Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: A step forward

Oliveira, Anderson M. de; Jäger, Eliézer; Jäger, Alessandro; Štěpánek, Petr; Giacomelli, Fernando C.

doi:10.1016/j.colsurfa.2013.08.056

Cited by 60 publications

(54 citation statements)

References 49 publications

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“…The PDI values of different batches were found to be in the range of 0.167±0.02 to 0.816±0.03. The small value of PDI (<0.20) indicates a homogeneous C-LPNCs, whereas a larger PDI (>0.3) value indicates heterogeneity (Oliveira et al, 2013). Further, CLPNCs exhibited negative zeta potential values in the range of -20.4±0.91 to -28.5±0.67 mV, which is attributed to the hydroxyl groups of maltodextrin of SMD that are deprotonated in their ionized form near neutral pH values (Christopher et al, 1999).…”

Section: Characterization Studiesmentioning

confidence: 92%

Lipopolysaccharide based oral nanocarriers for the improvement of bioavailability and anticancer efficacy of curcumin

Chaurasia

Patel

Chaubey

et al. 2015

Carbohydrate Polymers

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Section: Characterization Studiesmentioning

confidence: 92%

Lipopolysaccharide based oral nanocarriers for the improvement of bioavailability and anticancer efficacy of curcumin

Chaurasia

Patel

Chaubey

et al. 2015

Carbohydrate Polymers

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“…Opalescence is a characteristic pheno menon for colloidal suspensions exhibiting sizes in the range ≈ 50-90 nm while the milky white appearance refers to sizes larger than 100 nm. [ 19 ] Interestingly, addition of water into acetone solution afforded NPs (Figure 2 , sample F) with hydrodynamic diameter D H = 600 ± 3.4 nm and rather large particle dispersity Ð P = 0.23 ± 0.002. The size of NPs is nearly fi ve times greater compared to NPs prepared by classical nanoprecipitation ( D H = 117.3 ± 1.3 nm, Ð P = 0.02 ± 0.003; see Figure 2 , sample D) clearly illuminating the effect of the preparation protocol.…”

Section: Preparation Of Polyester Npsmentioning

confidence: 99%

“…Various physicochemical aspects governing the formation of colloidal NPs produced by the nanoprecipitation method such as the effect of organic solvent, polymer properties, polymer concentration, temperature effect, and antisolvent ionic strength were previously studied. [ 19 ] Systematic investigation revealed dependence of the fi nal NP size on the organic solvent and polymer concentration. Indeed, our experimental data collected for NPs prepared from acetone and THF are consistent with previous studies.…”

Section: Preparation Of Polyester Npsmentioning

confidence: 99%

“…The effect of intramolecular association between PBSE chains is favored in THF which has relatively low dielectric constant ε = 7.52 compared to acetone ε = 21.01. [ 19 ] Incorporation of a hydrophobic PBDL segment into PBSE changes the properties of copolyesters dramatically. The entire copolyester PBSE/PBDL series becomes readily soluble in acetone.…”

Section: Preparation Of Polyester Npsmentioning

confidence: 99%

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Multifunctional Amphiphilic Nanoparticles Featuring (Bio)Degradable Core and Dual‐Responsive Shell as Biomedical Platforms for Controlled Release

Gromadzki

Rychter

Uchman

et al. 2015

Macro Chemistry & Physics

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Multifunctional polymeric platforms combining (bio)degradable and biocompatible, temperature and pH-sensitive entities hold great promise as nanocarriers for targeted drug and gene delivery, and tissue engineering. In this work, preparation and characterization of surfactantfree polyester nanoparticles (NPs) from biobased polyesters poly(butylene sebacate) (PBSE) and poly(butylene sebacate-co -butylene dilinoleate)s (PBSE/PBDL) using nanoprecipitation is reported. This strategy leads to spherical nanosized particles with sizes narrowly distributed in a range of 30-200 nm which is appropriate for internalization by a variety of cells. The effect of molecular parameters and type of solvent used in the nanoprecipitation protocol on the size and shape of produced polyester nanocolloids and their in vitro degradation in PBS solution at 37 °C is elucidated by quasi-elastic light scattering (QELS), atomic force microscopy (AFM), transmission electron microscopy (TEM), and sizeexclusion chromatography (SEC) techniques. A dense cationic brush layer (≈ 20 nm) of stimuli-responsive and biocompatible poly(2-dimethylaminoethyl methacrylate-co -acrylonitrile) is grafted on the surface of PBSE/PBDL NPs through "grafting onto" (arm fi rst) coupling chemistry.

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“…Polydispersity index is an index ranging from zero, when all microparticles of the dispersion presenting relatively the same size, and 1.0, when the average particle diameter is heterogeneous (Oliveira et al, 2013). Microparticles composed by HPMC and CS presented index of 1.0 or near of it, indicating low homogeneity of the particle size.…”

Section: Physicochemical Characterization Of Floating Microparticlesmentioning

confidence: 99%

Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying

Nohemann

Almeida

Ferrari

2017

Braz. J. Pharm. Sci.

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Gastroretentive floating microparticles were developed and evaluated for the controlled metronidazole delivery for treatment of gastric disease. Floating microparticles, varying in proportions of chitosan and hydroxypropyl methylcellulose or ethylcellulose, were obtained by spray drying. Floating microparticles were characterized by physicochemical and in vitro studies, according to their floating ability and drug delivery. Microparticles presented mean diameter from 1.05 to 2.20 µm. The infrared spectroscopy confirmed the drug encapsulation and showed no chemical linkage between microparticles components. X-ray diffraction showed changes in the drug`s solid state, from crystalline to amorphous, indicating partial drug encapsulation, due to the presence of some crystalline peaks of metronidazole in microparticles. All microparticles floated immediately in contact of simulated gastric fluid and both floating and drug release profiles were dependent of microparticles composition. Microparticles samples constituted by chitosan and hydroxypropyl methylcellulose revealed the best relationship between floating duration and drug release, remaining floating during the occurrence of the drug release, ideal condition for the floating gastroretentive systems.Uniterms: Floating microparticle. Chitosan. Ethylcellulose. Hydroxypropyl methylcellulose. Controlled drug delivery.

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Physicochemical aspects behind the size of biodegradable polymeric nanoparticles: A step forward

Cited by 60 publications

References 49 publications

Lipopolysaccharide based oral nanocarriers for the improvement of bioavailability and anticancer efficacy of curcumin

Lipopolysaccharide based oral nanocarriers for the improvement of bioavailability and anticancer efficacy of curcumin

Multifunctional Amphiphilic Nanoparticles Featuring (Bio)Degradable Core and Dual‐Responsive Shell as Biomedical Platforms for Controlled Release

Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying

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