Photopolymerized silk fibroin gel for advanced burn wound care

Indrakumar, Sushma; Joshi, Akshat; Dash, Tapan K.; Mishra, Vivek; Tandon, Bharat; Chatterjee, Kaushik

doi:10.1016/j.ijbiomac.2023.123569

Cited by 14 publications

(20 citation statements)

References 65 publications

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“…SF-based dressings have also proven their efficacy as carriers for the local delivery of drugs, bioactive agents, and growth factors while supporting complete healing. 23,24,26 As of today, collagen is the most popular biopolymer used in wound dressings; some examples are Integra (Integra Life-Sciences), Biobrane (Smith & Nephew), Kollagen (Eucare), etc. Collagen-based commercial dressings promote tissue growth and facilitate collagen deposition within the wound bed.…”

Section: Silk Fibroin For Wound Care Applicationsmentioning

confidence: 99%

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Silk Fibroin and Its Nanocomposites for Wound Care: A Comprehensive Review

Indrakumar,

Dash,

Mishra

et al. 2024

ACS Polym. Au

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For most individuals, wound healing is a highly organized, straightforward process, wherein the body transitions through different phases in a timely manner. However, there are instances where external intervention becomes necessary to support and facilitate different phases of the body's innate healing mechanism. Furthermore, in developing countries, the cost of the intervention significantly impacts access to treatment options as affordability becomes a determining factor. This is particularly true in cases of long-term wound treatment and management, such as chronic wounds and infections. Silk fibroin (SF) and its nanocomposites have emerged as promising biomaterials with potent wound-healing activity. Driven by this motivation, this Review presents a critical overview of the recent advancements in different aspects of wound care using SF and SF-based nanocomposites. In this context, we explore various formats of hemostats and assess their suitability for different bleeding situations. The subsequent sections discuss the primary causes of nonhealing wounds, i.e., prolonged inflammation and infections. Herein, different treatment strategies to achieve immunomodulatory and antibacterial properties in a wound dressing were reviewed. Despite exhibiting excellent pro-healing properties, few silk-based products reach the market. This Review concludes by highlighting the bottlenecks in translating silk-based products into the market and the prospects for the future.

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Section: Silk Fibroin For Wound Care Applicationsmentioning

confidence: 99%

“…Among them, silk fibroin (SF) has emerged as a potential candidate for wound dressings. SF-based dressings have also proven their efficacy as carriers for the local delivery of drugs, bioactive agents, and growth factors while supporting complete healing. ,, …”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin and Its Nanocomposites for Wound Care: A Comprehensive Review

Indrakumar,

Dash,

Mishra

et al. 2024

ACS Polym. Au

Self Cite

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“…238 The photooxidation of tyrosine in silk fibroin was used to fabricate drug-loaded hydrogel dressing for advanced burn wound care. 239…”

Section: Protein-derived Photopolymersmentioning

confidence: 99%

“…The hydrogel constructs printed with silk sericin constructs showed reversible shrinkage and expansion, or a shape memory effect, while the mechanical properties of silk fibroin-based constructs can be tuned by changing the concentration . The photooxidation of tyrosine in silk fibroin was used to fabricate drug-loaded hydrogel dressing for advanced burn wound care …”

Section: Protein-derived Photopolymersmentioning

confidence: 99%

Renewable Photopolymers: Transformation of Biomass Resources into Value-Added Products Under Light

Lai,

Zhang,

Xiao

2023

ACS Sustainable Chem. Eng.

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Light-induced cross-linking of liquid monomers has found widespread applications in various fields, such as dentistry, coatings, tissue engineering, and 3D printing. These processes typically rely on monomers derived from petrochemicals, which are volatile in price and are becoming increasingly depleted, compelling researchers to explore alternative sources from forestry and agricultural crops. The renewability of these resources makes them a promising option for developing substitutive materials with similar or superior properties. The various structural subunits in biomass offer alternative building blocks for petroleum-based photopolymers including the double bond-containing and hydrophobic fatty acids and terpenes, hydrophilic carbohydrates and proteins, aromatic furfural compounds from carbohydrates, and phenolic moieties in lignin. They can be transformed into photopolymers by the inherent or chemically introduced photocurable bonds. This review seeks to highlight recent advancements in transforming renewable platform chemicals into photocurable systems for photopolymerization processes and examines the thermomechanical properties and applications of the resulting cured materials. Furthermore, potential issues for improvement are also identified, such as the cost-effectiveness of biomass-based photopolymers and the risk in competition with food production. The perspectives on future directions for improving the renewability in this area are also given.

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“…Another key concern in this field is using far UV light for photopolymerization and the resultant genetic and phenotypic changes. This limitation has motivated research to develop PIs that are responsive to visible − or near-infrared radiation , (NIR).…”

Section: Photopolymerizable Bioink Componentsmentioning

confidence: 99%

Trends in Photopolymerizable Bioinks for 3D Bioprinting of Tumor Models

Gugulothu,

Asthana,

Homer-Vanniasinkam

et al. 2023

JACS Au

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Three-dimensional (3D) bioprinting technologies involving photopolymerizable bioinks (PBs) have attracted enormous attention in recent times owing to their ability to recreate complex structures with high resolution, mechanical stability, and favorable printing conditions that are suited for encapsulating cells. 3D bioprinted tissue constructs involving PBs can offer better insights into the tumor microenvironment and offer platforms for drug screening to advance cancer research. These bioinks enable the incorporation of physiologically relevant cell densities, tissue-mimetic stiffness, and vascularized channels and biochemical gradients in the 3D tumor models, unlike conventional two-dimensional (2D) cultures or other 3D scaffold fabrication technologies. In this perspective, we present the emerging techniques of 3D bioprinting using PBs in the context of cancer research, with a specific focus on the efforts to recapitulate the complexity of the tumor microenvironment. We describe printing approaches and various PB formulations compatible with these techniques along with recent attempts to bioprint 3D tumor models for studying migration and metastasis, cell–cell interactions, cell–extracellular matrix interactions, and drug screening relevant to cancer. We discuss the limitations and identify unexplored opportunities in this field for clinical and commercial translation of these emerging technologies.

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Photopolymerized silk fibroin gel for advanced burn wound care

Cited by 14 publications

References 65 publications

Silk Fibroin and Its Nanocomposites for Wound Care: A Comprehensive Review

Silk Fibroin and Its Nanocomposites for Wound Care: A Comprehensive Review

Renewable Photopolymers: Transformation of Biomass Resources into Value-Added Products Under Light

Trends in Photopolymerizable Bioinks for 3D Bioprinting of Tumor Models

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