Phototoxicity testing in guinea-pigs

Evaluation of skin phototoxicity study using SD rats by transdermal and oral administration

“…A previous report demonstrated that 8-MOP, acridin, and anthracene caused phototoxic reactions at concentrations of 0.003, 0.3 and 0.01 w/v%, respectively (Lovell and Sanders, 1992). However, during a preliminary study in our facility, 8-MOP did not cause a phototoxic reaction in guinea pigs at 0.003 w/v%, and therefore, higher concentrations of 0.2, 1 and 0.3 w/v% were used instead.…”

Evaluation of skin phototoxicity study using SD rats by transdermal and oral administration

“…A previous report demonstrated that 8-MOP, acridin, and anthracene caused phototoxic reactions at concentrations of 0.003, 0.3 and 0.01 w/v%, respectively (Lovell and Sanders, 1992). However, during a preliminary study in our facility, 8-MOP did not cause a phototoxic reaction in guinea pigs at 0.003 w/v%, and therefore, higher concentrations of 0.2, 1 and 0.3 w/v% were used instead.…”

Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients

“…However, where insufficient data exist the UV/VIS absorbance spectrum is evaluated to eliminate materials that have no significant absorbance in the range of 290-760nm. This is considered a valid screen because a photo-biological response is dependent on photo-activation of the test material and changes in absorbance following interaction with the skin are rare (Lovell, 1992). However, it has been debated as to what should be considered "no significant absorption".…”

Evaluation of the skin phototoxicity and photosensitivity of honeybee venom

“…Animal studies were approved by the Association for Assessment and Accreditation of Laboratory Animal Care International in Chemon Inc. Animals (5 per cage) were housed in aluminum cages (W9L9H: 49094709220 mm) in an animal room, which was controlled at a temperature of 23AE3°C, with a relative humidity of 55%AE15%, a 12-h light/dark cycle (lighting from 08:00 to 20:00 hours) and [10][11][12][13][14][15][16][17][18][19][20] ventilation changes/h. 14 The animals were allowed free access to a pellet diet (Cargill Agri Purina Inc., Seongnam, Korea), and drinking water was supplied by an automatic water supply system.…”

“…The average score was calculated by adding the scores for edema formation according to the primary skin irritation index as shown in Table 2. 16…”

Evaluation of skin phototoxicity study using SD rats by transdermal and oral administration

“…A previous report demonstrated that 8-MOP, acridin, and anthracene caused phototoxic reactions at concentrations of 0.003, 0.3 and 0.01 w/v%, respectively (Lovell and Sanders, 1992). However, during a preliminary study in our facility, 8-MOP did not cause a phototoxic reaction in guinea pigs at 0.003 w/v%, and therefore, higher concentrations of 0.2, 1 and 0.3 w/v% were used instead.…”

Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients

“…However, where insufficient data exist the UV/VIS absorbance spectrum is evaluated to eliminate materials that have no significant absorbance in the range of 290-760nm. This is considered a valid screen because a photo-biological response is dependent on photo-activation of the test material and changes in absorbance following interaction with the skin are rare (Lovell, 1992). However, it has been debated as to what should be considered "no significant absorption".…”

Evaluation of the skin phototoxicity and photosensitivity of honeybee venom

“…Animal studies were approved by the Association for Assessment and Accreditation of Laboratory Animal Care International in Chemon Inc. Animals (5 per cage) were housed in aluminum cages (W9L9H: 49094709220 mm) in an animal room, which was controlled at a temperature of 23AE3°C, with a relative humidity of 55%AE15%, a 12-h light/dark cycle (lighting from 08:00 to 20:00 hours) and [10][11][12][13][14][15][16][17][18][19][20] ventilation changes/h. 14 The animals were allowed free access to a pellet diet (Cargill Agri Purina Inc., Seongnam, Korea), and drinking water was supplied by an automatic water supply system.…”

“…The average score was calculated by adding the scores for edema formation according to the primary skin irritation index as shown in Table 2. 16…”

Evaluation of skin phototoxicity study using SD rats by transdermal and oral administration

“…A previous report demonstrated that 8-MOP, acridin, and anthracene caused phototoxic reactions at concentrations of 0.003, 0.3 and 0.01 w/v%, respectively (Lovell and Sanders, 1992). However, during a preliminary study in our facility, 8-MOP did not cause a phototoxic reaction in guinea pigs at 0.003 w/v%, and therefore, higher concentrations of 0.2, 1 and 0.3 w/v% were used instead.…”

Criteria for the Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients

“…However, where insufficient data exist the UV/VIS absorbance spectrum is evaluated to eliminate materials that have no significant absorbance in the range of 290-760nm. This is considered a valid screen because a photo-biological response is dependent on photo-activation of the test material and changes in absorbance following interaction with the skin are rare (Lovell, 1992). However, it has been debated as to what should be considered "no significant absorption".…”

Evaluation of the skin phototoxicity and photosensitivity of honeybee venom

“…Animal studies were approved by the Association for Assessment and Accreditation of Laboratory Animal Care International in Chemon Inc. Animals (5 per cage) were housed in aluminum cages (W9L9H: 49094709220 mm) in an animal room, which was controlled at a temperature of 23AE3°C, with a relative humidity of 55%AE15%, a 12-h light/dark cycle (lighting from 08:00 to 20:00 hours) and [10][11][12][13][14][15][16][17][18][19][20] ventilation changes/h. 14 The animals were allowed free access to a pellet diet (Cargill Agri Purina Inc., Seongnam, Korea), and drinking water was supplied by an automatic water supply system.…”

“…The average score was calculated by adding the scores for edema formation according to the primary skin irritation index as shown in Table 2. 16…”