Photoprotection of ultraviolet-B filters: Updated review of endocrine disrupting properties

Lorigo, Margarida; Mariana, Melissa; Cairrão, Elisa

doi:10.1016/j.steroids.2018.01.006

Cited by 48 publications

(24 citation statements)

References 97 publications

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“…Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter [13]. This substance is suspected to be an EDC [14,15] due to its demonstrated interaction with oestrogen, androgen, progesterone and thyroid receptors [16]. Studies on the toxicity of this UV-B filter were focused primarily on animal models and demonstrated multiple hormonal activities: oestrogenic [14,15,17,18,19,20,21,22,23], antiandrogenic [24,25,26], antiprogestenic [17,25] and antithyroid [19,25,27,28,29].…”

Section: Introductionmentioning

confidence: 99%

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UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries

Lorigo

Quintaneiro

Lemos

et al. 2019

IJMS

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Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca2+ channels (L-Type VOCC).

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Section: Introductionmentioning

confidence: 99%

“…This issue is of special importance because, as a UV-B filter, OMC can bioaccumulate in the aquatic ecosystems [30,31] and has greater environmental repercussions with potential risks to human health [16,32]. For instance, recently the US state of Hawaii has banned sunscreens containing OMC due the potential risks posed to corals [33].…”

Section: Introductionmentioning

confidence: 99%

UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries

Lorigo

Quintaneiro

Lemos

et al. 2019

IJMS

Self Cite

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“…Octylmethoxycinnamate (OMC) is the world's most widely used UV-B filter. OMC is present in more than 90% of personal care products (PCPs), including sunscreens (Zucchi et al 2011), and is listed as an endocrine disruptor compound (EDC) by the European Union's database (Lorigo et al 2018;Sharma et al 2017). This UV-B filter is an organic filter once its protective effects occur by absorbing high-energy photons of UV-B radiation (Burnett et al 2012;Mancebo et al 2014).…”

Section: Uv-b Filter Octylmethoxycinnamate Photoinstabilitymentioning

confidence: 99%

“…However, these photobiologic effects in humans are mainly due to UV-B radiation (Lopes and McMahon 2016;Nunes et al 2018). For this reason, the use of UV filters in sunscreens has increased in the last decade as a photoprotection strategy (Krause et al 2012;Lorigo et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Antioxidants as stabilizers of UV filters: an example for the UV-B filter octylmethoxycinnamate

Lorigo

2019

biomed dermatol

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Background: Sunlight is one of the main harmful exogenous factors that induce the reactive oxygen species formation. The human skin is the first line of photoprotection against harmful exogenous factors, such as UV radiations. The topical application of sunscreens, containing UV-B filters, is widely used to protect against UV-induced damage. Octylmethoxycinnamate is the world's most widely used UV-B filter in sunscreens. However, recent studies have demonstrated that this substance is an endocrine disruptor compound and with potential to damage DNA. Thus, the safety of this organic filter is a current concern for human health, and it was urgent to develop new photoprotective strategies. In this sense, due to the potential to neutralize the UV-induced free radicals, the use of antioxidants as UV filter stabilizers presented as a novel promising strategy. Research: The purpose of this review was to assess the use of antioxidants as stabilizers for UV-B filter octylmethoxycinnamate. For this, we discuss the chemical and physical characteristics of UV-B filter octylmethoxycinnamate, emphasizing the stability, photostability, and reactivity of this UV filter. The use of antioxidants in sunscreens will also be addressed, from a perspective of the main characteristics that allowed their use in sunscreen formulations. Then, the concomitant use of both was described from a historical and physical chemical perspective, always emphasizing the advantages and disadvantages of this association. Conclusions: The combination of antioxidants with UV-B filter octylmethoxycinnamate in appropriated formulations represents a viable strategy to protect the human skin against UV-induced damage.

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“…Its application has proven to be effective in preventing sunburns; however, studies have shown that it behaves like an endocrine disruptor. [76] Other UVB filters commonly used are Octocrylene and Ensulizole.…”

Section: Measures For Skin Cancer Preventionmentioning

confidence: 99%

Photochemistry of 1,3-Dicarbonyl Compounds: DNA Photodamage vs. Photoprotection

Espert¹,

Isabel²

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Photoprotection of ultraviolet-B filters: Updated review of endocrine disrupting properties

Cited by 48 publications

References 97 publications

UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries

UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries

Antioxidants as stabilizers of UV filters: an example for the UV-B filter octylmethoxycinnamate

Photochemistry of 1,3-Dicarbonyl Compounds: DNA Photodamage vs. Photoprotection

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