volume 274, issue 1-2, P139-148 2004
DOI: 10.1016/j.ijpharm.2004.01.015
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Abstract: Local anaesthetics may be added to intravenous o/w emulsions of propofol to reduce the initial pain of injection. Due to incompatibility problems of the emulsion on the addition of a local anaesthetic solution, prior encapsulation of the drug within liposomes is suggested. The liposomes were prepared with the sonication method and loaded with either lidocaine hydrochloride (LiHCl) or prilocaine hydrochloride (PrHCl). The liposomal systems were characterised with photon correlation spectroscopy (PCS) in terms o…

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