Phycobiliprotein as fluorescent probe and photosensitizer: A systematic review

Xi, Qiang; Wang, Lijun; Niu, Jianfeng; Gong, Xuerui; Wang, Guangce

doi:10.1016/j.ijbiomac.2021.11.022

Cited by 23 publications

(8 citation statements)

References 58 publications

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“…Holo-ApcA-carrying PEB was successfully produced, which showed a distinct spectral property from native holo-ApcA. PBPs are regarded as potential photosensitizers in cancer therapy [ 61 ]. The ability to produce unnatural PBP in E. coli would expand the types of PBPs and contribute to the exploration of novel photosensitizers.…”

Section: Production Of Phycobiliproteinsmentioning

confidence: 99%

“…Type I: triplet photosensitizers directly produce ROS, which aew then transformed into O 2 − , OH − or H 2 O 2 to kill cancer cells. Type II: the triplet photosensitizer reacts with triplet oxygen molecules ( 3 O 2 ) to produce singlet oxygen ( 1 O 2 ), and then deoxidizes the substrate [ 61 ]. A photosensitizer is the critical element during PDT therapy.…”

Section: Pharmaceutical Potentialsmentioning

confidence: 99%

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Phycobiliproteins—A Family of Algae-Derived Biliproteins: Productions, Characterization and Pharmaceutical Potentials

Chen

Xiong

2022

Marine Drugs

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Phycobiliproteins (PBPs) are colored and water-soluble biliproteins found in cyanobacteria, rhodophytes, cryptomonads and cyanelles. They are divided into three main types: allophycocyanin, phycocyanin and phycoerythrin, according to their spectral properties. There are two methods for PBPs preparation. One is the extraction and purification of native PBPs from Cyanobacteria, Cryptophyta and Rhodophyta, and the other way is the production of recombinant PBPs by heterologous hosts. Apart from their function as light-harvesting antenna in photosynthesis, PBPs can be used as food colorants, nutraceuticals and fluorescent probes in immunofluorescence analysis. An increasing number of reports have revealed their pharmaceutical potentials such as antioxidant, anti-tumor, anti-inflammatory and antidiabetic effects. The advances in PBP biogenesis make it feasible to construct novel PBPs with various activities and produce recombinant PBPs by heterologous hosts at low cost. In this review, we present a critical overview on the productions, characterization and pharmaceutical potentials of PBPs, and discuss the key issues and future perspectives on the exploration of these valuable proteins.

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Section: Production Of Phycobiliproteinsmentioning

confidence: 99%

Section: Pharmaceutical Potentialsmentioning

confidence: 99%

Phycobiliproteins—A Family of Algae-Derived Biliproteins: Productions, Characterization and Pharmaceutical Potentials

Chen

Xiong

2022

Marine Drugs

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“…In addition, seaweeds also contain some unique proteins, represented by Phycobiliprotein containing Phycoerythrin and Phycocyanin. It is a protein‐like pigment that can provide supplementing amino acids as nutrients, as well as exhibit high‐value bioactive functions such as anti‐inflammatory, anticancer, antioxidant and other bioactive functions (Bannu et al ., 2019; Qiang et al ., 2021).…”

Section: Prospects For Seaweed Applications In the Futurementioning

confidence: 99%

Seaweed as a sustainable future food source

Chen,

Zhang,

Liu

et al. 2024

Int J of Food Sci Tech

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SummarySeaweed is a kind of high‐quality resource with wide distribution, short growth period and variety. They contain a variety of bioactive substances, including vitamins, proteins, polysaccharides, minerals, phenols and terpenes. Seaweed is also a source of a new class of high‐quality protein, and it also contains some active ingredients not found in land plants. These bioactive substances give seaweed powerful physiological functions so that it is used in medical, food, cosmetics and other industries. At present, the development of seaweed is still relatively simple, and its application potential is far more than that. With the support of rich active substances, seaweed is considered to be a healthy food for sustainable applications in the future. On this basis, future applications such as the development of plant‐based meat, plant‐based protein and space food using seaweed are proposed in this paper.

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“…[19][20][21][22] The protein fluorescent probe with high biocompatibility, while the protein often with complex extraction process and poor penetration ability. [23] Similar to protein, peptide is formed by connecting natural or synthetic amino acids through peptide bond but with molecular weight smaller than that of protein and can be obtained by solid phase synthesis. [24] It has been reported that peptide-based fluorescent probes possess high biocompatibility and large Stokes shift.…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that the organic small molecular probes usually have small Stokes shift and short fluorescence lifetime, which usually with relative poor biocompatibility [19–22] . The protein fluorescent probe with high biocompatibility, while the protein often with complex extraction process and poor penetration ability [23] . Similar to protein, peptide is formed by connecting natural or synthetic amino acids through peptide bond but with molecular weight smaller than that of protein and can be obtained by solid phase synthesis [24] …”

Section: Introductionmentioning

confidence: 99%

A Review on Recent Advances in Peptide‐based Fluorescence Probes and their Potential Applications

Wang,

Chen

et al. 2023

ChemistrySelect

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With the development and maturity of classical solid‐state synthesis techniques, peptide synthesis has become more convenient. With the continuous progress of research in the field of life sciences, more and more peptides have been elucidated in terms of their structure and biological functions. Due to the excellent biocompatibility, specificity, selectivity, and low cytotoxicity, peptide‐based fluorescent probes have been widely explored and applied in chemical, biological, medical and other fields. This review summarized the characteristics of peptide‐based fluorescence probes in terms of long fluorescence lifetime, high stability, large Stokes shift, high fluorescence quantum yield, high selectivity and sensitivity. Several types of peptide‐based fluorescence probes, such as peptide basic fluorescence, embedded fluorescence molecules, coupled fluorescence groups, and self‐assembled fluorescence, were also described. Finally, we summarized the applications of peptide‐based fluorescent probes in biological imaging, disease detection, ion detection, and biomolecule detection. This review may provide a guarantee and inspiration for further development of the peptide‐based fluorescent probes in the field of biological applications.

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Phycobiliprotein as fluorescent probe and photosensitizer: A systematic review

Cited by 23 publications

References 58 publications

Phycobiliproteins—A Family of Algae-Derived Biliproteins: Productions, Characterization and Pharmaceutical Potentials

Phycobiliproteins—A Family of Algae-Derived Biliproteins: Productions, Characterization and Pharmaceutical Potentials

Seaweed as a sustainable future food source

A Review on Recent Advances in Peptide‐based Fluorescence Probes and their Potential Applications

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