“…Phlorotannins have also been shown to regulate the biosynthesis ( Jung et al, 2010 ; Kang et al, 2013 ; Choi et al, 2015 ) and oligomerization ( Kang et al, 2011 ; Seong et al, 2019 ) of Aβ, as well as the neuroinflammatory ( Lee et al, 2018 ; Yang et al, 2021 ) and neurotoxic ( Kang et al, 2011 ; Ahn et al, 2012 ; Yang et al, 2015 ) pathways related to Aβ ( Figure 3 ). In animal experiments, phlorotannins exerted neuroprotective effects against the development and progression of AD ( Yang et al, 2015 , 2018 ), PD ( Ryu et al, 2013 ; Figure 4 ), and other CNS disorders ( Cho et al, 2012 ; Kim et al, 2012 ), and yielded measurable improvements in behavioral aspects such as learning ( Lee and Stein, 2004 ), memory ( Myung et al, 2005 ), movement ( Li et al, 2021 ), sleep ( Cho et al, 2012 , 2014 ; Yoon et al, 2014 ; Yoon et al, 2020 ), and symptomatic pain ( Li et al, 2021 ; Table 1 ). The anti-inflammatory ( Table 2 ) and antioxidative effects ( Table 3 ) of phlorotannins may provide generally neuroprotective effects in the brain.…”