Physicochemical properties of potential porphyrin photosensitizers for photodynamic therapy

Kempa, Marta; Kozub, Patrycja; Kimball, Joseph; Rojkiewicz, Marcin; Kuś, Piotr; Gryczynski, Z.; Ratuszna, A.

doi:10.1016/j.saa.2015.03.076

Cited by 42 publications

(19 citation statements)

References 44 publications

(49 reference statements)

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“…Porphyrin derivatives of this class also proved photodynamic activity similar to that of Foscan and chemical stability during irradiation in different solvents, including DMSO [17,18]. These physicochemical properties make them suitable for use as PS in photodynamic therapy [18].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficiency of photodynamic therapy on WM35 melanoma with synthetic porphyrins: Role of chemical structure, intracellular targeting and antioxidant defense

Bâldea¹,

Olteanu²,

Bolfă

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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Section: Discussionmentioning

confidence: 99%

“…The tested compounds, THOPP and THOMPP are derivatives of tetraphenyl porphyrins, a class of substances with good photodynamic activity and chemical stability [17,18] (Rojkiewicz, 2013, Kempa, 2015.…”

Section: Analytical Characterization Of the Photosensitizersmentioning

confidence: 99%

Efficiency of photodynamic therapy on WM35 melanoma with synthetic porphyrins: Role of chemical structure, intracellular targeting and antioxidant defense

Bâldea¹,

Olteanu²,

Bolfă

et al. 2015

Journal of Photochemistry and Photobiology B: Biology

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“…These graphenebase catalysts demonstrated encouraging photocatalytic activity and stability, indicating that graphene has great One-pot synthesis of manganese porphyrin covalently functionalized graphene oxide for enhanced photocatalytic hydrogen evolution Xia potential to be a useful construction component to build photocatalysts for hydrogen production [23]. Porphyrins and their metallic derivatives have been widely studied and have been proved as very promising photosensitizers for photocatalytic hydrogen production [24][25][26][27] owing to their large extinction coefficients in the visible-light region, prospective photochemical electron-transfer ability, excellent chemical and thermal stability and low cost [28,29]. In addition, the central metal of the metalloporphyrins can result in stronger and broader photoresponse in the visible region [30,31].…”

Section: Introductionmentioning

confidence: 99%

One-pot synthesis of manganese porphyrin covalently functionalized graphene oxide for enhanced photocatalytic hydrogen evolution

Wang

et al. 2017

J. Porphyrins Phthalocyanines

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ABSTRACT:In this paper, graphene oxide (GO) sheets covalently functionalized with (5,10,15,20-tetraphenyl) porphinato manganese(III) (MnTPP) has been successfully synthesized and tested as a photocatalyst for hydrogen evolution from water under UV-vis light irradiation. The obtained sample was systematically characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), UV-vis, Fourier transform infrared (FTIR), and Raman spectroscopy. The results show that the MnTPP moiety has been successfully grafted on the graphene oxide surface to form MnTPP modified GO (GO-MnTPP). The fluorescence quenching and photocurrent enhancement of GOMnTPP confirm that the rapid electrons transfer from photoexcited the MnTPP moiety to the GO sheets. The platinized GO-MnTPP exhibits enhanced photocatalytic activity for water reduction to produce hydrogen. Moreover, with the assistance of polyvinyl pyrrolidone (PVP), the photocatalytic activity is further improved because of aggregation prevention of the GO-MnTPP nanocomposite. This study provides a facile method to build porphyrin-graphene-based photocatalysts for solar energy conversion.

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“…Such as the porphyrinbased photosensitizer, Photofrin is administered systemically for the clinical treatment of esophageal and bronchial carcinomas as well as for treating Barrett's esophagus. Porphyrins are naturally occurring organic compounds which are involved in a variety of important biological processes [12].…”

Section: Introductionmentioning

confidence: 99%

Antitumor effects evaluation of a novel porphyrin derivative in photodynamic therapy

Magetic

et al. 2015

Tumor Biol.

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In this paper, the antitumor activity of a novel porphyrin-based photosensitizer 5,10,15,20-tetrakis[(5-diethylamino)pentyl] porphyrin (TDPP) was reported in vitro and in vivo. The photophysical and cellular properties of TDPP were investigated. The singlet oxygen generation quantum yield of TDPP was detected; it showed a high singlet oxygen quantum yield of 0.52. The intracellular distribution of photosensitizer was detected with laser scanning confocal microscopy. The efficiency of TDPP-photodynamic therapy (PDT) in vitro was analyzed by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay and in situ trypan blue exclusion test. Treated with a 630-nm laser, TDPP can kill cultured human esophageal cancer cell line (Eca-109) cells and reduce the growth of Eca-109 xenograft tumors significantly in BABL/c nude mice. And histopathological study was also used to confirm the antitumor effect. It has the perspective to be developed as a new antitumor drug in photodynamic therapy and deserves further investigation.

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Physicochemical properties of potential porphyrin photosensitizers for photodynamic therapy

Cited by 42 publications

References 44 publications

Efficiency of photodynamic therapy on WM35 melanoma with synthetic porphyrins: Role of chemical structure, intracellular targeting and antioxidant defense

Efficiency of photodynamic therapy on WM35 melanoma with synthetic porphyrins: Role of chemical structure, intracellular targeting and antioxidant defense

One-pot synthesis of manganese porphyrin covalently functionalized graphene oxide for enhanced photocatalytic hydrogen evolution

Antitumor effects evaluation of a novel porphyrin derivative in photodynamic therapy

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