Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy

Lin, Jing; Wang, Shouju; Huang, Peng; Wang, Zhe; Chen, Shouhui; Niu, Gang; Li, Wanwan; He, Jie; Cui, Daxiang; Lu, Guangming; Chen, Xiaoyuan; Nie, Zhihong

doi:10.1021/nn4011686

Cited by 606 publications

(552 citation statements)

References 45 publications

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“…3 GNP properties are convenient for biomedical applications, such as drug and gene delivery, 4,5 DNA detection, 6 bioimaging, [7][8][9] and photothermal therapy of cancers. 10,11 GNP safety data derived from studies on tissue cultures may not reflect the real picture in vivo. 12 Available in vivo data are contradictory.…”

Section: Introductionmentioning

confidence: 99%

Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters

Saleh¹,

Soliman²,

El-Shazly³

et al. 2016

IJN

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In vivo responses to gold nanoparticles (GNPs) vary not only according to the size, shape, surface charge, and capping agent of GNPs but also according to the animal model, the route of administration, and the exposure frequency and duration. We illustrate here the changes in some hematologic parameters, in the hepatic and renal functions, and in the histopathology of solid organs after multiple intraperitoneal injections of 18 nm GNPs in adult male Syrian golden hamsters. We scored the histopathological changes in the liver and kidneys to grade the deleterious effects. Multiple intraperitoneal injections of 18 nm GNPs in hamsters were nonlethal in the short term but resulted in macrocytosis and hypochromasia, leukocytosis, neutrophilia, lymphocytosis, and monocytosis. The hepatic and renal functions showed nonsignificant changes; however, histopathological examination showed hepatic and renal alterations ranging from mild to marked degeneration, with occasional necrosis of hepatocytes and tubular epithelium.

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Section: Introductionmentioning

confidence: 99%

Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters

Saleh¹,

Soliman²,

El-Shazly³

et al. 2016

IJN

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“…The heating e®ect releases the encapsulated Ce6 molecules from fabricated AuNPs and signi¯-cantly increases the accumulation of Ce6 and assembled AuNPs in cancer cells for visualizing tumor tissues through thermal,°uorescence and PA signals separately. 36 It is a typical strategy and potential medical model using the optical properties of AuNPs for cancer theranostics.…”

Section: Aunps-based Tumor Contrast Imaging In Vivomentioning

confidence: 99%

Gold nanoparticles for cancer theranostics — A brief update

Zhao

Pan

Cheng

et al. 2016

J. Innov. Opt. Health Sci.

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Gold nanoparticles (AuNPs) exhibit superior optical and physical properties for more e®ective treatment of cancer through incorporating both diagnostic and therapeutic functions into one single platform. The ability to passively accumulate on tumor cells provides AuNPs the opportunity to become an attractive contrast agent for X-ray based computed tomography (CT) imaging in vivo. Because of facile surface modi¯cation, various size and shape of AuNPs have been extensively functionalized and applied as active nanoprobes and drug carriers for cancer targeted theranostics. Moreover, their capabilities on producing photoacoustic (PA) signals and photothermal e®ects have been used to image and treat tumor progression, respectively. Herein, we review the developments of AuNPs as cancer diagnostics and chemotherapeutic drug vector, summarizing strategies for tumor targeting and their applications in vitro and in vivo.

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“…Therefore, it is essential the improvement and the development of techniques to obtain porphyrin forming supramolecular structures 25 . On this sense, several kinds of techniques such as micelles 26 , vesicles 27 , Langmuir-Blodgett (LB) films 28,29 , Langmuir-Schaefer (LS) films 3,4 and Layerby-Layer films 30,31 have been applied and optimized. Among them, LB and LS techniques represent widely employed deposition methods to fabricate porphyrin thin films in a controlled way onto solid substrates 25,32 .…”

Section: Introductionmentioning

confidence: 99%

Supramolecular arrangements of an organometallic forming nanostructured films

et al. 2014

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Drganometallic materials have become subject of intensive research on distinct technological applications. The Langmuir-Blodgett (LB) and Langmuir-Schaefer (LS) techniques have proven to be suitable to address challenges inherent to organic devices, in which the film properties can be tuned at molecular level. Here, we report on the supramolecular arrangement of zinc(OO)-protoporphyrin(OX) dimethyl ester (ZnPPOX-DME) using the Langmuir, LB and LS techniques, leading to nanostructured films. The π-A isotherms showed that π-π stacking interaction among ZnPPOX-DME molecules takes place at the air/water interface, favoring the formation of Langmuir films closely packed. The controlled growth of the LB and LS films was monitored via UV-Vis absorption spectroscopy, with the thickness per monolayer within 1.3 and 1.7 nm. The homogeneous topography found at microscale is no longer preserved at nanoscale, which is found rougher according to AFM data. The FTOR indicated that the ZnPPOX-DME is isotropically arranged on both LB and LS films.

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Photosensitizer-Loaded Gold Vesicles with Strong Plasmonic Coupling Effect for Imaging-Guided Photothermal/Photodynamic Therapy

Cited by 606 publications

References 45 publications

Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters

Acute hematologic, hepatologic, and nephrologic changes after intraperitoneal injections of 18 nm gold nanoparticles in hamsters

Gold nanoparticles for cancer theranostics — A brief update

Supramolecular arrangements of an organometallic forming nanostructured films

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