Phylogenetic relationships of rat lungworm, Angiostrongylus cantonensis, isolated from different geographical regions revealed widespread multiple lineages

Tokiwa, Toshihiro; Harunari, Tsunehito; Tamada, Tsutomu; Komatsú, Noriyuki; Koizumi, Nobuo; Tung, Kwong‐Chung; Suzuki, Jun; Kadosaka, Teruki; Takada, Nobuhiro; Kumagai, Toru; Akao, Nobuaki; Ohta, Nobuhiro

doi:10.1016/j.parint.2012.02.005

Cited by 49 publications

(74 citation statements)

References 35 publications

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“…Subsequently, Monte et al (2012) [22] found the presence of 3 distinct haplotypes (ac5, ac8, and ac9) in Brazil. These results supports that the appearance of A. cantonensis in these regions is likely a results of multiple introduction of infected hosts via human related transportation [20], [22].…”

Section: Introductionsupporting

confidence: 81%

“…Nuclear small subunit (SSU) rRNA sequences generally show little variation within a nematode species, but substantial divergence among species, allowing for species differentiation [9], [19], [20]. On the other hand, the mitochondrial cytochrome c oxidase subunit I ( coxI ) gene has proved to be a powerful marker in resolving phylogenetic relationships within closely related Angiostrongylus species [20], [21], and has provided further information to increase understanding of the genetic differences among A. cantonensis isolates [20], [22].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the mitochondrial cytochrome c oxidase subunit I ( coxI ) gene has proved to be a powerful marker in resolving phylogenetic relationships within closely related Angiostrongylus species [20], [21], and has provided further information to increase understanding of the genetic differences among A. cantonensis isolates [20], [22]. In a previous study, we showed the presence of 7 distinct haplotypes (ac1, ac2, ac3, ac4, ac5, ac6, and ac7) of the A. cantonensis coxI gene in Asia [20]. Subsequently, Monte et al (2012) [22] found the presence of 3 distinct haplotypes (ac5, ac8, and ac9) in Brazil.…”

Section: Introductionmentioning

confidence: 99%

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First Report of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae) Infections in Invasive Rodents from Five Islands of the Ogasawara Archipelago, Japan

Tokiwa

Hashimoto

Yabe³

et al. 2013

PLoS ONE

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Background Angiostrongylus cantonensis (Chen, 1935) is a parasite of murid rodents and causative agent of human neuro-angiostrongyliasis. In 2011, the Ogasawara Islands in the western North Pacific were assigned a World Natural Heritage site status. The occurrence of A. cantonensis is well documented in the Chichijima, Hahajima, and Anijima Islands. However, the occurrence of A. cantonensis in the other islands of the Ogasawara Islands has not been reported.Methodology/Principal FindingsBetween March 2010 and July 2011, 57 Rattus norvegicus and 79 R. rattus were collected from 9 islands (the Hahajima group: Anejima, Imoutojima, Meijima, Mukohjima, and Hirajima; Chichijima group: Minamijima; Mukojima group: Nakoudojima and Yomejima; and Iwojima group: Iwojima). Adult nematodes were found in the pulmonary artery of 46 R. norvegicus collected in the 5 islands of the Hahajima group (Anejima, Meijima, Imoutojima, Hrajima, and Mukohjima Islands). These nematodes were identified by molecular analysis as A. cantonensis. Comparison of the mitochondrial DNA sequences confirmed that all the samples from the Ogasawara Islands shared only a single lineage of A. cantonensis, which has been previously detected in the Okinawa, Hawaii, and Brazil.Conclusions/SignificanceWe describe new endemic foci of rat angiostrongyliasis in the Hahajima group (Anejima, Meijima, Imoutojima, Hirajima, and Mukohjima Islands) of the Ogasawara Islands. These findings indicate that the endemic foci of A. cantonensis are widely distributed in the Ogasawara Islands. Although human cases have not yet been reported in the Ogasawara Islands, the widespread detection of A. cantonensis could be of importance from the perspective of public health.

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Section: Introductionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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First Report of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae) Infections in Invasive Rodents from Five Islands of the Ogasawara Archipelago, Japan

Tokiwa

Hashimoto

Yabe³

et al. 2013

PLoS ONE

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“…Smith and Carpenter (2006) norvegicus (Monte et al 2012, Tokiwa et al 2012) and the invasion of the terrestrial snail Achatina fulica which acts as an intermediate host .…”

Section: Spillover Cases May Also Include Parasitic Protists For Examentioning

confidence: 99%

Global parasite and Rattus rodent invasions: The consequences for rodent‐borne diseases

Morand

Bordes

Chen

et al. 2015

Integrative Zoology

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We summarize the current knowledge on parasitism-related invasion processes of the globally invasive Rattus lineages, originating from Asia, and how these invasions have impacted the local epidemiology of rodent-borne diseases. Parasites play an important role in the invasion processes and successes of their hosts through multiple biological mechanisms such as "parasite release", "immunocompetence advantage", "biotic resistance" and "novel weapon".Parasites may also greatly increase the impact of invasions by spillover of parasites and other pathogens, introduced with invasive hosts, into new hosts potentially leading to novel emerging diseases. Another potential impact is the ability of the invader to amplify local parasites by spill-back. In both cases, local fauna and humans may be exposed to new health risks, which may decrease biodiversity and may potentially cause increases in human morbidity and mortality. Here we review the current knowledge on these processes and propose some research priorities.

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“…For example, ribosomal DNA sequences were used to assess metastrongylid nematode relationships (Carreno & Nadler, 2003) or to help survey larvae from mollusk intermediate hosts (Fontanilla & Wade, 2008; Qvarnstrom, Sullivan, Bishop, Hollingsworth, & da Silva, 2007; Qvarnstrom et al., 2010), and ~360‐bp region of the cytochrome c oxidase 1 ( CO 1) gene was used to assess relationships to other species of Angiostrongylus (Eamsobhana et al., 2010). To date, molecular systematic/phylogeographic studies on A. cantonensis have mainly used two mitochondrial (mtDNA) markers, CO 1 and cytochrome b ( CYTB ), where the focus has largely been descriptive in terms of reporting local patterns of haplotype variants (Aghazadeh et al., 2015; Dalton, Fenton, Cleveland, Elsmo, & Yabsley, 2017; Dusitsittipon, Criscione, Morand, Komalamisra, & Thaenkham, 2017; Dusitsittipon, Thaenkham, Watthanakulpanich, Adisakwattana, & Komalamisra, 2015; Eamsobhana, Song, et al., 2017; Eamsobhana, Yong, et al., 2017; Lv et al., 2012; Monte et al., 2012; Moreira et al., 2013; Nakaya et al., 2013; Okano et al., 2014; Rodpai et al., 2016; Simoes et al., 2011; Tokiwa et al., 2012, 2013; Vitta et al., 2016; Yong, Eamsobhana, Song, Prasartvit, & Lim, 2015; Yong, Song, Eamsobhana, Goh, & Lim, 2015; Yong, Song, Eamsobhana, & Lim, 2016). …”

Section: Introductionmentioning

confidence: 99%

Hurdles in the evolutionary epidemiology of Angiostrongylus cantonensis: Pseudogenes, incongruence between taxonomy and DNA sequence variants, and cryptic lineages

Dusitsittipon

Criscione

Morand

et al. 2018

Evolutionary Applications

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Angiostrongylus cantonensis, the rat lungworm, is a zoonotic pathogen that is one of the leading causes of eosinophilic meningitis worldwide. This parasite is regarded as an emerging pathogen with a global range expansion out of southeastern Asia post‐WWII. To date, molecular systematic/phylogeographic studies on A. cantonensis have mainly used two mitochondrial (mtDNA) markers, cytochrome c oxidase 1 (CO1) and cytochrome b (CYTB), where the focus has largely been descriptive in terms of reporting local patterns of haplotype variants. In order to look for more global evolutionary patterns, we herein provide a collective phylogenetic assessment using the six available whole mtDNA genome samples that have been tagged as A. cantonensis, A. malaysiensis, or A. mackerrasae along with all other GenBank CO1 and CYTB partial sequences that carry these species identifiers. The results reveal three important complications that researchers will need to be aware of, or will need to resolve, prior to conducting future molecular evolutionary studies on A. cantonensis. These three problems are (i) incongruence between taxonomic identifications and mtDNA variants (haplotypes or whole mtDNA genome samples), (ii) the presence of a CYTB mtDNA pseudogene, and (iii) the need to verify A. mackerrasae as a species along with other possible cryptic lineages, of which there is suggestive evidence (i.e., A. cantonensis could be a species complex). We provided a discussion of how these complications are hurdles to our understanding of the global epidemiology of angiostrongyliasis. We call for future studies to be more explicit in morphological traits used for identifications (e.g., provide measurements). Moreover, it will be necessary to repeat prior morphological and life‐history studies while simultaneously using sequence data in order to assess possible associations between critical epidemiological data (e.g., biogeography, virulence/pathology, host species use) and specific lineages.

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Phylogenetic relationships of rat lungworm, Angiostrongylus cantonensis, isolated from different geographical regions revealed widespread multiple lineages

Cited by 49 publications

References 35 publications

First Report of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae) Infections in Invasive Rodents from Five Islands of the Ogasawara Archipelago, Japan

First Report of Angiostrongylus cantonensis (Nematoda: Angiostrongylidae) Infections in Invasive Rodents from Five Islands of the Ogasawara Archipelago, Japan

Global parasite and Rattus rodent invasions: The consequences for rodent‐borne diseases

Hurdles in the evolutionary epidemiology of Angiostrongylus cantonensis: Pseudogenes, incongruence between taxonomy and DNA sequence variants, and cryptic lineages

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