Phthalocyanines Structure Versus Photodynamic Effectiveness towards Pathogenic Microorganisms: Our Recent Experience

Mantareva, Vanya; Ангелов, Иван; Syuleyman, Meliha; Kussovski, Vesselin; Eneva, Ivelina; Avramov, L.; Borisova, Ekaterina

doi:10.18287/jbpe21.07.040202

Cited by 2 publications

(3 citation statements)

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“…The full photodynamic inactivation result (~log 6) was determined for 5 μM of ZnPcMe but with low efficiency (<log 3) at lower concentrations. These observations confirm the previous studies with ZnPcMe, with photoinactivation capacity at lower concentrations [ 26 ]. Considering the structures of both peripherally substituted complexes, the phototoxic effect of ZnPcMe was higher than that of pPdPc ( Figure 2 and Figure 4 ).…”

Section: Resultssupporting

confidence: 93%

“…The full phototoxic effect was observed with complex ZnPcMe, which is known as a highly effective photosensitizer in the photodynamic inactivation of pathogenic species, including viruses [ 24 , 25 ]. The results with A. hydrophila support the role of zinc as a proper metal ion for PDT photosensitizers [ 26 , 28 ]. Lately, it was reported that cationic photosensitizers have a high impact on the antimicrobial efficiency because of the binding ability and the charge density distribution of cationic groups [ 33 ].…”

Section: Discussionmentioning

confidence: 63%

“…As is well-studied, the bacterial wall of the Gram (−) species is more complicated, which additionally increases the resistance. The cationic phthalocyanines are well-studied as being more favorable for antibacterial PDT because of the proper electrostatic interaction of these compounds with cell membranes [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

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Photodynamic Inactivation of Antibiotic-Resistant and Sensitive Aeromonas hydrophila with Peripheral Pd(II)- vs. Zn(II)-Phthalocyanines

Mantareva

Kussovski

Orozova³

et al. 2022

Biomedicines

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The antimicrobial multidrug resistance (AMR) of pathogenic bacteria towards currently used antibiotics has a remarkable impact on the quality and prolongation of human lives. An effective strategy to fight AMR is the method PhotoDynamic Therapy (PDT). PDT is based on a joint action of a photosensitizer, oxygen, and light within a specific spectrum. This results in the generation of singlet oxygen and other reactive oxygen species that can inactivate the pathogenic cells without further regrowth. This study presents the efficacy of a new Pd(II)- versus Zn(II)-phthalocyanine complexes with peripheral positions of methylpyridiloxy substitution groups (pPdPc and ZnPcMe) towards Gram-negative bacteria Aeromonas hydrophila (A. hydrophila). Zn(II)-phthalocyanine, ZnPcMe was used as a reference compound for in vitro studies, bacause it is well-known with a high photodynamic inactivation ability for different pathogenic microorganisms. The studied new isolates of A. hydrophila were antibiotic-resistant (R) and sensitive (S) strains. The photoinactivation results showed a full effect with 8 µM pPdPc for S strain and with 5 µM ZnPcMe for both R and S strains. Comparison between both new isolates of A. hydrophila (S and R) suggests that the uptakes and more likely photoinactivation efficacy of the applied phthalocyanines are independent of the drug sensitivity of the studied strains.

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Section: Resultssupporting

confidence: 93%