Physical training improves skeletal muscle metabolism in patients with chronic heart failure

Adamopoulos, Stamatis; Coats, Andrew J.S.; Brunotte, F; Arnolda, Leonard F; Meyer, Theo E.; Thompson, Campbell; Dunn, Jeff F.; Stratton, John R.; Kemp, Graham J.; Radda, George K.; Rajagopalan, B.

doi:10.1016/0735-1097(93)90231-o

Cited by 338 publications

(186 citation statements)

References 31 publications

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“…[15][16][17] In our study the ventilatory response to exercise (VE/VCO 2 ; EqCO 2 ) was low while the patient was on the VAD and similar to that after heart transplantation. This variable is often increased in heart failure and is considered an important prognostic marker.…”

Section: Discussionsupporting

confidence: 60%

Left ventricular assist device: a functional comparison with heart transplantation

Pruijsten

Jonge²,

Kirkels³

et al. 2008

NHJL

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Background. A growing number of patients with end-stage heart failure undergo implantation of ventricular assist devices as a bridge to heart transplantation. Objectives. In this study we investigated whether functional and haemodynamic recovery after implantation is sufficient to warrant the use of them as long-term alternative to heart transplantation. Methods. We compared peak VO 2 of a group of patients three months after implantation of a ventricular assist device and three months after heart transplantation. Furthermore, we analysed the degree of haemodynamic recovery, by comparing plasma levels of BNP and creatinine before and after implantation of the device. Results. After implantation of a ventricular assist device, exercise capacity improved considerably; three months after implantation peak VO 2 was 20.0±4.9 ml/kg/min (52% of predicted for age and gender). After heart transplantation exercise capacity improved even further; 24.0±3.9 ml/ kg/min (62% of predicted for age and gender) (p<0.001). In the three months after implantation, BNP plasma levels decreased from 570±307 pmol/l to 31±25 pmol/l and creatinine levels decreased from 191±82 µmol/l to 82±25 µmol/l, indicating significant unloading of the ventricles and haemodynamic recovery. Conclusion. With regard to functional and haemodynamic recovery, the effect of implantation of a ventricular assist device is sufficient to justify its use as an alternative to heart transplantation. (Neth Heart J 2008;16:41-6.)

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Section: Discussionsupporting

confidence: 60%

Left ventricular assist device: a functional comparison with heart transplantation

Pruijsten

Jonge²,

Kirkels³

et al. 2008

NHJL

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“…Beneficial changes in structure, metabolism and biochemical function of skeletal muscle have been observed after training, culminating in an increase in oxidative capacity ( Adamopoulos et al 1993;Sullivan et al 1988), but none of these aspects were investigated in this study.…”

Section: ~~-------------------------------------mentioning

confidence: 99%

“…Further investigations by Adamopoulos et al (1993) of the patients involved in the study by Coats et al (1992) found that the oxidative capacity of skeletal muscle, as measured by ADP and phosphocreatine content, improved with eight weeks of training. Coats et al (1992) also found evidence that training enhanced vagal activity and decreased sympathetic activity, similar to that seen in healthy subjects.…”

Section: Exercise Training Programmesmentioning

confidence: 99%

Effects of Rehabilitation in Patients with Cardiac Disease

Taylor¹

1996

Physiotherapy

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“…These favourable changes result in an important reduction in dyspnoea and in a small decrease in fatigue, and therefore in an increase in the capacity to perform physical activity. 27 In the medium range, increased physical activity, particularly if it includes exercise training, would improve the structure and function of skeletal muscle [29][30][31][32][33] and would reduce excess ventilation, [33][34][35][36] thereby mitigating dyspnoea and fatigue further.…”

Section: Introductionmentioning

confidence: 99%

Diuretics in the treatment of patients who present congestive heart failure and hypertension

Reyes¹

2002

J Hum Hypertens

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The main operational objective of diuretic therapy in patients who present congestive heart failure and hypertension is to reduce or to suppress excess bodily fluid. Effective diuretic therapy decreases cardiac size when the heart is dilated, and it reduces lung congestion and excess water. Consequently, external respiratory work diminishes and cardiac output would be redistributed in favour of systemic vascular beds other than that of the respiratory muscles; dyspnoea decreases markedly and there is a slight reduction in fatigue. This clinical improvement and the fall in body weight caused by diuretics entail an increase in effort capacity. Subsequent exercise training ameliorates the abnormal ventilatory response to physical effort and the skeletal muscle myopathy that occur in heart failure, and thereby it attenuates dyspnoea and decreases fatigue further. Loop and/or thiazide-type diuretics may be used to aug-

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Physical training improves skeletal muscle metabolism in patients with chronic heart failure

Cited by 338 publications

References 31 publications

Left ventricular assist device: a functional comparison with heart transplantation

Left ventricular assist device: a functional comparison with heart transplantation

Effects of Rehabilitation in Patients with Cardiac Disease

Diuretics in the treatment of patients who present congestive heart failure and hypertension

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