Phototherapy induced cutaneous eruption in a neonate with transient porphyrinemia

Abstract

While this is an uncommon occurrence, transient porphyrinemia should be considered in neonates with phototherapy induced cutaneous eruption and erythroblastosis fetalis.

Phototherapy‐induced blistering reaction and eruptive melanocytic nevi in a child with transient neonatal porphyrinemia

“…or resulted in localized atrophy, scarring or milia. [2][3][4][5][6] We found no clue to the etiology of transient porphyrinemia in the present patient. The acute phototoxic reaction was similar to those reported previously, but the eruption of melanocytic nevi 3 months after the blistering reaction is unique.…”

“…Transient porphyrinemia in newborns seems to be rare, the present being the tenth case reported . All cases were detected because of adverse reactions to phototherapy.…”

“…Porphyrin levels had returned to normal by the age of 4 to 5 months in all of the infants reported. The acute cutaneous symptoms resolved spontaneously without any permanent sequelae, or resulted in localized atrophy, scarring or milia …”

Widespread eruption after blood transfusion during phototherapy in a newborn

“…2 Although purpura generally occurs in patients with infection, thrombocytopenia, or coagulation disorders, these diagnoses were excluded for the present case with clinical and laboratory findings. 4 Our patient's elevated urinary porphyrin levels supported the diagnosis of PIPE. PIPE can be observed extremely rarely in newborns with hemolytic disease of the newborn (HDN) receiving exchange transfusion and phototherapy.…”

Transient dermatoses: Leaving a lasting memory

“…24 It is hypothesized that transiently elevated porphyrin levels in the skin absorb visible light during exposure to phototherapy, leading to the development of a photo-induced cutaneous eruption. 25 11. Vesiculopustular eruption in transient myeloproliferative disorder of Down syndrome: A characteristic vesiculopustular eruption occurs in neonates with trisomy 21 or mosaicism for trisomy 21.…”