Photothermal Therapy Nanomaterials Boosting Transformation of Fe(III) into Fe(II) in Tumor Cells for Highly Improving Chemodynamic Therapy

Abstract

Chemodynamic therapy based on Fe 2+ -catalyzed Fenton reaction holds great promise in cancer treatment. However, low-produced hydroxyl radicals in tumor cells constitute its severe challenges because of the fact that Fe 2+ with high catalytic activity could be easily oxidized into Fe 3+ with low catalytic activity, greatly lowering Fenton reaction efficacy. Here, we codeliver CuS with the iron-containing prodrug into tumor cells. In tumor cells, the overproduced esterase could cleave the phenolic ester bond in the prodrug to release Fe 2+ , activating Fenton reaction to produce the hydroxyl radical. Meanwhile, CuS could act as a nanocatalyst for continuously catalyzing the regeneration of high-active Fe 2+ from low-active Fe 3+ to produce enough hydroxyl radicals to efficiently kill tumor cells as well as a photothermal therapy agent for generating hyperthermia for thermal ablation of tumor cells upon NIR irradiation. The results have exhibited that the approach of photothermal therapy nanomaterials boosting transformation of Fe 3+ into Fe 2+ in tumor cells can highly improve Fenton reaction for efficient chemodynamic therapy. This strategy was demonstrated to have an excellent antitumor activity both in vitro and in vivo, which provides an innovative perspective to Fenton reaction-based chemodynamic therapy.

Recent Advances and Implication of Bioengineered Nanomaterials in Cancer Theranostics

“…BSA is used to regulate the size of MnS nanoparticles by tuning the ratio of BSA and Mn 2+ . Chemodynamic therapy (CDT) kills tumor cells by producing hydroxyl ions from H 2 O 2 at tumor sites [62]. It has been reported that Mn 2+ can be released by the MnO 2 shell on decomposition in the tumor microenvironment.…”

Rational design of nanomedicine for photothermal‐chemodynamic bimodal cancer therapy

“…Copyright 2019, WILEY‐VCH; Wang, An, Lin, et al (2020). Copyright 2020, Elsevier; Nie et al (2019). Copyright 2019, American Chemical Society)…”

“…Another strategy is to expand in terms of quantity and quality of catalytic ions harnessed for CDT in the nanomedicines. In the first instance, an ingenious nanodelivery system composed of CuS NPs, iron‐containing molecules and thermosensitive polymers was constructed (Nie et al, 2019). By irradiating NIR light, the resulting temperature enhancement due to CuS NPs achieved PTT ablation of tumors, and simultaneously triggered a phase change in thermosensitive polymers to release iron‐containing molecules.…”

Multishell Nanoparticles with “Linkage Mechanism” for Thermal Responsive Photodynamic and Gas Synergistic Therapy

“…As shown in Scheme 1, the template method is utilized to synthesize porous silica nanoparticles with CuS as core (CuS@SiO 2 ). [24][25][26][27] Water-soluble l-Arg is loaded within the cavity of SiO 2 . To solve the problem of premature releasing of l-Arg in the circulation, the PCM with wax-sealed profile are used to seal up the hole.…”