Physicochemical and conformational studies on interaction of myoglobin with an amino-acid based anionic surfactant, sodium N-dodecanoyl sarcosinate (SDDS)

Mondal, Satyajit; Raposo, Maria Luz; Ghosh, Asitanga; Prieto, Gerardo; Ghosh, Soumen

doi:10.1016/j.colsurfa.2019.05.061

Cited by 17 publications

(3 citation statements)

References 36 publications

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“…In our experimental results, the decreased intrinsic fluorescence with the addition of 2,4-Dec suggested that fewer tyrosine and tryptophan were exposed in the Mb induced by 2,4-Dec, verifying that the digestibility and digested peptide of Mb were restrained by 2,4-Dec under thermal treatment. Nevertheless, the fluorescence intensity of DMRC was significantly increased following treatment with increasing temperatures in our studies because under thermal processing, the spatial configuration of the protein is more stretched or tryptophan residues extend away from heme and become unconcealed in a polar environment . The intrinsic fluorescence intensity had a significant positive correlation with digestibility (Table S2), which also indicated that the polymerization and modification of proteins restrained digestibility and decreased quantity of peptide.…”

Section: Discussionmentioning

confidence: 61%

“…Nevertheless, the fluorescence intensity of DMRC was significantly increased following treatment with increasing temperatures in our studies because under thermal processing, the spatial configuration of the protein is more stretched or tryptophan residues extend away from heme and become unconcealed in a polar environment. 50 The intrinsic fluorescence intensity had a significant positive correlation with digestibility (Table S2), which also indicated that the polymerization and modification of proteins restrained digestibility and decreased quantity of peptide.…”

Section: ■ Discussionmentioning

confidence: 88%

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Molecular Mechanisms Underlying the Effect of Lipid Oxidation Products on Digestibility and Conformation of Myoglobin under Thermal Treatment

Zhuang,

Wang,

Dong

et al. 2023

J. Agric. Food Chem.

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Lipid oxidation can produce lipid oxidation products (LOPs), which further react with proteins and affect their structure and digestibility, although the underlying mechanism remains unclear. Herein, we investigated the conformation and digestibility of proteins induced by LOPs after thermal treatment. Digestibility of myoglobin (Mb) affected by trans,trans,-2,4decadienal (2,4-Dec) was significantly reduced under high temperature (100−180 °C). The peptides digested from Mb modified with 2,4-Dec during thermal processing revealed that the quantity of peptides decreased with increasing 2,4-Dec concentrations. Proteomic analysis showed that 2,4-Dec covalently binds to Mb, and the extent of modification was in the following order: lysine > histidine > arginine. Moreover, the secondary structure, intrinsic fluorescence, and surface hydrophobicity results suggested that 2,4-Dec induced changes in Mb, leading to a tighter spatial structure and aggregation, and exposure of fewer recognition sites of the enzyme and thermal treatment assisted these changes in the structure. Meanwhile, molecular dynamics simulations elucidated the molecular mechanisms underlying the effect of 2,4-Dec and temperature on the digestion and structure of Mb.

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Section: Discussionmentioning

confidence: 61%

Section: ■ Discussionmentioning

confidence: 88%

Molecular Mechanisms Underlying the Effect of Lipid Oxidation Products on Digestibility and Conformation of Myoglobin under Thermal Treatment

Zhuang,

Wang,

Dong

et al. 2023

J. Agric. Food Chem.

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show abstract

“…For example, hydrophobized phenylalanine and valine derivatives demonstrated high cytotoxicity against the MCF-7 and HEK cell lines [ 26 ], pH-dependent self-assembly behavior [ 27 ] and could be used for construction of worm-like aggregates for ibuprofen delivery [ 28 ]. As a separate line of investigation, the interaction of these amphiphiles with biological species should be mentioned: glycine and sarcosinate derivatives are approved as effective agents for complexation with carrageenans of various types [ 29 ] and myoglobin [ 30 ]. Besides, compositions based on amphiphiles with amino acid fragments exhibit controlled morphological [ 31 ] and rheological [ 32 ] behavior, valuable in oil recovery processes, for antimicrobial activity and suitable biodegradability [ 33 ].…”

Section: Self-assembly Of Amphiphilic Compoundsmentioning

confidence: 99%

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Kashapov

Gaynanova

Gabdrakhmanov

et al. 2020

IJMS

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This review focuses on synthetic and natural amphiphilic systems prepared from straight-chain and macrocyclic compounds capable of self-assembly with the formation of nanoscale aggregates of different morphology and their application as drug carriers. Since numerous biological species (lipid membrane, bacterial cell wall, mucous membrane, corneal epithelium, biopolymers, e.g., proteins, nucleic acids) bear negatively charged fragments, much attention is paid to cationic carriers providing high affinity for encapsulated drugs to targeted cells. First part of the review is devoted to self-assembling and functional properties of surfactant systems, with special attention focusing on cationic amphiphiles, including those bearing natural or cleavable fragments. Further, lipid formulations, especially liposomes, are discussed in terms of their fabrication and application for intracellular drug delivery. This section highlights several features of these carriers, including noncovalent modification of lipid formulations by cationic surfactants, pH-responsive properties, endosomal escape, etc. Third part of the review deals with nanocarriers based on macrocyclic compounds, with such important characteristics as mucoadhesive properties emphasized. In this section, different combinations of cyclodextrin platform conjugated with polymers is considered as drug delivery systems with synergetic effect that improves solubility, targeting and biocompatibility of formulations.

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Impact of 2,2,2-trifluoroethanol (TFE) on hydrophobicity enhancement in the aggregation of sodium N-dodecanoyl sarcosinate (SDDS) with nonionic hydroxyethyl cellulose

Mondal,

Banik,

Ghosh

2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Physicochemical and conformational studies on interaction of myoglobin with an amino-acid based anionic surfactant, sodium N-dodecanoyl sarcosinate (SDDS)

Cited by 17 publications

References 36 publications

Molecular Mechanisms Underlying the Effect of Lipid Oxidation Products on Digestibility and Conformation of Myoglobin under Thermal Treatment

Molecular Mechanisms Underlying the Effect of Lipid Oxidation Products on Digestibility and Conformation of Myoglobin under Thermal Treatment

Self-Assembly of Amphiphilic Compounds as a Versatile Tool for Construction of Nanoscale Drug Carriers

Impact of 2,2,2-trifluoroethanol (TFE) on hydrophobicity enhancement in the aggregation of sodium N-dodecanoyl sarcosinate (SDDS) with nonionic hydroxyethyl cellulose

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