Physical Condition, Glycemia, Liver Function, and Quality of Life in Liver Transplant Recipients After a 12-Month Supervised Exercise Program

Totti, Valentina; Tamé, Mariarosa; Burra, Patrizia; Mosconi, Giovanni; Roi, Giulio Sergio; Sella, Gianluigi; Ermolao, Andrea; Ferrarese, Alberto; Sgarzi, Sergio; Savino, Gustavo; Parodi, Gíovanní; Poggioli, Giacomo; Ricchiuti, A.; Michele, Rocco Di; Trerotola, Manuela; Costa, Alessandro Nanni

doi:10.1016/j.transproceed.2019.03.087

Cited by 18 publications

(23 citation statements)

References 25 publications

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“…Interestingly, some Authors reported how patients receiving appropriate pharmacotherapy for early post-transplant depression had similar long-term survival rates to non-depressed liver-transplant recipients[ 54 ]. In addition, a recent Italian study reported how a personalized aerobic and strength training program not only improved metabolic aspects, but also the QoL perception in LT patients, so lifestyle modifications should probably be considered part of mental health management in these patients[ 55 ].…”

Section: Psychological Aspects and Quality Of Lifementioning

confidence: 99%

Main factors influencing long-term outcomes of liver transplantation in 2022

Fuochi¹,

Anastasio²,

Lynch³

et al. 2023

World J Hepatol

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Liver transplant (LT) outcomes have markedly improved in the recent decades, even if long-term morbidity and mortality are still considerable. Most of late deaths are independent from graft function and different comorbidities, including complications of metabolic syndrome and de novo neoplasms, seem to play a key role in determining long-term outcomes in LT recipients. This review discusses the main factors associated with late mortality and suggests possible strategies to improve long-term management and follow-up after liver transplantation. In particular, the reduction of drug toxicity, the use of tools to identify high-risk patients, and setting up a multidisciplinary team also for long-term management of LT recipients may further improve survival after liver transplantation.

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Section: Psychological Aspects and Quality Of Lifementioning

confidence: 99%

Main factors influencing long-term outcomes of liver transplantation in 2022

Fuochi¹,

Anastasio²,

Lynch³

et al. 2023

World J Hepatol

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“…Lifestyle modifications and a lowcalorie diet represent the cornerstone of weight gain prevention after LT. Moreover, supervised physical activity is considered safe after LT in stable patients 66 and effective for glucose homeostasis, 67 which could be particularly beneficial in patients transplanted for NAFLD/NASH-related liver disease.…”

Section: Kidney Dysfunctionmentioning

confidence: 99%

NAFLD and liver transplantation: Disease burden, current management and future challenges

2020

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Non-alcoholic fatty liver disease (NAFLD), specifically its progressive form non-alcoholic steatohepatitis (NASH), represents the fastest growing indication for liver transplantation in Western countries. Diabetes mellitus, morbid obesity and cardiovascular disease are frequently present in patients with NAFLD who are candidates for liver transplantation. These factors require specific evaluation, including a detailed pre-surgical risk stratification, in order to improve outcomes after liver transplantation. Moreover, in the post-transplantation setting, the incidence of cardiovascular events and metabolic complications can be amplified by immunosuppressive therapy, which is a well-known driver of metabolic alterations. Indeed, patients with NASH are more prone to developing early post-transplant complications and, in the long-term, de novo malignancy and cardiovascular events, corresponding to higher mortality rates. Therefore, a tailored multidisciplinary approach is required for these patients, both before and after liver transplantation. Appropriate candidate selection, lifestyle modifications and specific assessment in the pre-transplant setting, as well as pharmacological strategies, adjustment of immunosuppression and a healthy lifestyle in the post-transplant setting, play a key role in correct management.

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“…2b). In terms of outcome assessment, all studies [18][19][20]26,27] except the one conducted by Morkane et al [24] had an unclear risk of bias. The level of evidence of the studies included in this review was level 2 in five studies [21][22][23][24]28], level 3 in two studies [24,26], and level 4 in four studies [18][19][20]27].…”

Section: Risk Of Bias and Level Of Evidencementioning

confidence: 99%

Effects of supervised exercise on aerobic capacity and quality of life in patients with chronic liver disease and patients who underwent liver transplantation: a systematic review and meta-analysis

Choo

Cho²,

Lee

2021

International Journal of Rehabilitation Research

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Chronic liver disease and liver transplantation are risk factors for poor physical health and quality of life. This meta-analysis aimed to examine whether supervised exercise improves the physical health and quality of life in patients with chronic liver disease and liver transplant. Articles were searched in four databases (MEDLINE, Cochrane, Embase, and the Web of Science) from 1 January 1990 to 6 July 2021. Studies that assessed the change in aerobic capacity and quality of life following supervised exercise in patients with chronic liver disease or in those who had undergone liver transplantation were included in this meta-analysis. The two independent reviewers extracted data and the methodological quality of the included studies was assessed by the Cochrane Handbook for Systematic Reviews of Interventions. The extracted data were statistically analyzed using review management software (RevMan 5.3). The metaanalysis included 11 studies, comprising 159 patients. We observed that aerobic capacity measured as VO 2 peak and 6-min walking test improved in patients with chronic liver disease and liver transplant after supervised exercise. Among the parameters of Short-form-36 (SF-36) used for measuring the quality of life, only physical functioning improved after supervised exercise. The other parameters of SF-36 including role-physical, bodily pain, general health, vitality, social functioning, role-emotional, and mental health were not significantly improved after supervised exercise. Supervised exercise seems essential for patients with chronic liver disease and liver transplant. It was found to be helpful in enhancing the aerobic capacity and physical function in these patients.

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Physical Condition, Glycemia, Liver Function, and Quality of Life in Liver Transplant Recipients After a 12-Month Supervised Exercise Program

Cited by 18 publications

References 25 publications

Main factors influencing long-term outcomes of liver transplantation in 2022

Main factors influencing long-term outcomes of liver transplantation in 2022

NAFLD and liver transplantation: Disease burden, current management and future challenges

Effects of supervised exercise on aerobic capacity and quality of life in patients with chronic liver disease and patients who underwent liver transplantation: a systematic review and meta-analysis

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