Physicochemical and toxicological evaluation of silica nanoparticles suitable for food and consumer products collected by following the EC recommendation

Contado, Catia; Mejia, Jorge; García, Omar Lozano; Piret, Jean-Pascal; Dumortier, Elise; Toussaint, Olivier; Lucas, Stéphane

doi:10.1007/s00216-015-9101-8

Cited by 36 publications

(27 citation statements)

References 41 publications

(24 reference statements)

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“…In vitro, neither pyrogenic nor precipitated silica affected the cell barrier integrity in Caco-2 intestinal cells, even after long-term exposure (7–21 days); with both pyrogenic and precipitated silica cytotoxic and cytostatic effects were registered only at very high concentrations (≥100 mg/L in human gastric epithelial cells (GES-1) and Caco-2 cells) (Contado et al 2016; Farcal et al 2015; Yang et al 2014). In liver cells, GSH depletion and oxidative stress have been found only at very high test concentrations (≥200 mg/L), or long incubation times (25 mg/L for 72 h); aspartate aminotransferase in buffalo rat liver cells incubated with supernatant from SiO 2 -stimulated Kupffer cells (resident hepatic macrophages) was only increased at ≥400 mg SiO 2 /L (Chen et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Currently, there are no reliable standardised analytical methods available to characterise the number weighted particle size distribution of SAS in the nanosize range below 100 nm. Efforts to establish such distributions suffer from the assumption of a spherical particle shape, see, for example, (Barahona et al 2016; Contado et al 2016), which is not correct in the case of E 551 as the E 551 aggregate is not a sphere.…”

Section: E 551 Particle Morphology and Sizementioning

confidence: 99%

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The safety of nanostructured synthetic amorphous silica (SAS) as a food additive (E 551)

Fruijtier-Pölloth¹

2016

Arch Toxicol

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Key messages Particle sizes of E 551 products are in the micrometre range. The typical external diameters of the constituent particles (aggregates) are greater than 100 nm. E 551 does not break down under acidic conditions such as in the stomach, but may release dissolved silica in environments with higher pH such as the intestinal tract. E 551 is one of the toxicologically most intensively studied substances and has not shown any relevant systemic or local toxicity after oral exposure. AbstractSynthetic amorphous silica (SAS) meeting the specifications for use as a food additive (E 551) is and has always been produced by the same two production methods: the thermal and the wet processes, resulting in E 551 products consisting of particles typically in the micrometre size range. The constituent particles (aggregates) are typically larger than 100 nm and do not contain discernible primary particles. Particle sizes above 100 nm are necessary for E 551 to fulfil its technical function as spacer between food particles, thus avoiding the caking of food particles. Based on an in-depth review of the available toxicological information and intake data, it is concluded that the SAS products specified for use as food additive E 551 do not cause adverse effects in oral repeated-dose studies including doses that exceed current OECD guideline recommendations. In particular, there is no evidence for liver toxicity after oral intake. No adverse effects have been found in oral fertility and developmental toxicity studies, nor are there any indications from in vivo studies for an immunotoxic or neurotoxic effect. SAS is neither mutagenic nor genotoxic in vivo. In intact cells, a direct interaction of unlabelled and unmodified SAS with DNA was never found. Differences in the magnitude of biological responses between pyrogenic and precipitated silica described in some in vitro studies with murine macrophages at exaggerated exposure levels seem to be related to interactions with cell culture proteins and cell membranes. The in vivo studies do not indicate that there is a toxicologically relevant difference between SAS products after oral exposure. It is noted that any silicon dioxide product not meeting established specifications, and/or produced to provide new functionality in food, requires its own specific safety and risk assessment.

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Section: Discussionmentioning

confidence: 99%

Section: E 551 Particle Morphology and Sizementioning

confidence: 99%

The safety of nanostructured synthetic amorphous silica (SAS) as a food additive (E 551)

Fruijtier-Pölloth¹

2016

Arch Toxicol

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“…Therefore, by determining the eff ective combined constant (K) using the standard size particles, equation ⑵ can be reduced to equation ⑶ and shown as a function of only time. The DCS method enables the quantitative analysis of minute particles with broad size distributions from 5 nm to 10 μm, and has been used to evaluate various nanomaterials such as pol ymer latex, silica particles, and carbon nanotubes [14][15][16] . Fig.…”

Section: Evaluation Of Cnfs By Centrifugal Sedimentation Methodsmentioning

confidence: 99%

Evaluation of Cellulose Nanofi bers by Using Sedimentation Method

Kumagai

Endo

Adachi³

2019

J. Tappi J.

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“………⑶ DCS 法では，遠心により分級を行いながら微小粒子の粒子径を評価・解析することができるため，広い領域の粒子径(5 nm ～ 10 μm)の微細粒子を高分解能で定量的に分析することが可能であり，ポリマーラテックスやシリカ粒子，カーボンナノチューブなど様々なナノ材料の評価に利用されている [14][15][16] (Fig. 7a) ，十分に解繊が進行した CNF 分散液のプロファイルにサブミクロンサイズの新しいピークが出現するなど (Fig.…”

unclassified

沈降法によるセルロースナノファイバーの評価

2019

J. Tappi J.

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The practicality of sedimentation method for evaluating the diameter and morphology of cellulose nanofibers(CNFs)in CNF dispersions was studied using CNFs with diff erent degrees of fi brillation prepared by the mechanical fi brillation of softwood bleached kraft pulp. Evaluations of the CNF dispersions were performed using a stability analyzer and centrifuge particle size analyzer based on the gravitational sedimentation method and diff erential centrifugal sedimentation(DCS)method, respectively. The sedimentation behavior of CNFs provided by the stability analyzer refl ected the fi ber morphologies, and good correlation was found between the Stokes' diameter obtained by the DCS method and the fi ber diameters estimated from fi eld-emission scanning electron microscopy observations. These results show the possibility of using analysis based on the sedimentation method for evaluating the diameter and morphology of cellulose fi bers in CNF dispersions, including the cellulose fi bers obtained by fi brillation. Keywords： cellulose nanofi ber, sedimentation method, dispersion stability, diff erential centrifugal sedimentation method 分類：Q 0 その他，L 0 その他，Y 0 その他

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Physicochemical and toxicological evaluation of silica nanoparticles suitable for food and consumer products collected by following the EC recommendation

Cited by 36 publications

References 41 publications

The safety of nanostructured synthetic amorphous silica (SAS) as a food additive (E 551)

The safety of nanostructured synthetic amorphous silica (SAS) as a food additive (E 551)

Evaluation of Cellulose Nanofi bers by Using Sedimentation Method

沈降法によるセルロースナノファイバーの評価

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