2018
DOI: 10.18632/aging.101420
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: Amino acid (AA) availability is a rate-limiting factor in the regulation of muscle protein metabolism and, consequently, a risk factor for age-related decline in muscle performance. AA transporters are emerging as sensors of AA availability and activators of mTORC1 signalling, acting as transceptors. Here, we evaluated the association of 58 single nucleotide polymorphisms (SNPs) in 10 selected AA transporter genes with parameters of physical performance (Hand Grip, Activity of Daily Living, Walking time). By a… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
5
0

Year Published

2022
2022
2022
2022

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 5 publications
(5 citation statements)
references
References 39 publications
(41 reference statements)
0
5
0
Order By: Relevance
“…Interestingly, perturbed levels of both glutamine and leucine are reported in people with T2D with respect to non-diabetic subjects [ 11 , 12 ]. It is also interesting to note that in elderly subjects the same allelic variants of SLC7A5 -rs731710 and SLC7A8 -rs3783436 were found associated with better physical performance [ 21 ], reported to be impaired in people with diabetes [ 46 ]. Overall, results so far indicate that genetic variability of AAT genes may contribute to diabetes development, most likely by affecting mTORC1 activity in multiple metabolic organs such as the pancreas, liver, and skeletal muscle.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Interestingly, perturbed levels of both glutamine and leucine are reported in people with T2D with respect to non-diabetic subjects [ 11 , 12 ]. It is also interesting to note that in elderly subjects the same allelic variants of SLC7A5 -rs731710 and SLC7A8 -rs3783436 were found associated with better physical performance [ 21 ], reported to be impaired in people with diabetes [ 46 ]. Overall, results so far indicate that genetic variability of AAT genes may contribute to diabetes development, most likely by affecting mTORC1 activity in multiple metabolic organs such as the pancreas, liver, and skeletal muscle.…”
Section: Discussionmentioning
confidence: 99%
“…For the current study, seventeen SNPs from eight different AAT genes were analyzed, whose basic characteristics are reported in Supplementary Table S1 . Candidate genetic variants in AAT genes were selected from a previously study in which significant genetic associations with parameters related to the decline in muscle function and mass in the elderly were identified [ 21 ].…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Single nucleotide polymorphisms (rs357629, rs357618) in the PAT1 transporter have been found to affect its function for instance. 38 Similarly, a single nucleotide polymorphism (rs555044) was found to influence the function of GAT2 (SLC6A13), a transporter protein in the liver, responsible for GABA transport. 39 Next to GABA, tomatoes are also very rich in glutamate, one of the other main neurotransmitters and the precursor of GABA.…”
Section: Food and Function Accepted Manuscriptmentioning
confidence: 99%
“…Consistent with the roles for mTORC1 in aging [ 171 , 172 , 173 , 174 , 175 ], emerging evidence suggests that modulation of the activity of amino acid sensors, such as the ones described here, could be an effective strategy to influence rates of aging [ 206 ]. Indeed, polymorphisms in genes encoding amino acid transporters are associated with age-related changes in physical performance (e.g., grip strength and walking speed) [ 207 ]. Conversely, there is increased abundance of amino acid transporters such as SLC7A5, SLC1A5, and SLC38A5 in inflammation and cancer [ 204 , 205 , 206 , 208 ].…”
Section: Regulation Of Lifespan By Ion Channels Involved In Autophagy...mentioning
confidence: 99%