2009
DOI: 10.1590/s1516-31802009000300003
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Phylogenetic classification of human papillomavirus genotypes in high-grade cervical intraepithelial neoplasia in women from a densely populated Brazilian urban region

Abstract: CONTEXT AND OBJECTIVE: Differences in human papillomavirus (HPV) types may correlate with the biological potential and invasion risk of high-grade cervical intraepithelial neoplasia (CIN 2 and CIN 3). The objective of this study was to determine the relationship between different combinations of HPV types and CIN severity. DESIGN AND SETTING:Cross-sectional study, at Universidade Estadual de Campinas (Unicamp). METHODS:Cervical samples from 106 women treated due to CIN 2 (18) or CIN 3 (88) were examined for sp… Show more

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Cited by 7 publications
(5 citation statements)
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References 26 publications
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“…Some prevalence studies have indicated that the DNA of HPV 52 is present in approximately 2% of all cases of cervical squamous intraepithelial lesions 28,29 and that the presence of HPV 58 for these lesions ranges from 6% to 20%, which is the range within which these genotypes were detected in our work 13,24,25,26 .…”
Section: Discussionsupporting
confidence: 58%
“…Some prevalence studies have indicated that the DNA of HPV 52 is present in approximately 2% of all cases of cervical squamous intraepithelial lesions 28,29 and that the presence of HPV 58 for these lesions ranges from 6% to 20%, which is the range within which these genotypes were detected in our work 13,24,25,26 .…”
Section: Discussionsupporting
confidence: 58%
“…Curiously, at least one HR-HPV was present in all cases of multiple infections. Pitta et al (2009) observed that in a Brazilian population, multiple infections reached a prevalence of 64.7% with a strong association with HPV 16 and 58, followed by an association with HPV 16 and 52, which is contradictory to the results of the present study. In the updated meta-analysis of Ciapponi et al (2011), it was found a prevalence of 16.8% multiple infections in high-grade lesions in Latin America and the Caribbean, with cases mainly from Brazil, whilst in the present study we found 24.3% of multiple infections.…”
Section: Discussioncontrasting
confidence: 99%
“…25 Pitta et al (2009) reported that women infected with alpha-9 HPV were more likely to have CIN 3 than those infected with alpha-7 HPV or other genotypes. 6 Cross-sectional population-based data from the POBASCAN study revealed that the risk of CIN 3 is increased for HPV 16 and 33 (alpha-9 HPV), but not for HPV 18 and 45 (alpha-7 HPV). 26…”
Section: Discussionmentioning
confidence: 99%
“…4 There are indications that HPV types belonging to the alpha-9 species occur more often in multiple infections and are correlated with more severe lesions. 47…”
Section: Introductionmentioning
confidence: 99%