Physico-chemical and Rheological Properties of  Karaya Gum (Sterculia urens Roxb.)

Sahu, Pooja Devi; Pisalkar, P. S.; Patel, Saroj Kumar; Katiyar, Pratibha

doi:10.20546/ijcmas.2019.804.072

Cited by 7 publications

(1 citation statement)

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“…Natural gums have been reported with more than one pH value and this variability is mainly due to factors like topography, harvest season, stage of maturity, etc. For instance, Karaya gum (from Sterculia urens) variants with pH ranges from 6.7 to 7.3 have been reported [20] and consequently ranges in viscosity presented while another study found a pH of 4.26 [21]. increased to over twenty times that of tragacanth gum (6.57 mPas).…”

Section: Resultsmentioning

confidence: 99%

Potentials of Sterculia tragacantha Lindl seed husk gum as a release modifier in matrix tablet formulation

Timma Oto-Obong Uwah,

Ekaette Ibanga Akpabio,

Tenderwealth Clement Jackson

et al. 2023

GSC Biol. Pharm. Sci.

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Natural gums have been utilized severally in the design of matrix tablets, either in their native or modified forms. The primary objective of this work was the extraction, characterization and utilization of the seed husk gum from Sterculia tragacantha Lindl as a release modifier in theophylline matrix tablets. Gum was extracted from the fresh seed husk of Sterculia tragacantha and tablet formulated via wet granulation. Drug-polymer compatibility was determined by FTIR and DSC while formulated tablets were evaluated for their in vitro dissolution release profile in two media, simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) and compared with a commercial brand. Extracted gum powder presented a poor flow which improved on granulation, had a better swelling index and water holding capacity than tragacanth gum. Formulated tablets passed standard tablets test and sustained theophylline release up to 90.97 % and 88.09 % in SGF and SIF respectively at the twelfth hour. Drug release kinetics was by zero order in SGF via non-fickian diffusion. S. tragacantha seed husk gum presented a promising potential as a release retarding agent.

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Section: Resultsmentioning

confidence: 99%