Phototriggered Drug Delivery Using Inorganic Nanomaterials

Liu, Qian; Zhan, Changyou; Kohane, Daniel S.

doi:10.1021/acs.bioconjchem.6b00448

Cited by 58 publications

(31 citation statements)

References 91 publications

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“…The emission yield of these materials can be enhanced for potential applications in imaging, sensing, diagnosis, and therapy, but remains to be explored to its full extent . However, other nanostructures have been widely used for these applications, either due to their unique properties or due to their chemically controlled architectonics . GNRs can efficiently convert absorbed light into heat either through electron–electron interactions or electron–phonon interactions and have been established for their photothermal therapy (PTT) efficacy .…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8][9] However, other nanostructures have been widely used for these applications, either due to their uniquep roperties or due to their chemically controlled architectonics. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] GNRs can efficiently convert absorbed light into heat either through electron-electron interactions or electron-phonon interactions and have been established for their photothermal therapy (PTT) efficacy. [30,31] Furthermore, by incorporating ap hotosensitizer (PS) molecule, with ah igh singleto xygen yield, additional treatment modality,s uch as photodynamic therapy (PDT) could also be enabled in the same system, in addition to PTT.…”

Section: Introductionmentioning

confidence: 99%

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Luminescent Gold Nanorods To Enhance the Near‐Infrared Emission of a Photosensitizer for Targeted Cancer Imaging and Dual Therapy: Experimental and Theoretical Approach

Nair

Govindachar

et al. 2020

Chemistry A European J

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Strong plasmon absorption in the near‐infrared (NIR) region renders gold nanorods (GNRs) amenable for biomedical applications, particularly for photothermal therapy. However, these nanostructures have not been explored for their imaging potential because of their weak emission profile. In this study, the weak fluorescence emission of GNRs is tuned to match that of the absorption of a photosensitizer (PS) molecule, and energy transfer from the GNR to PS enhances the emission profile of the GNR–PS combination. GNR complexes generally quench the fluorescence emission of nearby chromophores. However, herein, the complex retains or rather enhances the fluorescence through competition in energy transfer. Excitation‐dependent energy transfer has been explained experimentally and theoretically by using DFT calculations, the CIE chromaticity diagram, and power spectrum. The final GNR–PS complex modified for tumor specificity serves as an excellent organ‐specific theranostic probe for bioimaging and dual therapy both in vitro and in vivo. Principal component analysis designates photodynamic therapy a better candidate than that of photothermal therapy for long‐term efficacy in vivo.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Luminescent Gold Nanorods To Enhance the Near‐Infrared Emission of a Photosensitizer for Targeted Cancer Imaging and Dual Therapy: Experimental and Theoretical Approach

Nair

Govindachar

et al. 2020

Chemistry A European J

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“…The recently emerged technologies of switching biochemical cascades via light promise effective delivery of signaling molecules in cells and in vivo to mediate a variety of crucial biological activities . Compared with other methods dependent on pH/temperature changes or enzyme concentration variations, the light‐triggered approach is featured with wavelength‐tunable performance and ultrahigh spatial resolution in practice . Activation of the caged molecules from their chemical progenitors must break covalent bonds typically, thus requiring sufficient energy input such as UV irradiation .…”

Section: Methodsmentioning

confidence: 99%

NIR‐Triggered Release of Nitric Oxide with Upconversion Nanoparticles Inhibits Platelet Aggregation in Blood Samples

Shen

Yang

et al. 2017

Part & Part Syst Charact

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There is a great challenge to overcome the limitation of tissue penetration depth, while maximizing the benefit of light‐triggered biochemical cascades in a well‐defined mode simultaneously. Here, a new method of near‐infrared (NIR) light‐triggered release of nitric oxide (NO) by developing upconversion nanoparticles (UCNPs)‐based conjugate chemistry is reported. As the key nanotransducer in the design, core–shell‐structured UCNPs are encapsulated with a layer of SiO2 and then covalently linked with a potent NO‐releasing donor (S‐nitroso‐N‐acetyl‐dl‐penicillamine, SNAP). It is featured with highly localized breakage of chemical bonds of SNAP molecules by NIR–UV upconversion, enabling simultaneous NO release in a light dosage‐dependent manner. The biological effects of NO releasing are demonstrated by cellular imaging and inhibition of platelet aggregation from blood samples. This work provides a flexible and robust platform to generate cell‐signaling gas molecules trigged by NIR laser with deep tissue penetration.

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“…Recently, application of photoactivation strategies has played an increasingly crucial role in the development of delivery systems. [11,13,[42][43][44][45][46] Considering their rapid growth and therapeutic relevance, it would be of significant value to evaluate their contributions made over recent 10 years. Here, this review article is therefore interested in compiling their specific examples and discussing their release mechanisms, design concepts, and practical impacts.…”

Section: Introductionmentioning

confidence: 99%

Photoactivation Strategies for Therapeutic Release in Nanodelivery Systems

Choi

2020

Advanced Therapeutics

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Control of therapeutic release constitutes one of most critical aspects considered in the design of nanoscale delivery systems. There are a variety of cellular factors and external stimuli employed for release control. Of these, use of light offers various photoactivation mechanisms that enable to effectively engage in therapeutic release. It also allows a higher degree of spatial and temporal control. Over recent decades, the application of photoactivation strategies has seen remarkable growth and made a significant impact on rapid advances in the field of drug delivery. This Review aims to summarize the fundamental concepts and practical applications demonstrated recently in numerous therapeutic areas from cancers to infectious diseases. Its scope is defined by a focus on those photoactivation strategies that occur via either linker cleavage, nanocontainer gating, or disassembly. Each of these is discussed with specific examples and underlying mechanisms that comprise linker photolysis, photoisomerization, photothermal heating, or photodynamic reactions with reactive oxygen species. In summary, this Review provides an inclusive summary of new developments and insights obtained from recent progress in photoactivation strategies and their applications in therapeutic nanodelivery.

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Phototriggered Drug Delivery Using Inorganic Nanomaterials

Cited by 58 publications

References 91 publications

Luminescent Gold Nanorods To Enhance the Near‐Infrared Emission of a Photosensitizer for Targeted Cancer Imaging and Dual Therapy: Experimental and Theoretical Approach

Luminescent Gold Nanorods To Enhance the Near‐Infrared Emission of a Photosensitizer for Targeted Cancer Imaging and Dual Therapy: Experimental and Theoretical Approach

NIR‐Triggered Release of Nitric Oxide with Upconversion Nanoparticles Inhibits Platelet Aggregation in Blood Samples

Photoactivation Strategies for Therapeutic Release in Nanodelivery Systems

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