Physical Characterization and Stability of a Microemulsion for Potential Oral Administration of a Peptide

The Role of Epidermal Growth Factor Formulation on Stress Ulcer Healing of the Gastric Mucosa

“…EGF has been reported to inhibit acid secretion, exert a trophic effect on gastroduodenal mucosa, and accelerate gastroduodenal ulcer healing. 9,16 It is also thought to play an important role in the healing of stress-induced ulceration. 17,18 Various routes of administering EGF have been studied; however, there are conflicting results about the efficacy of different routes of administering this peptide on bowel mucosa.…”

“…9 Briefly, we mixed the four different constituents including a surfactant, a cosurfactant, oil, and water. Arlacel 186 (glycerol monooleate-propylene glycol) and Brij 35 (polyoxyethylene lauryl ether) (ICI Pharmaceuticals, UK) were used as surfactants.…”

Evaluation of microemulsion and liposomes as carriers for oral delivery of transforming growth factor alpha in rats

“…Preparation and characterisation of the microemulsion The microemulsion (w/o) was prepared by modifying the microemulsion formulation that was described in our previous study (Türky|lmaz et al, 1998). Arlacel 186 and Brij 35 (S) were chosen as surfactants (S).…”

The Role of Transforming Growth Factor α Formulation on Aspirin-Induced Ulcer Healing and Oxidant Stress in the Gastric Mucosa

“…13 The microemulsion formulation was prepared using Labrafil M 1944CS, Arlacel 186:Brij 35 (5 : 1), absolute alcohol, and bidistilled water as the oil phase surfactant, cosurfactant, and aqueous phase, respectively. 11 Next, 133 µg TGF-α was added to 100 ml ME.…”