Photophysical and photochemical properties of the pharmaceutical compound salbutamol in aqueous solutions

Dodson, Leah G.; Vogt, R.; Marks, Joyann; Reichardt, Christian; Crespo‐Hernández, Carlos E.

doi:10.1016/j.chemosphere.2011.01.048

Cited by 27 publications

(20 citation statements)

References 73 publications

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“…So far, the removal methods of salbutamol have been focused on oxidation [12,13] and photodegradation [14][15][16][17][18][19] techniques. Despite being effective in degrading contaminants, oxidation processes typically generate intermediates and oxidation products whose stability and toxicity can be higher than that of the micropollutant itself [15].…”

Section: Figurementioning

confidence: 99%

Rapid uptake of pharmaceutical salbutamol from aqueous solutions with anionic cellulose nanofibrils: The importance of pH and colloidal stability in the interaction with ionizable pollutants

Selkälä

Sirviö

Suopajärvi

et al. 2018

Chemical Engineering Journal

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Micropollutants escaping conventional wastewater treatment processes pose a threat to biota and the environment. Amongst micropollutants, small and ionizable organic compounds are particularly challenging, since their removal depends significantly on prevailing conditions.In this study, anionic cellulose nanofibrils (CNFs) were shown to perform as promising adsorbents for an ionizable pharmaceutical, salbutamol. The adsorbents were produced from wood cellulose through succinylation pretreatment in urea-LiCl deep eutectic solvent (DES), followed by a nanofibrillation procedure. The impact of pH, contact time, salbutamol 2 concentration, and adsorbent dose on salbutamol uptake were investigated in batch adsorption studies. Based on the results, the chemical modification of cellulose significantly enhanced the adsorption of salbutamol. The adsorption efficiency was mainly dependent on the charge and colloidal stability of the anionic nanofibril suspension rather than the charge of salbutamol, because the adsorption was considerably improved at pH>7 due to the deprotonation of the cellulose carboxyl groups. The experimental maximum adsorption capacity was 196 mg/g. This study highlights the potential of cellulose nanomaterial adsorbents and the importance of controlling the charge of the adsorbent material when developing solutions for ionizable micropollutant removal.

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Section: Figurementioning

confidence: 99%

Rapid uptake of pharmaceutical salbutamol from aqueous solutions with anionic cellulose nanofibrils: The importance of pH and colloidal stability in the interaction with ionizable pollutants

Selkälä

Sirviö

Suopajärvi

et al. 2018

Chemical Engineering Journal

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“…Potassium ferrioxalate was used as an actinometer to measure the lamp intensity in photons/s [50]. Photodegradation yields were measured using the method recently developed by Dodson et al [51] under O 2 -and airsaturated conditions.…”

Section: Steady-state Measurementsmentioning

confidence: 99%

On the Primary Reaction Pathways in the Photochemistry of Nitro-Polycyclic Aromatic Hydrocarbons

Crespo‐Hernández¹

2013

Mod Chem Appl

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The primary reaction pathways in the photochemistry of nitro-polycyclic aromatic hydrocarbons under specific laboratory conditions are briefly summarized. In addition, photochemical data is presented for 2-nitronaphthalene, 1-nitronaphthalene, and 2-methyl-1-nitronaphthalene in cyclohexane and acetonitrile solutions under aerobic and anaerobic conditions. It is shown that molecular oxygen significantly reduces the photodegradation quantum yield of 1-nitronaphthalene and 2-methyl-1-nitronaphthalene by 63% and 81%, respectively, whereas 2-nitronaphthalene is photoinert in both solvents under aerobic and anaerobic conditions. In addition, it is proposed that recombination of the aryl and nitrogen (IV) dioxide geminate radical pair within the solvent cage or internal conversion of an initially formed intramolecular charge transfer state may play an important role in the fraction of excited molecules that returns to the ground state in 1-nitronaphthalene and 2-methyl-1-nitronaphthalene. Scavenging of radical species by molecular oxygen and the generation of singlet oxygen in high yield are proposed to contribute to the photochemistry of these nitro-naphthalene derivatives in solution.

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“…Previous studies have also observed the fluorescence of solution phase SS. 18,19 The pMDI generated particles show two distinct spectra which are dependent upon RH. At RH below B92% the spectra are nearidentical to the bulk crystalline material, confirming that the particles generated by the pMDI are largely crystalline in composition as they exit the pMDI.…”

mentioning

confidence: 99%

Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI)

et al. 2014

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Photophysical and photochemical properties of the pharmaceutical compound salbutamol in aqueous solutions

Cited by 27 publications

References 73 publications

Rapid uptake of pharmaceutical salbutamol from aqueous solutions with anionic cellulose nanofibrils: The importance of pH and colloidal stability in the interaction with ionizable pollutants

Rapid uptake of pharmaceutical salbutamol from aqueous solutions with anionic cellulose nanofibrils: The importance of pH and colloidal stability in the interaction with ionizable pollutants

On the Primary Reaction Pathways in the Photochemistry of Nitro-Polycyclic Aromatic Hydrocarbons

Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI)

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