Physical training effects in renal transplant recipients

Romano, Giulio; Simonella, R.; Falleti, Edmondo; Bortolotti, Nadia; Deiuri, E.; Antonutto, G.; Vita, Salvatore De; Ferraccioli, Gianfranco; Montanaro, Domenico

doi:10.1111/j.1399-0012.2009.01098.x

Cited by 29 publications

(24 citation statements)

References 35 publications

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“…18.1 [ 74 , 75 ]. A small study of prescribed exercise in renal transplant recipients demonstrated improved cardiorespiratory parameters, such as V O 2 max, but no difference in any of the measured biochemical parameters [ 76 ]. Of note in this study was a statistically signifi cant decrease in the infl ammatory cytokine IL-6 after 30 sessions of exercise training.…”

Section: Diet and Exercisementioning

confidence: 90%

The Prevention and Treatment of Coronary Artery Disease in Kidney Transplant Recipients

Adey

2014

Kidney Transplantation

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Section: Diet and Exercisementioning

confidence: 90%

The Prevention and Treatment of Coronary Artery Disease in Kidney Transplant Recipients

Adey

2014

Kidney Transplantation

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“…In a high-intensity interval training study (3-weekly sessions of 15× 1-minute intervals at 90% HR peak ) in renal transplant patients large reductions in IL-6 were reported after 10 weeks (before 2.8 ± 0.6 versus after 1.7 ± 0.5 pg/mL) [109]. Although this study had no control group this may represent a training load required to stimulate a significant adaptation.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Factors and Exercise in Chronic Kidney Disease

Dungey

Hull

Smith

et al. 2013

International Journal of Endocrinology

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Patients with chronic kidney disease frequently present with chronic elevations in markers of inflammation, a condition that appears to be exacerbated by disease progression and onset of haemodialysis. Systemic inflammation is interlinked with malnutrition and muscle protein wasting and is implicated in a number of morbidities including cardiovascular disease: the most common cause of mortality in this population. Research in the general population and other chronic disease cohorts suggests that an increase in habitual activity levels over a prolonged period may help redress basal increases in systemic inflammation. Furthermore, those populations with the highest baseline levels of systemic inflammation appear to have the greatest improvements from training. On the whole, the activity levels of the chronic kidney disease population reflect a sedentary lifestyle, indicating the potential for increasing physical activity and observing health benefits. This review explores the current literature investigating exercise and inflammatory factors in the chronic kidney disease population and then attempts to explain the contradictory findings and suggests where future research is required.

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“…Furthermore, it is likely that their reported maximal exercise values are considerably below their own potential maximum pre-RTx, as athletic populations typically demonstrate much higherVo 2peak than the average population, although this obviously cannot be tested in these RTx recipients (237). Studies in RTx patients with mean ages of 40 to 50 years also demonstrated a lowVo 2peak relative to controls or predicted values (11,248,265). Petersen et al found aVo 2peak of 27.0 ml.kg −1 .min −1 in nine RTx aged 41 years (254, 317), which was 76% of the matched control group.…”

Section: Nrmentioning

confidence: 93%

Exercise Limitation Following Transplantation

Williams

McKenna

2012

Comprehensive Physiology

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Organ transplantation is one of the medical miracles or the 20th century. It has the capacity to substantially improve exercise performance and quality of life in patients who are severely limited with chronic organ failure. We focus on the most commonly performed solid‐organ transplants and describe peak exercise performance following recovery from transplantation. Across all of the common transplants, evaluated significant reduction in o 2 peak is seen (typically renal and liver 65%‐80% with heart and/or lung 50%‐60% of predicted). Those with the lowest o 2 peak pretransplant have the lowest o 2 peak posttransplant. Overall very few patients have a o 2 peak in the normal range. Investigation of the cause of the reduction of o 2 peak has identified many factors pre‐ and posttransplant that may contribute. These include organ‐specific factors in the otherwise well‐functioning allograft (e.g., chronotropic incompetence in heart transplantation) as well as allograft dysfunction itself (e.g., chronic lung allograft dysfunction). However, looking across all transplants, a pattern emerges. A low muscle mass with qualitative change in large exercising skeletal muscle groups is seen pretransplant. Many factor posttransplant aggravate these changes or prevent them recovering, especially calcineurin antagonist drugs which are key immunosuppressing agents. This results in the reduction of o 2 peak despite restoration of near normal function of the initially failing organ system. As such organ transplantation has provided an experiment of nature that has focused our attention on an important confounder of chronic organ failure‐skeletal muscle dysfunction. © 2012 American Physiological Society. Compr Physiol 2:1937‐1979, 2012.

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Physical training effects in renal transplant recipients

Abstract: This study suggests that an appropriate dose of physical training is a useful, safe and non-pharmacologic contribution to RTR treatment.

Cited by 29 publications

References 35 publications

The Prevention and Treatment of Coronary Artery Disease in Kidney Transplant Recipients

The Prevention and Treatment of Coronary Artery Disease in Kidney Transplant Recipients

Inflammatory Factors and Exercise in Chronic Kidney Disease

Exercise Limitation Following Transplantation

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