1989
DOI: 10.1001/archderm.125.6.783
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Photosensitizing potential of certain nonsteroidal anti-inflammatory agents

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Cited by 13 publications
(9 citation statements)
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“…The phototoxicity of a wide range of NSAIDs has also been assessed in healthy subjects, who had received nabumetone, naproxen, ketoprofen and piroxicam, and the skin response to radiation was compared with that observed in placebo-treated subjects [11]. Only nabumetone and naproxen were shown to induce any phototoxicity, which in all cases was mild and occurred at the end of the dosing period, immediately after irradiation.…”
Section: Discussionmentioning
confidence: 99%
“…The phototoxicity of a wide range of NSAIDs has also been assessed in healthy subjects, who had received nabumetone, naproxen, ketoprofen and piroxicam, and the skin response to radiation was compared with that observed in placebo-treated subjects [11]. Only nabumetone and naproxen were shown to induce any phototoxicity, which in all cases was mild and occurred at the end of the dosing period, immediately after irradiation.…”
Section: Discussionmentioning
confidence: 99%
“…However, in vitro and in vivo studies have not shown that piroxicam has phototoxic potential (Serrano et al 1984;Kaidbey and Mitchell 1989). Though the possibility of a photoallergic mechanism seems more likely, this interval between treatment start and photoreaction is shorter than can be accepted if the reaction represented a primary photoallergic sensitization to piroxicam.…”
Section: Discussionmentioning
confidence: 99%
“…The mechanism of the reaction pattern, either photoallergy or phototoxicity, is not established [4][5][6][7]. Rashes are usu ally vesiculobullous, but they may be maculopapular.…”
Section: Discussionmentioning
confidence: 99%
“…Sev eral cutaneous reactions are induced by these drugs, espe cially those related to sun exposure [3,4], Piroxicam is a new anti-inflammatory drug, and an increasing number of adverse reactions to sunlight is observed [5][6][7],…”
Section: Introductionmentioning
confidence: 99%