Physicochemical characterization of cardiovascular calcified deposits

Tomažić, B.; Brown, W. E.; Queral, Luis A.; Sadovnik, M.

doi:10.1016/0021-9150(88)90284-5

Cited by 31 publications

(26 citation statements)

References 23 publications

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“…They found 65-85 wt% of inorganic matrix (weight loss up to 600°C) and on average 11.6 wt% of ''CaCO 3 '' in the calcified deposits [16]. This corresponds to our results.…”

Section: Resultssupporting

confidence: 91%

“…The similarity to human bone samples is also high [23]. Comparable results were also obtained by Li et al [24] and Tomazic et al [16] (see Fig. 5).…”

Section: Resultssupporting

confidence: 88%

“…We can therefore conclude that the mineral phase of the plaques consists of carbonated apatite only, and that no other solid phases are present. This is in good agreement with the results by Tomazic et al [4,16,22]. However, Bigi et al [28] found hydroxyapatite and also some highly crystalline b-tricalcium phosphate (b-TCP; b-Ca 3 (PO 4 ) 2 ) with magnesium content.…”

Section: Resultssupporting

confidence: 86%

“…Apparently, the calcification occurs by various mechanisms that do not lead to a distinct morphology. This was also noted by Tomazic et al [16] and by Lee et al [17].…”

Section: Resultssupporting

confidence: 78%

“…Tomazic et al [4,16,22] reported physicochemical measurements on calcified deposists. They found 65-85 wt% of inorganic matrix (weight loss up to 600°C) and on average 11.6 wt% of ''CaCO 3 '' in the calcified deposits [16].…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

A comparative study of clinically well-characterized human atherosclerotic plaques with histological, chemical, and ultrastructural methods

Becker

Epple

Müller

et al. 2004

Journal of Inorganic Biochemistry

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“…They found 65-85 wt% of inorganic matrix (weight loss up to 600°C) and on average 11.6 wt% of ''CaCO 3 '' in the calcified deposits [16]. This corresponds to our results.…”

Section: Resultssupporting

confidence: 91%

“…The similarity to human bone samples is also high [23]. Comparable results were also obtained by Li et al [24] and Tomazic et al [16] (see Fig. 5).…”

Section: Resultssupporting

confidence: 88%

Section: Resultssupporting

confidence: 86%

“…Apparently, the calcification occurs by various mechanisms that do not lead to a distinct morphology. This was also noted by Tomazic et al [16] and by Lee et al [17].…”

Section: Resultssupporting

confidence: 78%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

A comparative study of clinically well-characterized human atherosclerotic plaques with histological, chemical, and ultrastructural methods

Becker

Epple

Müller

et al. 2004

Journal of Inorganic Biochemistry

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Model experimental system for investigation of heart valve calcificationin vitro

Kapolos

Mavrilas

Missirlis

et al. 1997

J. Biomed. Mater. Res.

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A model system was developed for the in vitro quantitative investigation of the calcification process occurring in heart valves. The process of heart valve calcification consists of the formation of calcium phosphates at the heart valve-biological fluid interface. Calcium phosphate deposits may consist of more than one calcium phosphate mineral phase, differing with respect to their physical and chemical properties. The kinetics of the formation of hydroxyapatite, the model inorganic compound for the calcified deposits, was precisely monitored in a reactor containing supersaturated calcium phosphate solutions in which the heart valves were immersed after being treated with glutaraldehyde and mounted on special racks. The precipitation process, accompanied with proton release in the solution, was monitored by a pair of glass-saturated calomel electrodes. Upon initiation of the formation of calcium phosphate deposits, the supersaturation in the working solution was reestablished through the addition of titrant solutions made with the appropriate concentration to compensate for the ions precipitated. With this methodology, not only the rates were measured very precisely but also the nucleation capability of the various substrates could be evaluated. Moreover, it was possible to identify the formation of intermediate calcium phosphate phases formed during the calcification process. Valves previously treated with glutaraldehyde were shown to nucleate octacalcium phosphate, which at lower supersaturations converted to the thermodynamically more stable hydroxyapatite. The rates measured were found to depend on the solution supersaturation, while the apparent order of the precipitation process was found to be 1.

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A pilot study of subclinical coronary atherosclerosis in systemic sclerosis: Coronary artery calcification in cases and controls

Khurma

Meyer

Park³

et al. 2008

Arthritis & Rheumatism

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Objective. Systemic sclerosis (SSc) is associated with vasculopathy and endothelial cell injury, which could potentially increase the risk of coronary atherosclerosis. Multidetector computed tomography, a noninvasive procedure, generates a coronary calcium score (CCS) as a marker for coronary atherosclerosis. Serum proinflammatory high-density lipoprotein (piHDL) is a potential novel marker of atherosclerotic risk. The objective of the pilot study was to determine 1) the prevalence of subclinical coronary atherosclerosis in SSc and 2) serum piHDL levels as a potential novel marker of atherosclerotic risk in SSc. Methods. A cross-sectional study of 17 patients with SSc and 17 age-, sex-, and race-matched healthy controls in Cincinnati, Ohio, was conducted. Measurements included CCS; body mass index; lipid profile; and serum levels of high-sensitivity C-reactive protein, homocysteine, and piHDL. Results. Patients with SSc were slightly older (mean 52.8 years) than control subjects (mean 50.6 years; P ‫؍‬ 0.01). Coronary calcium was found in 12 participants (9 with SSc, 3 controls; P ‫؍‬ 0.03). The mean ؎ SD CCS in patients with SSc was significantly greater than the controls (126.6 ؎ 251.0 versus 14.7 ؎ 52.2; P ‫؍‬ 0.003). Five patients with SSc (29%), but no controls, had detectable levels of piHDL (P ‫؍‬ 0.06). Conclusion. Prevalence of subclinical coronary atherosclerosis is greater in patients with SSc compared with healthy controls. These findings should be confirmed in a larger study.

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Physicochemical characterization of cardiovascular calcified deposits

Cited by 31 publications

References 23 publications

A comparative study of clinically well-characterized human atherosclerotic plaques with histological, chemical, and ultrastructural methods

A comparative study of clinically well-characterized human atherosclerotic plaques with histological, chemical, and ultrastructural methods

Model experimental system for investigation of heart valve calcificationin vitro

A pilot study of subclinical coronary atherosclerosis in systemic sclerosis: Coronary artery calcification in cases and controls

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