Phthalate pregnancy exposure and male offspring growth from the intra-uterine period to five years of age

Botton, Jérémie; Philippat, Claire; Calafat, Antònia M.; Carles, Sophie; Munier, Charles; Slama, Rémy; group, the EDEN mother-child cohort study

doi:10.1016/j.envres.2016.08.033

Cited by 78 publications

(57 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are consistent with those of Botton et al (17), who reported that prenatal urinary concentrations of MEP were associated with increased weight growth velocity at ages 2 and 4 years and increased BMI at 5 years in French boys ( N = 520). The study by Botton et al did not include girls and could not examine interaction by sex.…”

Section: Discussionsupporting

confidence: 93%

“…Five other investigations (13–17) have used similar study designs as ours, measuring phthalate metabolites in prenatal urine and body weight in childhood, although no other study followed up children beyond 7 years of age. Our findings are consistent with those of Botton et al (17), who reported that prenatal urinary concentrations of MEP were associated with increased weight growth velocity at ages 2 and 4 years and increased BMI at 5 years in French boys ( N = 520).…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…However, only a few longitudinal studies have examined the associations of prenatal exposure and later BMI (13–17), and these studies have shown inconsistent results and often sex-specific associations. A study in France that examined only boys found that prenatal urinary concentrations of the main DEP metabolite were associated with increased BMI at age 5 years (17); however, three other studies have found prenatal phthalate metabolites to be associated with decreased BMI in boys (13–15). Specifically, a study on Spanish children found that urinary concentrations of high-molecular-weight phthalates in mothers during pregnancy were negatively associated with BMI z -score in boys at age 4 and 7 years but were positively (although non-significantly) associated with BMI z -score in girls at the same ages (16).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity

et al. 2017

View full text Add to dashboard Cite

BACKGROUND Although experiments in animals suggest that phthalates may have obesogenic effects, studies on prenatal exposure in children show inconsistent results. METHODS We measured urinary concentrations of 11 phthalate metabolites collected twice during pregnancy from mothers participating in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort study (N = 345). Height, weight, waist circumference, and percent body fat were assessed in their children between 5 and 12 years of age. We used generalized estimating equations to examine associations at each age and tested for interaction by sex. RESULTS Metabolites of diethyl phthalate (DEP), di-n-butyl phthalate (DBP), butyl benzyl phthalate, and di(2-ethylhexyl) phthalate (DEHP) were positively associated with BMI z-score, waist circumference z-score, and percent body fat at multiple ages. At age 12, we observed increased odds of being overweight/obese with each doubling of prenatal concentrations of DEP (odds ratio = 1.3; 95% confidence intervals: 1.1, 1.4), DBP (1.2; 1.0, 1.4), and DEHP (1.3; 1.0, 1.6) metabolites. Results were similar in boys and girls except for DBP metabolites and the non-specific metabolite mono-(3-carbox-ypropyl) phthalate, which showed positive associations only in boys. CONCLUSION In utero exposure to certain phthalates is associated with increased BMI and risk for overweight/obesity in childhood.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In the Eden Mother-Child Cohort study, 520 mothers and children (of male sex only) were recruited and followed up for 5 years. Phthalate metabolites during pregnancy were positively linked to BMI at 5 years and to weight increase from 2 to 5 years of age in children [126].…”

Section: Impact On Offspring: Short-term and Long-term Outcomesmentioning

confidence: 95%

Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications

et al. 2020

View full text Add to dashboard Cite

Endocrine-disrupting chemicals (EDCs) are exogenous substances that are able to interfere with hormone action, likely contributing to the development of several endocrine and metabolic diseases. Among them, Bisphenol A (BPA) and phthalates contaminate food and water and have been largely studied as obesogenic agents. They might contribute to weight gain, insulin resistance and pancreatic β-cell dysfunction in pregnancy, potentially playing a role in the development of pregnancy complications, such as gestational diabetes mellitus (GDM), and adverse outcomes. Pregnancy and childhood are sensitive windows of susceptibility, and, although with not univocal results, preclinical and clinical studies have suggested that exposure to BPA and phthalates at these stages of life might have an impact on the development of metabolic diseases even many years later. The molecular mechanisms underlying this association are largely unknown, but adipocyte and pancreatic β-cell dysfunction are suspected to be involved. Remarkably, transgenerational damage has been observed, which might be explained by epigenetic changes. Further research is needed to address knowledge gaps and to provide preventive measure to limit health risks connected with exposure to EDCs.

show abstract

Review of the Effects of Perinatal Exposure to Endocrine-Disrupting Chemicals in Animals and Humans

Nelson

Wang

Sakwari

et al. 2019

Reviews of Environmental Contamination and Toxicology

View full text Add to dashboard Cite

Phthalate pregnancy exposure and male offspring growth from the intra-uterine period to five years of age

Abstract: We highlighted associations between gestational exposure to some phthalates and growth in boys. The positive association between MEP and postnatal growth in boys was also reported in several previous human studies.

Cited by 78 publications

References 31 publications

Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity

Association of prenatal urinary phthalate metabolite concentrations and childhood BMI and obesity

Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications

Review of the Effects of Perinatal Exposure to Endocrine-Disrupting Chemicals in Animals and Humans

Contact Info

Product

Resources

About