Physical fitness throughout chemotherapy in children with acute lymphoblastic leukaemia and lymphoma

Vriens, Annelies; Verschueren, Sabine; Vanrusselt, Deveny; Troosters, Thierry; Gielis, Marjoke; Dirix, Veerle; Vanderhenst, Ellen; Sleurs, Charlotte; Uyttebroeck, Anne

doi:10.1007/s00431-022-04741-z

Cited by 3 publications

(12 citation statements)

References 46 publications

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“…Thirteen studies 22,[34][35][36][37][38][39][40][41][42][43][44][45] with 14 patient groups were compared to healthy controls, including 594 children diagnosed with cancer, and 3674 unique healthy controls were included. Figure 1 shows a PRISMA flow diagram illustrating the study identification and selection process.…”

Section: Resultsmentioning

confidence: 99%

“…The body of evidence shows that children with newly diagnosed cancer have markedly impaired cardiorespiratory fitness, muscle strength, and physical performance compared with healthy children shortly after diagnosis. 22,[34][35][36][37][39][40][41][42][43][44][45]52 Despite the relatively consistent findings across outcomes, the certainty in the evidence is rated very low, meaning that the true effects can be markedly different from the estimated effects. Hence, additional studies exploring specific physical outcome measures within specific diagnostic groups to describe the extent of the impairments are needed.…”

Section: Discussionmentioning

confidence: 99%

“…Two studies that included data on 132 children with ALL and lymphoblastic lymphoma 34,45 reported isometric leg and ankle strength and were included in the meta-analysis illustrated in Figure 3B,C…”

Section: Muscle Strengthmentioning

confidence: 99%

“…Twelve studies (13 patient groups compared to healthy controls), including 517 children diagnosed with all types of cancer, described different aspects of physical performance, 22,[34][35][36][37][40][41][42][43][44][45]51 including: walking distance (6-Minute Walk Test), 34,39,44,45 two different measures of functional capacity (the Timed Up and Go Test 22,35,40 and Timed Up and Down Stairs), 35,44 functional mobility (Functional Mobility Assessment Scale), 36 muscle endurance (30-second Sit-to-Stand Test), 22 balance (ultrasound-based motion analysis 37 and static stand), 43 and motor skill development (Movement Assessment Battery for Children, 41,42 Bayley Scales of Infant Development, 41 I 2 = 8%) 35,44 (Figure 4C).…”

Section: Physical Performancementioning

confidence: 99%

“…Three studies made within-study comparisons to normative data. 34,39,45 Zardo et al 44 made comparisons to imputed data from the Geiger Cohort. 24 (B) Meta-analysis of the Timed Up and Go Test.…”

Section: F I G U R E 4 (A-cmentioning

confidence: 99%

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Physical capacity in children and adolescents with newly diagnosed cancer: A systematic review and meta‐analysis

Schmidt‐Andersen,

Stage,

Pouplier

et al. 2023

Pediatric Blood & Cancer

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ObjectiveTo review the body of evidence on cardiorespiratory fitness, muscle strength, and physical performance in children with newly diagnosed cancer, five databases (MEDLINE, Embase, CINAHL, CENTRAL, and Web of Science) were searched on December 19, 2022.MethodsThirteen studies, embodying 594 participants within 1 month of cancer diagnosis and 3674 healthy controls were included. Eighteen different outcomes on cardiorespiratory fitness (n = 2), muscle strength (n = 5), physical performance (n = 10), and adverse events (n = 1) were analyzed.ResultsFifteen out of 17 outcomes on physical capacity showed severe impairments compared with healthy controls. Where possible, random‐effects meta‐analysis was conducted to synthesize the results. No adverse events were reported related to testing.ConclusionChildren with cancer have impaired cardiorespiratory fitness, muscle strength, and physical performance within the first month after diagnosis. However, the evidence is based on a small number of studies with large clinical heterogeneity, limiting the certainty of evidence.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Muscle Strengthmentioning

confidence: 99%

Section: Physical Performancementioning

confidence: 99%

Section: F I G U R E 4 (A-cmentioning

confidence: 99%

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Physical capacity in children and adolescents with newly diagnosed cancer: A systematic review and meta‐analysis

Schmidt‐Andersen,

Stage,

Pouplier

et al. 2023

Pediatric Blood & Cancer

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Utilization and Cost of Outpatient Rehabilitation Services for Pediatric Patients Treated for Acute Lymphoblastic Leukemia Using a Commercial Claims Database

Gilchrist

Tanner

Finch

et al. 2023

Archives of Physical Medicine and Rehabilitation

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Evaluation of Chemotherapy Induced Peripheral Neuropathy, Sarcopenia and Fatigue in Children with Acute Lymphoblastic Leukaemia and Lymphoma in Tertiary Care Hospital, Dakshina Kannada

Singhal,

Samuel,

Kumar

et al. 2023

IJPC

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Objectives: The study aims to assess the proportion and magnitude of chemotherapy-induced peripheral neuropathy (CIPN) and other common complications reported in children with acute lymphoblastic leukemia (ALL)/ acute lymphoblastic lymphoma (LBL) undergoing chemotherapy. Material and Methods: The study included children between 5 and 18 years old with ALL/LBL undergoing chemotherapy in Tertiary Care Hospitals, Mangalore. The study was conducted using various instruments, including paediatric-modified total neuropathy scale for CIPN, handheld dynamometer for muscle strength, bioimpedance analyser for muscle mass, timed up-and-go test for physical performance, and national comprehensive cancer network (NCCN) guidelines for scoring cancer-related fatigue at 3-time points. The collected data were analysed by IBM Statistical Package for the Social Sciences version 29 using Z-scores with standard deviation for distinct ALL/LBL types. In addition, the Paired t-test compared the baseline outcome to the 3rd and 6th time points. Results: The study evaluated 25 children with ALL undergoing chemotherapy based on the UKALL 2003 protocol during their maintenance phase. The study found that 25 children experienced CIPN, with changes in sensory and pin sensibility scores at 3 and 6 months. The study found a significant change in handgrip strength, body mass index, and muscle mass at 3 months, with no significant change in physical performance over time. Fatigue scores increased from baseline to 3 months, with significant changes observed for the 7–12 years age group at 3 months but not for the 5–6 years age group at 6 months. Conclusion: Children with ALL/LBL undergoing chemotherapy experience CIPN and other side effects such as sarcopenia and fatigue. The study highlights the potential benefits of physiotherapy interventions and supportive care strategies aimed at managing the adverse effects of chemotherapy in children with ALL/LBL.

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Physical fitness throughout chemotherapy in children with acute lymphoblastic leukaemia and lymphoma

Cited by 3 publications

References 46 publications

Physical capacity in children and adolescents with newly diagnosed cancer: A systematic review and meta‐analysis

Physical capacity in children and adolescents with newly diagnosed cancer: A systematic review and meta‐analysis

Utilization and Cost of Outpatient Rehabilitation Services for Pediatric Patients Treated for Acute Lymphoblastic Leukemia Using a Commercial Claims Database

Evaluation of Chemotherapy Induced Peripheral Neuropathy, Sarcopenia and Fatigue in Children with Acute Lymphoblastic Leukaemia and Lymphoma in Tertiary Care Hospital, Dakshina Kannada

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