Phyllanthus species for chronic hepatitis B virus infection

Antimicrobial activity of Phyllanthus niruri (Chanka piedra)

“…39,40 Although, no systematic reviews have been conducted on the anti-hepatitis B activity of P. niruri, there have been a number of reviews since 2000, on the utility of Phyllanthus genus as potential antiviral agents for chronic hepatitis B infection. [41][42][43] Despite the promising results with respect to the inhibition of HIV-1RT activity, repandusinic acid seemed to exert less significant inhibition of DNA polymerase alpha. 44 With regard to the resultant degree of cytopathogenicity, repandusinic acid reduced the number of pathogenic changes in HIV infected MT4 cells, and the results even suggested that repandusinic acid may be more potent than AZT in inhibiting HIV cytopathogenicity.…”

Antimicrobial activity of Phyllanthus niruri (Chanka piedra)

“…39,40 Although, no systematic reviews have been conducted on the anti-hepatitis B activity of P. niruri, there have been a number of reviews since 2000, on the utility of Phyllanthus genus as potential antiviral agents for chronic hepatitis B infection. [41][42][43] Despite the promising results with respect to the inhibition of HIV-1RT activity, repandusinic acid seemed to exert less significant inhibition of DNA polymerase alpha. 44 With regard to the resultant degree of cytopathogenicity, repandusinic acid reduced the number of pathogenic changes in HIV infected MT4 cells, and the results even suggested that repandusinic acid may be more potent than AZT in inhibiting HIV cytopathogenicity.…”

Phytotherapy and Liver Disease

“…The lack of relevant clinical trials prevents making any conclusions on hepatoprotective effect of plants from this family. Nevertheless, rare research on patients showed that Phyllanthus amarus is not effective in the treatment of viral hepatitis [67], whereas glycyrrhizin a triterpenic ingredient in Glycyrrhizin glabra successfully reduced HCV titer in vitro [68]. In combination with interferon, glycyrrhizin showed synergic effect.…”

The pharmacological potential ofPhyllanthus niruri

“…To date, no systematic review has been conducted on the anti‐hepatitis B activity of P. niruri per se . However, there have been a number of reviews since the year 2000, on the utility of members of the Phyllanthus genus as potential antiviral agents for chronic hepatitis B infection . One review concluded that Phyllanthus extracts were as effective as interferon in the terms of HBsAg seroconversion.…”

“…Subsequent reviews have concluded that while there is insufficient evidence to suggest that the extracts of Phyllanthus are, by themselves, comparable in efficacy to current antiviral agents, and hence justify their use in chronic hepatitis B patients, such extracts may enhance the potency of an antiviral agent if used in combination . Despite these evidences, to justify the use of Phyllanthus for chronic hepatitis B patients, there is a need for more high‐powered studies to assess the effectiveness of Phyllanthus against current antiviral therapy.…”

Antimicrobial activity of Phyllanthus niruri (Chanka piedra)

“…39,40 Although, no systematic reviews have been conducted on the anti-hepatitis B activity of P. niruri, there have been a number of reviews since 2000, on the utility of Phyllanthus genus as potential antiviral agents for chronic hepatitis B infection. [41][42][43] Despite the promising results with respect to the inhibition of HIV-1RT activity, repandusinic acid seemed to exert less significant inhibition of DNA polymerase alpha. 44 With regard to the resultant degree of cytopathogenicity, repandusinic acid reduced the number of pathogenic changes in HIV infected MT4 cells, and the results even suggested that repandusinic acid may be more potent than AZT in inhibiting HIV cytopathogenicity.…”

Phytotherapy and Liver Disease

“…The lack of relevant clinical trials prevents making any conclusions on hepatoprotective effect of plants from this family. Nevertheless, rare research on patients showed that Phyllanthus amarus is not effective in the treatment of viral hepatitis [67], whereas glycyrrhizin a triterpenic ingredient in Glycyrrhizin glabra successfully reduced HCV titer in vitro [68]. In combination with interferon, glycyrrhizin showed synergic effect.…”

The pharmacological potential ofPhyllanthus niruri

“…To date, no systematic review has been conducted on the anti‐hepatitis B activity of P. niruri per se . However, there have been a number of reviews since the year 2000, on the utility of members of the Phyllanthus genus as potential antiviral agents for chronic hepatitis B infection . One review concluded that Phyllanthus extracts were as effective as interferon in the terms of HBsAg seroconversion.…”

“…Subsequent reviews have concluded that while there is insufficient evidence to suggest that the extracts of Phyllanthus are, by themselves, comparable in efficacy to current antiviral agents, and hence justify their use in chronic hepatitis B patients, such extracts may enhance the potency of an antiviral agent if used in combination . Despite these evidences, to justify the use of Phyllanthus for chronic hepatitis B patients, there is a need for more high‐powered studies to assess the effectiveness of Phyllanthus against current antiviral therapy.…”

Antimicrobial activity of Phyllanthus niruri (Chanka piedra)

“…39,40 Although, no systematic reviews have been conducted on the anti-hepatitis B activity of P. niruri, there have been a number of reviews since 2000, on the utility of Phyllanthus genus as potential antiviral agents for chronic hepatitis B infection. [41][42][43] Despite the promising results with respect to the inhibition of HIV-1RT activity, repandusinic acid seemed to exert less significant inhibition of DNA polymerase alpha. 44 With regard to the resultant degree of cytopathogenicity, repandusinic acid reduced the number of pathogenic changes in HIV infected MT4 cells, and the results even suggested that repandusinic acid may be more potent than AZT in inhibiting HIV cytopathogenicity.…”

Phytotherapy and Liver Disease

“…The lack of relevant clinical trials prevents making any conclusions on hepatoprotective effect of plants from this family. Nevertheless, rare research on patients showed that Phyllanthus amarus is not effective in the treatment of viral hepatitis [67], whereas glycyrrhizin a triterpenic ingredient in Glycyrrhizin glabra successfully reduced HCV titer in vitro [68]. In combination with interferon, glycyrrhizin showed synergic effect.…”

The pharmacological potential ofPhyllanthus niruri

“…To date, no systematic review has been conducted on the anti‐hepatitis B activity of P. niruri per se . However, there have been a number of reviews since the year 2000, on the utility of members of the Phyllanthus genus as potential antiviral agents for chronic hepatitis B infection . One review concluded that Phyllanthus extracts were as effective as interferon in the terms of HBsAg seroconversion.…”

“…Subsequent reviews have concluded that while there is insufficient evidence to suggest that the extracts of Phyllanthus are, by themselves, comparable in efficacy to current antiviral agents, and hence justify their use in chronic hepatitis B patients, such extracts may enhance the potency of an antiviral agent if used in combination . Despite these evidences, to justify the use of Phyllanthus for chronic hepatitis B patients, there is a need for more high‐powered studies to assess the effectiveness of Phyllanthus against current antiviral therapy.…”