Physical exercise regulates apoptosis and prostatic inflammatory effects induced by high-fat diet in PPAR-alpha deleted mice

Tavares, Maria Eduarda Almeida; Veras, Allice Santos Cruz; Thorpe, Hayley H. A.; Baptista, Danilo Bianchini; Teixeira, Giovana Rampazzo

doi:10.1016/j.prostaglandins.2022.106669

Cited by 4 publications

(1 citation statement)

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“…In recent years, studying the effects of diet and exercise on the body based on intestinal microbiota has become a hot topic. High-fat diets (HFD) promote inflammatory markers such as IL-6, and TNF-α, and increase the risk of liver toxicity, leading to dysfunctional energy metabolism and causing metabolic disease and inflammation [ 43 – 45 ]. Chronic physical fatigue impairs normal body functions, leading to endocrine disruption and decreased immunity [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Diarrhea accompanies intestinal inflammation and intestinal mucosal microbiota dysbiosis during fatigue combined with a high-fat diet

et al. 2023

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Objective It was reported fatigue or a high-fat diet triggers diarrhea, and intestinal microbiota may play central roles in diarrhea. Therefore, we investigated the association between the intestinal mucosal microbiota and the intestinal mucosal barrier from fatigue combined with a high-fat diet. Method This study divided the Specific pathogen-free (SPF) male mice into the normal group (MCN) and the standing united lard group (MSLD). The MSLD group stood on water environment platform box for 4 h/day for 14 days, and 0.4 mL lard was gavaged from day 8, twice daily for 7 days. Result After 14 days, Mice in the MSLD group showed diarrhea symptoms. The pathological analysis showed structural damage to the small intestine in the MSLD group, with an increasing trend of interleukin-6 (IL-6) and IL-17, and inflammation accompanied by structural damage to the intestine. Fatigue combined with a high-fat diet considerably decreased Limosilactobacillus vaginalis and Limosilactobacillus reuteri, and among them, Limosilactobacillus reuteri positively associated with Muc2 and negatively with IL-6. Conclusion The interactions between Limosilactobacillus reuteri and intestinal inflammation might be involved in the process of intestinal mucosal barrier impairment in fatigue combined with high-fat diet-induced diarrhea.

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Section: Discussionmentioning

confidence: 99%