Physical Gels Based on Charge-Driven Bridging of Nanoparticles by Triblock Copolymers

Lemmers, Marc; Spruijt, Evan; Akerboom, Sabine; Voets, Ilja K.; Aelst, A.C. van; Stuart, Martien A. Cohen; Gucht, Jasper van der

doi:10.1021/la301917e

Cited by 21 publications

(20 citation statements)

References 45 publications

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“…[8][9][10][11][12][13][14][15] These ionic complexation-driven assemblies are of longstanding interest because of their broad industrial applications including underwater adhesives, 16 encapsulants, 17,18 delivery, 19,20 and smart hydrogels. [21][22][23] Polyelectrolyte complex (PEC) micelles are a type of nanoscale self-assembly that possesses micellar cores of ionic complexes and coronas of neutral polymers. Polyelectrolyte complex micelles perform well in gene and protein delivery since positively-charged polymers can condense large nucleic acids into small nanostructures and neutralize the negatively-charged moieties on the nucleic acid chains, protecting them from potential enzymatic degradation and promoting successful transfection into various cell types.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Dissociation Kinetics in Polyelectrolyte Complex Micelles

Ting

Tirrell

2020

Macromolecules

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Polyelectrolyte-based nanoscale self-assemblies, such as micelles, possess diverse desirable attributes such as capability for sequestering and protecting biomacromolecules against inhospitable environments, responsiveness to external stimuli, and tunability of physical behavior. However, little is known on the mechanisms of dissociation when micelles encounter and respond to environmental changes. Using salt-jump, timedependent, light scattering, the pathway of dissociation is observed in polyelectrolyte complex micelles that have complex cores and neutral coronas. The micelle dissociation kinetics appear to be a three-staged process, in good agreement with the scattering data. Using kinetic models of amphiphilic block copolymer micelles in polyelectrolyte complexation-driven micelles, we derive an analytical expression for dissociation relaxation rates as a function of solvent temperature, salt concentration, and the length of the charged polymer blocks. The theoretical predictions are compatible with the experimental data from light scattering experiments. This study demonstrates experimentally the relaxation kinetics of polyelectrolyte complex micelle dissociation and 1 illustrates the underlying mechanism governing the dissociation kinetics. It is anticipated that these findings can be generalized to other electrostatic interaction-driven self-assemblies to better understand the relationship among the kinetics of dissociation, constituent polymer properties, and environmental parameters.

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Section: Introductionmentioning

confidence: 99%

Mechanism of Dissociation Kinetics in Polyelectrolyte Complex Micelles

Ting

Tirrell

2020

Macromolecules

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“…Indeed, the mixing protocol is critical and different preparation pathways can lead to different outcomes, while the strength of the interactions can also be used as a parameter to control final structures. NC gels based on physical interactions have been obtained with a wide variety of polymer architectures − block copolymers, polymers grafted with sticky groups, star polymers or single‐stranded DNA − and a range of NPs: laponite, silica, cellulose nanocrystals, graphene oxide sheets and metal oxide NPs . In some cases, the interactions, despite being non‐covalent, are so strong that the gelation process is virtually irreversible …”

Section: Mechanical Propertiesmentioning

confidence: 99%

Soft nanocomposites: nanoparticles to tune gel properties

Silva

Dreiss

2015

Polymer International

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The demand for new, soft materials with bespoke physical and biological characteristics and functionality has fuelled the research into nanocomposite hydrogels. 'Soft' nanocomposites -nanoparticles within a hydrated, polymeric gel matrix -offer a simple, yet versatile, platform for the design of materials with specific -and tunable -properties. Indeed, the 'soft' properties of the matrix can be combined with the inherent functionality of the nanoparticles (drug loading, antimicrobial, light refraction etc.) or give rise to altogether new characteristics (toughness, optical properties, self-healing etc.) evolved from the synergistic interaction of the polymer chains with the particles. In this review, we report the evolution and achievements of nanocomposite gels, with a focus on mechanisms and structure. The review is therefore structured around the properties resulting from the gel/nanoparticle association, rather than a classification based on applications or specific types of polymer or nanoparticles. How can nanoparticles tune mechanical, optical, biological properties or impart stimuli-responsiveness to a polymer gel matrix − and how is this behaviour linked to the underlying structure?

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“…Hydrogels belong to a class of soft matter, which has attracted a lot of attention in recent years. Particularly stimuli-responsive and physically crosslinked gels have many potential applications in biomedicine and have been the subject of intensive research [98][99][100][101][102][103]. Due to its temperature and pH-sensitive behavior, PDMAEMA can be used in a variety of ways to produce reversible hydrogels [104,105].…”

Section: Hydrogel Formation Featuring Pdmaemamentioning

confidence: 99%

Star-shaped poly[2-(dimethylamino)ethyl methacrylate] and its derivatives: toward new properties and applications

et al. 2014

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The versatility of polymer and hybrid systems containing the polycation PDMAEMA, especially in the star-shaped topology, is reviewed. Different complexation schemes are addressed, including the use of stimuli-responsive counterions. This leads to the use of PDMAEMA stars for nucleotide transfection or advanced hydrogel formulations. GwieŸdzisty poli(metakrylan 2-dimetyloaminoetylu) i jego pochodne -nowe w³aoeciwooeci i kierunki zastosowañStreszczenie: Artyku³ stanowi przegl¹d literaturowy dotycz¹cy w³aoeciwooeci i zastosowania poli(metakrylanu 2-dimetyloaminoetylu) (PDMAEMA) i jego pochodnych. Przedstawiono wszechstronnooeae bazowego polimeru oraz uk³adów hybrydowych zawieraj¹cych polikation PDMAEMA, zw³aszcza o gwieŸdzistej topologii. Omówiono mo¿liwooeci wykorzystania wra¿liwooeci polimeru na zmiany temperatury i pH roztworu, a tak¿e ró¿ne schematy kompleksowania z udzia³em przeciwjonów reaguj¹cych na wspomniane bodŸce. GwieŸdziste pochodne PDMAEMA mog¹ znaleŸae zastosowanie w terapii genowej do transfekcji nukleotydów, jak równie¿ do wytwarzania zaawansowanych preparatów hydro¿elowych.S³owa kluczowe: polimer reaguj¹cy na bodŸce, polimer gwieŸdzisty, micelizacja, transfekcja genów, hydro¿el, hybrydy. 66 2014, , 59 nr 1

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Physical Gels Based on Charge-Driven Bridging of Nanoparticles by Triblock Copolymers

Cited by 21 publications

References 45 publications

Mechanism of Dissociation Kinetics in Polyelectrolyte Complex Micelles

Mechanism of Dissociation Kinetics in Polyelectrolyte Complex Micelles

Soft nanocomposites: nanoparticles to tune gel properties

Star-shaped poly[2-(dimethylamino)ethyl methacrylate] and its derivatives: toward new properties and applications

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