Photoprotection assessment of olive (Olea europaea L.) leaves extract standardized to oleuropein: In vitro and in silico approach for improved sunscreens

Silva, Anne C.P. da; Paiva, Juliana P.; Diniz, Raiane R.; Anjos, Vitor M. dos; Silva, Ana Beatriz S.M.; Pinto, Alicia Viviana; Santos, Elisabete Pereira dos; Leitão, Álvaro C.; Cabral, Lúcio Mendes; Rodrigues, Carlos Rangel; Pádula, Marcelo de; Santos, Bianca Aloise Maneira Corrêa

doi:10.1016/j.jphotobiol.2019.03.003

Cited by 49 publications

(36 citation statements)

References 81 publications

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“…The potential of olive leaves for the prevention of many human diseases such as hypertension, cardiovascular, and diabetes, has been performed (Orak, Karamac, & Amarowicz, 2019). Recently, the photoprotective potential of olive leaves extract has been also evaluated (da Silva et al., 2019), whereas only minor studies report the bioactivities of the two varieties of leaves of Olea europaea sampled in genotypes grown Tunisia (Khlif et al., 2015). To the best of our knowledge, no data are available regarding the cytotoxicity and the allelopathic activities of these varieties.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profile, cytotoxic, antioxidant, and allelopathic potentials of aqueous leaf extracts of Olea europaea

Zaïri

Nouir

Zarrouk

et al. 2020

Food Science & Nutrition

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Although bioactivities of Olea europaea (OE) have been widely described, most of them were related to its methanolic extracts or its essential oils, While data related to aqueous extracts still very scarce. Thus, in this study, the phytochemical composition, the antioxidant activity, the cytotoxic potential, and the allelopathic potential of aqueous leaf extracts from two varieties of Olea europaea were investigated and compared. High‐performance liquid chromatography (HPLC) was used to identify and quantify the constituents of the tested plants, and spectrophotometric methods to evaluate antioxidant activities. The cytotoxic potential was investigated using murine oligodendrocytes (158N) while germination seeds’ test was used for allelopathic activity. HPLC analysis showed the presence of 10 phenolic compounds in both extracts. Chemlali variety showed the highest antioxidant and allelopathic activities. Regarding the cytotoxicity effect, a significant increase in cell viability was observed with both of our extracts compared to untreated cells. These results confirm that aqueous extracts from OE produce a range of substances with potential antioxidant, antifungal, and allelopathic effects without toxic effects. Thus, they could be used as an alternative of chemical compounds.

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Section: Introductionmentioning

confidence: 99%

Phytochemical profile, cytotoxic, antioxidant, and allelopathic potentials of aqueous leaf extracts of Olea europaea

Zaïri

Nouir

Zarrouk

et al. 2020

Food Science & Nutrition

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“…In previous work, chemical filters were found to be fundamental in anti-UVB protection; nevertheless, the addition of pomace meaningfully improved the performance of this factor because of the synergism of phenolics from grape pomace and sun filters [16]. In another study, the Olea europaea [52] and Moringa oleifera Lam. leaf extracts [53] also improved sunscreens by synergism [52].…”

Section: Discussionmentioning

confidence: 93%

Safety and Photoprotective Efficacy of a Sunscreen System Based on Grape Pomace (Vitis vinifera L.) Phenolics from Winemaking

et al. 2020

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In winemaking, a large amount of grape pomace is produced that is rich in polyphenolics and highly beneficial for human health, as phenols are useful for skin ultraviolet (UV) protection. In this investigation, we evaluated the safety and clinical efficacy of a sunscreen system containing a grape pomace extract from Vitis vinifera L. as a bioactive ingredient. The recovery of phenolics in the waste was performed by percolation. Nine emulsions were developed using a factorial design and two were evaluated clinically: Formulation E, containing only UV filters (butylmethoxydibenzoyl methane, ethylhexyl methoxycinnamate and ethylhexyl dimethyl PABA), and F, with the extract at 10.0% w/w + UV filters. The antioxidant activity was determined by the DPPH assay and the in vitro efficacy was established by sun protection factor (SPF) measurements (Labsphere UV-2000S). Clinical tests were performed to determine safety (human repeated insult patch test) and to confirm efficacy (photoprotective effectiveness in participants). The results showed a synergistic effect between the sunscreen system and the extract on UVB protection and antioxidant activity. Both samples were considered safe. Formulation F was 20.59% more efficient in protecting skin against UVB radiation, taking approximately 21% more time to induce erythema compared to the extract-free sample.

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“…Considering that sunscreen formulations available on the market have similar SPF values; e.g., SPF 15 and 30, this result could be promising and possibly even improved by the addition of other phytochemicals or synthetic photoprotector substances (Matsui et Rodriguésia 71: e00672019. 2020 Silva et al 2019). Antioxidant activity of Piper umbellata L. was reported by Baldoqui et al (2009), and was attributed to the presence of 4-nerolidylcathecol, which exhibits antioxidant activity as potent as that of alpha-tocopherol.…”

Section: Phytochemicals In Photoprotectionmentioning

confidence: 97%

Can natural products improve skin photoprotection?

et al. 2020

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Due to increased UV radiation on the Earth’s surface, caused by depletion of the stratospheric ozone, people have become more susceptible to different types of skin damage, such as erythema, sunburns, and cancer; this is especially of concern in tropical countries. Thus, efforts to improve awareness as well as the use of sunscreen are increasing worldwide. However, synthetic UV filters have been associated with deleterious effects such as photosensitization. Natural products have been used by ancient cultures for several purposes, including protecting the skin from the sun. However, there is still doubt today whether photoprotection is a real phenomenom or whether it is simply tanning of the skin. Plants have self-protective mechanisms and produce secondary metabolites that can protect themselves from UV radiation. Yet, can phytochemical compounds protect human skin? This review discusses the paradoxical effect of chemical UV filters and the influence of phytochemicals in in vitro and in vivo tests of photoprotection.

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Photoprotection assessment of olive (Olea europaea L.) leaves extract standardized to oleuropein: In vitro and in silico approach for improved sunscreens

Cited by 49 publications

References 81 publications

Phytochemical profile, cytotoxic, antioxidant, and allelopathic potentials of aqueous leaf extracts of Olea europaea

Phytochemical profile, cytotoxic, antioxidant, and allelopathic potentials of aqueous leaf extracts of Olea europaea

Safety and Photoprotective Efficacy of a Sunscreen System Based on Grape Pomace (Vitis vinifera L.) Phenolics from Winemaking

Can natural products improve skin photoprotection?

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