Physical activity, airway resistance and small airway dysfunction in severe asthma

Bahmer, Thomas; Waschki, Benjamin; Schatz, Fee; Herzmann, Christian; Zabel, P.; Kirsten, Anne-Marie; Rabe, Klaus F.; Watz, Henrik

doi:10.1183/13993003.01827-2016

Cited by 46 publications

(51 citation statements)

References 15 publications

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“…Thus, the duration of data collection in our study is in line with the recommendation. Interestingly, the number of SPD walked by patients with severe asthma in our study was similar to that reported by Bahmer et al and Cordova‐Rivera et al for patients with severe asthma …”

Section: Discussionsupporting

confidence: 92%

“…The device was positioned on the upper right arm, at the midpoint between the acromion and the olecranon. This multiaxial device has been validated in diverse populations, including patients with chronic diseases . DL PA was assessed by measuring four parameters: the average number of steps per day (SPD), the average time (min/day) spent in activities with an estimated EE of ≥3 metabolic equivalents (METs), the average EE spent in activities requiring ≥3 METs (kcal/day), and the average total daily EE (kcal/day).…”

Section: Methodsmentioning

confidence: 99%

“…Few studies have objectively evaluated daily life physical activity (DL PA ) levels in patients with asthma. Recently, Bahmer et al and Cordova‐Rivera et al, using objective DL PA parameters, also reported that physical activity was reduced in severe asthma patients. van't Hul et al studied a large group of adults with bronchial asthma and found lower than average values for the number of steps per day, total energy expenditure (EE), and time spent in intensive physical activity; however, the study did not include patients with severe asthma .…”

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

Factors associated with daily life physical activity in patients with asthma

Hennegrave

Fry

Behal

et al. 2018

Health Science Reports

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Factors associated with daily life physical activity in patients with asthma

Hennegrave

Fry

Behal

et al. 2018

Health Science Reports

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“…Therefore, measures of daily physical activity might assist clinicians in the functional evaluation of their patients, and identify those patients that are potentially harmed by their disease. In our study, the average number of steps per day among patients with sarcoidosis was about 7,500, which is very similar to that among patients with mild-to-moderate asthma with comparable demographics (i.e., 7,831), but probably also not significantly reduced when compared to a healthy population (i.e., 8,912) [17]. Most of the patients in our cohort regularly visited our outpatient tertiary care center after an acute onset of sarcoidosis requiring immuno-suppressive therapy and/or for second opinion, and showed minimal impairments of lung function or exercise capacity only.…”

Section: Discussionsupporting

confidence: 59%

“…The armband is worn on the upper left arm over the triceps muscle and incorporates amongst other things a triaxial accelerometer that records the average number of steps per day; those are related to key functional characteristics and quality-of-life measures in chronic obstructive pulmonary disease [10,16], asthma [17], idiopathic pulmonary fibrosis [8], and lymphangioleiomyomatosis [9]. We instructed the patients to wear the armband 24 h a day, except for the time spent on personal hygiene.…”

Section: Physical Activitymentioning

confidence: 99%

Physical Activity and Fatigue in Patients with Sarcoidosis

Bahmer

Watz

Develaska³

et al. 2017

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Background:Little is known about physical activity in daily life among patients with sarcoidosis. Fatigue is a frequent and disabling symptom that might negatively affect physical activity levels. Methods: In patients with sarcoidosis, we measured physical activity (steps per day) by accelerometry (SenseWear Armband) for 1 week. We assessed lung function (DLCO, FVC), exercise capacity (6-min walking distance . Results: We investigated 57 patients with sarcoidosis (mean age 50 years, 56% male, mean DLCO 73% predicted, mean FVC 91% predicted, mean 6MWD 525 m, mean steps per day 7,490), of whom n = 14 (25%) had severe fatigue. The MFI-20 subscales "reduced activity" and "physical fatigue" were weakly associated with steps per day on a bivariate level (Spearman ρ = -0.274 and ρ = -0.277, respectively; p < 0.05), while the other subscales and the total score were not. 6MWD, SGRQ score, and SF-12 (physical health) score showed stronger associations with steps per day in bivariate analyses (Pearson r = 0.499, r = -0.386, and r = 0.467, respectively; p < 0.01), and were independent predictors of steps per day in multivariate linear regression analyses adjusting for confounders (p < 0.05). In ROC curve analyses, 6MWD, SGRQ score, and SF-12 (physical health) score properly identified sedentary patients (steps per day <5,000; AUROC 0.90, 0.81, and 0.80, respectively; p < 0.01). Fatigue was less predictive (MFI-20 subscale "general fatigue," AUROC 0.70; p = 0.03). Conclusion: While exercise capacity and quality of life measurements were robust predictors of physical activity in patients with sarcoidosis, associations of objectively measured physical activity with fatigue were surprisingly weak. In sarcoidosis, fatigue might not preclude affected patients from being physically active, although this symptom is subjectively perceived as highly disabling.

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Olfactory decline develops in parallel with frailty in older US adults with obstructive lung diseases

Wang,

Wroblewski,

McClintock

et al. 2023

Int Forum Allergy Rhinol

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BackgroundFrailty is prevalent among older adults with asthma or chronic obstructive pulmonary disease (obstructive lung diseases [OLDs]). Frailty and OLD's co‐occurrence is associated with increased hospitalization/mortality. Chemosensory dysfunction is closely connected to both OLD and frailty. We evaluated the utility of olfactory decline as a biomarker of frailty in the setting of OLD.MethodsWe performed a prospective, longitudinal, nationally representative study of community‐dwelling older US adults in the National Social Life, Health and Aging Project, an omnibus in‐home survey. Respondents reported a physician's diagnosis of OLD. Decline in odor identification and sensitivity over 5 years and frailty (adapted fried frailty phenotype criteria) were measured using standard tools. Multivariate logistic regressions evaluated the association between OLD status, olfactory decline, and frailty.ResultsWe compared individuals with OLD (n = 98; mean age 71.2 years, 59.2% women) and those without OLD (n = 1036; mean age 69.5 years, 58.9% women). Olfactory identification decline was associated with developing frailty over the 5‐year follow‐up period in individuals with OLD (odds ratio [OR] = 9.1, 95% confidence interval [CI] = 2.1–38.6, p = 0.003). Olfactory decline predicted incidence of frailty in individuals with OLD (identification: OR = 4.8, 95% CI = 1.3–17.5, P = 0.018; sensitivity: OR = 6.1, 95%CI = 1.2–31.0, p = 0.030) but not in those without OLD adjusting for demographics, heavy alcohol use, current smoking, and comorbidity. Results were robust to different thresholds for olfactory decline and frailty development.ConclusionsOlder adults with OLD who experience olfactory decline face higher odds of developing frailty. Use of olfactory decline as a biomarker to identify frailty could allow earlier intervention and decrease adverse outcomes for high‐risk older adults with OLD.

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Physical activity, airway resistance and small airway dysfunction in severe asthma

Cited by 46 publications

References 15 publications

Factors associated with daily life physical activity in patients with asthma

Factors associated with daily life physical activity in patients with asthma

Physical Activity and Fatigue in Patients with Sarcoidosis

Olfactory decline develops in parallel with frailty in older US adults with obstructive lung diseases

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