Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation

Liang, Xin; Ye, Xinyu; Wang, Chao; Xing, Chenyang; Miao, Qianwei; Xie, Zhongjian; Chen, Xiuli; Zhang, Xudong; Zhang, Han; Mei, Lin

doi:10.1016/j.jconrel.2019.01.027

Cited by 329 publications

(234 citation statements)

References 54 publications

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“…In the sense of application value, when bulk materials are transformed into corresponding 2D crystals, their properties will be greatly improved, and some new properties will be obtained, for example, quantum Hall effect, excellent optical properties, high specific surface area, ultrahigh carrier mobility at room temperature, and high thermal conductivity . Therefore, 2D crystals have attracted extensive attention of researchers in the fields of optoelectronic devices, energy materials, catalysts, and biomaterials, once graphene has been successfully prepared.…”

Section: Introductionmentioning

confidence: 99%

2D Crystal–Based Fibers: Status and Challenges

Meng

Kong

et al. 2019

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2D crystals are emerging new materials in multidisciplinary fields including condensed state physics, electronics, energy, environmental engineering, and biomedicine. To employ 2D crystals for practical applications, these nanoscale crystals need to be processed into macroscale materials, such as suspensions, fibers, films, and 3D macrostructures. Among these macromaterials, fibers are flexible, knittable, and easy to use, which can fully reflect the advantages of the structure and properties of 2D crystals. Therefore, the fabrication and application of 2D crystal–based fibers is of great importance for expanding the impact of 2D crystals. In this Review, 2D crystals that are successfully prepared are overviewed based on their composition of elements. Subsequently, methods for preparing 2D crystals, 2D crystals dispersions, and 2D crystal–based fibers are systematically introduced. Then, the applications of 2D crystal–based fibers, such as flexible electronic devices, high‐efficiency catalysis, and adsorption, are also discussed. Finally, the status‐of‐quo, perspectives, and future challenges of 2D crystal–based fibers are summarized. This Review provides directions and guidelines for developing new 2D crystal–based fibers and exploring their potentials in the fields of smart wearable devices.

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Section: Introductionmentioning

confidence: 99%

2D Crystal–Based Fibers: Status and Challenges

Meng

Kong

et al. 2019

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“…www.advmat.de www.advancedsciencenews.com Combination of immune stimulators and ICB is another widely used strategy to increase the anti-tumor effect, [152][153][154][155][156][157][158] as the presence of cancer-specific and active CTLs in the TME is a prerequisite of antitumor immunity. [100,120,159,160] To increase the intratumoral number of active CTLs, Gu's lab developed a DNA nano-cocoon (DNC) loaded with anti-PD-1 antibody (aPD-1) and CpG ODNs as adjuvant therapy after surgery.…”

Section: Designs Of Nanomedicines For Modulation Of Multiple Immune Cmentioning

confidence: 99%

Nanomedicine‐Based Immunotherapy for the Treatment of Cancer Metastasis

et al. 2019

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Metastasis is the leading cause of cancer‐associated death, with poor prognosis even after extensive treatment. The dormancy of metastatic cancer cells during dissemination or after colony formation is one major reason for treatment failure, as most drugs target cells of active proliferation. Immunotherapy has shown great potential in cancer therapy because the activity of effector cells is less affected by the metabolic status of cancer cells. In addition, metastatic cells out of immunosuppressive tumor microenvironment (TME) are more susceptible to immune clearance, although these cells can achieve immune surveillance evasion via strategies such as platelet and macrophage recruitment. Since nanomaterials themselves or their carried drugs have the capability to modulate the immune system, a great amount of focus has been placed on nanomedicine strategies that leverage immune cells participating the metastatic cascade. These nanomedicines successfully inhibit the tumor metastasis and prolong the survival of model animals. Immune cells that are involved in the metastasis cascade are first summarized and then recent and inspiring strategies and nanomaterials in this growing field are highlighted.

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“…[39,40] Compared to the traditional inorganic/organic nanoparticles, MOF offers adjustable structural and chemical composition at the molecular level together with tunable porosity and chemical stability, which can as transport vehicles for the delivery of imaging agents and biologically active molecules realize accurate diagnosis and treatment of tumors. [45] 2D nanosheets with large surface area, unique physical, and chemical properties have been widely used as theranostic agents for cancer treatment, such as graphene, transition metal dichalcogenides, black phosphorus, [46][47][48] boron nanosheets, [42] accomplishing multimodal imaging-guided synergistic treatment. [43] Porphyrin-based MOF that have been developed so far for potential PDT outcome, however, almost all of them are compounded with other nanoparticles to form new compounds for synergistic treatment (such as PDT-PTT, PDT-Radiation therapy), [44] the complex structures would reduce the clinical medical value.…”

Section: Doi: 101002/advs201900530mentioning

confidence: 99%

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

et al. 2019

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Hypoxic tumor microenvironment is the bottleneck of the conventional photodynamic therapy (PDT) and significantly weakens the overall therapeutic efficiency. Herein, versatile metal–organic framework (MOF) nanosheets (DBBC‐UiO) comprised of bacteriochlorin ligand and Hf 6 (µ 3 ‐O) 4 (µ 3 ‐OH) 4 clusters to address this tricky issue are designed. The resulting DBBC‐UiO enables numerous superoxide anion radical (O 2 −• ) generation via a type I mechanism with a 750 nm NIR‐laser irradiation, part of which transforms to high toxic hydroxyl radical (OH•) and oxygen (O 2 ) through superoxide dismutase (SOD)‐mediated catalytic reactions under severe hypoxic microenvironment (2% O 2 ), and the partial recycled O 2 enhances O 2 −• generation. Owing to the synergistic radicals, it realizes advanced antitumor performance with 91% cell mortality against cancer cells in vitro, and highly efficient hypoxic solid tumor ablation in vivo. It also accomplishes photoacoustic imaging (PAI) for cancer diagnosis. This DBBC‐UiO, taking advantage of superb penetration depth of the 750 nm laser and distinct antihypoxia activities, offers new opportunities for PDT against clinically hypoxic cancer.

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Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation

Cited by 329 publications

References 54 publications

2D Crystal–Based Fibers: Status and Challenges

2D Crystal–Based Fibers: Status and Challenges

Nanomedicine‐Based Immunotherapy for the Treatment of Cancer Metastasis

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

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