Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects

Sone, Hirohito; Shimano, Hitoshi; Ebinuma, Hiroyuki; Takahashi, Akimitsu; Yano, Yoshihiro; Iida, Kaoruko; Suzuki, Hiroaki; Toyoshima, Hideo; Kawakami, Yasushi; Okuda, Yukichi; Noguchi, Yuichi; Ushizawa, Koji; Saito, Kazunori; Yamada, Nobuhiro

doi:10.1016/s0026-0495(03)00153-7

Cited by 46 publications

(55 citation statements)

References 25 publications

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“…However, a positive correlation was also observed with plasma [mannose] and plasma [glucose] and [fructosamine], respectively suggesting that plasma mannose measurement could potentially play a supplementary role in the diagnosis and screening of diabetic dogs. In spite of the higher [mannose] present in diabetic dogs, plasma mannose levels were found to be about 8-9% of plasma glucose levels, in both normal and diabetic animals, which is similar to previously reported results (Sone et al 2003). Moreover, no trend differences have been observed with serum mannose levels based between carnivores, herbivores, and omnivores thus indicating that mannose is a normal component of the blood of higher animals (Alton et al 1998).…”

Section: Discussionsupporting

confidence: 89%

“…In this study, it was determined that there is a positive correlation between circulating and fasting mannose and glucose levels in control and diabetic dogs. Also, circulating [mannose] was increased in diabetic dogs confirming similar findings in humans (Sone et al 2003 Analyzing fructosamine levels can indirectly assess blood sugar in dogs (Reusch et al 1993). Fructosamines are glycated proteins which are also known as ketoamines.…”

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

“…Instead, the main source is the liver and/or other tissues which synthesize it (Sone et al 2003). Mannose can be synthesized from glucose via a cellular enzymatic pathway involving the phosphorylation of hexose intermediates (Sone et al 2003). The glucose can either be in the form of ingested glucose or as a breakdown product from hepatic glycogen (Taguchi et al 2003;Taguchi et al 2005).…”

Section: Discussionmentioning

confidence: 99%

“…It has been speculated that the main source of circulating mannose is not from the diet since the average diet does not contain enough mannose to even satisfy the body's need for physiological glycosylation. Instead, the main source is the liver and/or other tissues which synthesize it (Sone et al 2003). Mannose can be synthesized from glucose (Pitkänen 1996) either in the form of ingested glucose or by breaking down hepatic glycogen (Taguchi et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of plasma mannose concentrations in healthy and diabetic dogs

et al. 2008

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Circulating levels of monosaccharides can act as a reflection of systemic glucose/ energy metabolism. Characteristic changes observed in these levels can be seen in patients with diabetes and other metabolic disorders. There have been a few reports describing the significance of mannose metabolism as an energy source under physiological and pathological conditions. However, the relationship between circulating levels of mannose and the pathophysiology of diabetes mellitus are unknown in dogs. This study examined circulating levels of mannose between healthy control and diabetic dogs and evaluated the clinical significance of mannose levels in dogs. Diabetic dogs demonstrated a higher circulating level of mannose in comparison to normal healthy control dogs. Plasma mannose was positively correlated with plasma glucose and fructosamine, respectively. Interestingly, plasma mannose levels were affected by plasma insulin levels. In the context of feeding and glucose tolerance tests, plasma mannose levels responded to changes in circulating insulin levels. Circulating plasma mannose levels decreased after feeding in both control and diabetic animals in spite of observed insulin level differences. However, when glucose tolerance tests were given, a positive correlation between mannose levels and insulin levels was observed. Therefore, plasma mannose levels obtained via glucose tolerance testing may be used as a new diagnostic method for evaluating insulin resistance or deficiency in diabetic dogs.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical significance of plasma mannose concentrations in healthy and diabetic dogs

et al. 2008

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Exploring the Diversity of Sugar Compounds in Healthy, Prediabetic, and Diabetic Volunteers

Mack

Ferrario

Weinert

et al. 2020

Molecular Nutrition Food Res

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Scope: Diabetes is thought to primarily represent a disturbance of carbohydrate metabolism; however, population studies employing metabolomics have mainly identified plasma amino acids and lipids, or their products, as biomarkers. In this pilot study, the aim is to analyze a wide spectrum of sugar compounds in the fasting state and during an oral glucose tolerance test (OGTT) in healthy, prediabetic, and type 2 diabetic volunteers. Methods and results: The three volunteer groups underwent a standard OGTT. Plasma samples obtained in the fasting state, 30 and 90 min after the OGTT, are subjected to a semitargeted GC-MS (gas chromatography-mass spectrometry) sugar profiling. Overall, 40 sugars are detected in plasma, of which some are yet unknown to change during an OGTT. Several sugars (e.g., trehalose) reveal significant differences between the volunteer groups both in fasting plasma and in distinct time courses after the OGTT. This suggests an endogenous production from orally absorbed glucose and/or an insulin-dependent production/removal from plasma. Conclusion: It is demonstrated that more sugars than expected can be found in human plasma. Since some of these show characteristic differences depending on health status, it may be worthwhile to assess their usability as biomarkers for diagnosing early-stage insulin resistance and type 2 diabetes.

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Sustained high plasma mannose less sensitive to fluctuating blood glucose in glycogen storage disease type Ia children

Nagasaka

Yorifuji

Bandsma

et al. 2012

J of Inher Metab Disea

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Plasma mannose is suggested to be largely generated from liver glycogen-oriented glucose-6-phosphate. This study examined plasma mannose in glycogen storage disease type Ia (GSD Ia) lacking conversion of glucose-6-phosphate to glucose in the liver. We initially examined fasting--and postprandial 2 h--plasma mannose and other blood carbohydrates and lipids for seven GSD Ia children receiving dietary interventions using cornstarch and six healthy age-matched children. Next, one-day successive intra-individual parameter changes were examined for six affected and two control children. Although there were no significant differences in fasting--and postprandial 2 h--glucose and insulin levels, the mannose level of the affected group was invariably much higher than that of the control group (p < 0.001): the fasting level of the affected group was about two-fold that of the control group; the postprandial-2 h level remained almost unchanged in the affected group, although it was one-half of the fasting level in the control group. Inter-individual analyses revealed that the GSD Ia group mannose level was significantly and positively correlated with lactate and triglycerides levels at both time points (p < 0.01). In each control, mannose levels fluctuated greatly, maintaining strong and significant negative correlations with glucose and insulin levels (p < 0.001). Correlations were lower or nonexistent in GSD Ia children. In individuals with high lactate and triglycerides levels, strikingly high mannose levels never changed against glucose and insulin fluctuations. Plasma mannose is less sensitive to blood glucose and insulin in GSD Ia children. Its basal level and the fluctuation pattern differ by their metabolic activity.

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Physiological changes in circulating mannose levels in normal, glucose-intolerant, and diabetic subjects

Cited by 46 publications

References 25 publications

Clinical significance of plasma mannose concentrations in healthy and diabetic dogs

Clinical significance of plasma mannose concentrations in healthy and diabetic dogs

Exploring the Diversity of Sugar Compounds in Healthy, Prediabetic, and Diabetic Volunteers

Sustained high plasma mannose less sensitive to fluctuating blood glucose in glycogen storage disease type Ia children

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