more Smart Citation
“…Because these factors can be modified by changes in lifestyle, e.g. diet [65] and exercise [6569], or by presently available drugs, e.g. those that reduce the impact of Ang II signaling [31, 3637,39], there is an urgency to incorporate cardiovascular aging into clinical medicine.…”
Section: Clinical Implications Of Cardiovascular Agingmentioning
confidence: 99%
“…Thus, although age is the dominant risk factor for cardiovascular diseases [1] (Fig. 1) and some effects of aging can be modified [31, 35, 3637, 6569], most of the research efforts on prevention of these diseases have ignored focusing on the effects of aging of the arterial wall, and, instead, have focused on development of interventions that target other “traditional” cardiovascular risk factors (such as hypertension and hyperlipidemia).…”
Section: Clinical Implications Of Cardiovascular Agingmentioning
confidence: 99%
“…Recent research in geroscience is beginning to provide insights into how fundamental biologic processes of aging, such as inflammation, oxidative stress, tissue senescence including the immune system, and dysregulation of a variety of homeostatic mechanisms, could be delayed to extend 'healthspan', i.e. the healthy period of life and delay the development of chronic diseases and disability [6]. Infectious diseases in seniors often accelerate the decline in their functional status.…”
Section: Higher Risk Of Infectious Diseases In the Elderlymentioning
confidence: 99%
“…The production of anti-inflammatory mediators in response to this chronic inflammation has been associated with more successful ageing. Current efforts to increase health span centre on slowing the fundamental biological processes of aging such as inflammation/oxidative stress, increased senescence, mitochondrial dysfunction, impaired proteostasis and reduced stress resistance [6].…”
Section: Higher Risk Of Infectious Diseases In the Elderlymentioning
confidence: 99%
“…Interventions that target the molecular mechanisms of aging have the potential to increase both life span and health span, which can be defined as the period of life free from chronic disease and disability 9,17 . In fact, accumulating scientific evidence from studies conducted in various organisms and species suggests that targeting aging will not just postpone chronic diseases but also prevent multiple age-associated metabolic alterations while extending healthy lifespan 9,17,18,19,20 . Among the most promising strategies that could be tested in humans for their effects on healthspan, are: (i) dietary interventions mimicking chronic dietary restriction (periodic fasting mimicking diets, protein restriction, etc.…”
mentioning
confidence: 99%