PhXA34, a New Potent Ocular Hypotensive Drug

Effect of 0.005% latanoprost once daily on intraocular pressure in glaucomatous patients not adequately controlled by beta-blockers twice daily: a 3-year follow-up

“…Latanoprost 0.005% was effective in subjects in whom beta-blockers alone were not adequate, as documented by the mean IOP, the diurnal tonometric profile and the visual field results. These findings agree with the results of previous investigations by others [1,2,3,16,17,24,25,28,29].…”

Effect of 0.005% latanoprost once daily on intraocular pressure in glaucomatous patients not adequately controlled by beta-blockers twice daily: a 3-year follow-up

“…Latanoprost 0.005% was effective in subjects in whom beta-blockers alone were not adequate, as documented by the mean IOP, the diurnal tonometric profile and the visual field results. These findings agree with the results of previous investigations by others [1,2,3,16,17,24,25,28,29].…”

Effects on intraocular pressure and aqueous flow of various dose regimens of latanoprost in human eyes

“…As in previous studies (Alm & Villumsen 1991;Ziai et al 1993;Tons et al 1993) we found that reduction in aqueous humour production cannot explain the eye pressure lowering effect of latanoprost. In fact, we found a tendency to increased flow with all three dose regimens.…”

Bioavailability in the Human Eye of a Fixed Combination of Latanoprost and Timolol Compared to Monotherapy

“…The mechanism of action of PGF 2a compounds on IOP is mainly by increasing uveoscleral outflow. This has been shown in the cynomolgus monkey (2,3) and in humans by means of indirect measurements (4)(5)(6).…”

Effect of 0.005% latanoprost once daily on intraocular pressure in glaucomatous patients not adequately controlled by beta-blockers twice daily: a 3-year follow-up

“…Latanoprost 0.005% was effective in subjects in whom beta-blockers alone were not adequate, as documented by the mean IOP, the diurnal tonometric profile and the visual field results. These findings agree with the results of previous investigations by others [1,2,3,16,17,24,25,28,29].…”

Effects on intraocular pressure and aqueous flow of various dose regimens of latanoprost in human eyes

“…As in previous studies (Alm & Villumsen 1991;Ziai et al 1993;Tons et al 1993) we found that reduction in aqueous humour production cannot explain the eye pressure lowering effect of latanoprost. In fact, we found a tendency to increased flow with all three dose regimens.…”

Bioavailability in the Human Eye of a Fixed Combination of Latanoprost and Timolol Compared to Monotherapy

“…The mechanism of action of PGF 2a compounds on IOP is mainly by increasing uveoscleral outflow. This has been shown in the cynomolgus monkey (2,3) and in humans by means of indirect measurements (4)(5)(6).…”

Effect of 0.005% latanoprost once daily on intraocular pressure in glaucomatous patients not adequately controlled by beta-blockers twice daily: a 3-year follow-up

“…Latanoprost 0.005% was effective in subjects in whom beta-blockers alone were not adequate, as documented by the mean IOP, the diurnal tonometric profile and the visual field results. These findings agree with the results of previous investigations by others [1,2,3,16,17,24,25,28,29].…”

Effects on intraocular pressure and aqueous flow of various dose regimens of latanoprost in human eyes

“…As in previous studies (Alm & Villumsen 1991;Ziai et al 1993;Tons et al 1993) we found that reduction in aqueous humour production cannot explain the eye pressure lowering effect of latanoprost. In fact, we found a tendency to increased flow with all three dose regimens.…”

Bioavailability in the Human Eye of a Fixed Combination of Latanoprost and Timolol Compared to Monotherapy

“…The mechanism of action of PGF 2a compounds on IOP is mainly by increasing uveoscleral outflow. This has been shown in the cynomolgus monkey (2,3) and in humans by means of indirect measurements (4)(5)(6).…”