Photodynamic treatment of oral lichen planus

Kvaal, Sigrid I.; Angell-Petersen, Even; Warloe, Trond

doi:10.1016/j.oooo.2012.08.448

Cited by 50 publications

(30 citation statements)

References 46 publications

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“…Also, a low HAL concentration has been shown to result in a relatively higher fluorescence level shortly after application compared with ALA . By monitoring the superficial fluorescence in every patient receiving PDT, we confirmed the induction and bleaching of PpIX in a standardized way (data not shown), as found in other studies . The mechanism of action of PDT in GELP and oral lichen planus is unknown but is thought to be linked to an effect on T lymphocytes …”

Section: Discussionsupporting

confidence: 87%

“…Interestingly, the effect of HAL‐PDT seems to be maintained for several months, as patient‐reported use of topical corticosteroids in weeks 7–24 was significantly lower in the PDT group than in the corticosteroid group. Similar prolonged effect of MAL‐PDT has been reported in oral lichen planus …”

Section: Discussionsupporting

confidence: 82%

“…Our group has previously shown that PDT may be effective in oral erosive lichen planus . In a microscopic fluorescence photometry study, we demonstrated photoactive protoporphyrin IX (PpIX) in both mucosal epithelium and submucosal tissue with high inflammatory activity in GELP lesions after topical application of HAL gel .…”

mentioning

confidence: 92%

“…Topical photodynamic therapy (PDT) is a well‐established treatment for actinic keratosis and superficial basal cell carcinoma, using several photosensitizers, such as aminolevulinic acid (ALA), methyl 5‐aminolevulinate (MAL) and hexyl 5‐aminolevulinate hydrochloride (HAL). There are some reports on ALA‐ and MAL‐based PDT in nonmalignant inflammatory mucosal diseases, such as genital lichen sclerosus and oral lichen planus . Also, ALA‐PDT and HAL‐PDT have been tried in vulval intraepithelial neoplasia and cervical carcinoma in situ , respectively.…”

mentioning

confidence: 99%

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Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial

et al. 2015

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 82%

mentioning

confidence: 92%

mentioning

confidence: 99%

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Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial

et al. 2015

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“…Algumas terapias alternativas para LO como a terapia fotodinâmica (PDT), que consiste associação de um fotossensibilizante como o ácido 5-aminolevulínico (ALA) e o laser de baixa potência (LLLT), tem mostrado resultados benéficos nos casos de LO e leucoplasias verrucosas proliferativas (Kvaal;Warloe, 2007 (Holpuch et al, 2011).…”

Section: Tratamentounclassified

Análise comparativa da expressão imuno-histoquímica da via PI3K-AKT-mTOR em displasias epiteliais, lesões irritativas e carcinomas espinocelulares

Martins¹

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Clinical information regarding sex, age of the patient and location of the lesions were compiled. The slides (HE staining) were observed by two pathologists and all cases were re-evaluated under light microscope. The proteins investigated were: pAKT, pmTOR, PS6, and p4EBP1. The staining pattern of the antibodies was quantified by acquiring images using a photomicroscope. In the captured image (400x magnification), the total of counted labeled cells, were divided by the total number of cells present in the field captured. The staining pattern was classified into positive and negative and also divided into degrees starting from "0" to "3". The study variables were evaluated by chi-square test, ANOVA F and univariate logistic regression analysis. Among all the cases of MN, positivity was found only for pS6(50% of cases); in FH cases immunoreactivity was observed in pS6 (54.8% of cases) and 4EBP1 (22.6% of cases). In LRD immunoreactivity was observed in pS6 (67.4% of cases), pAKT (56.2% of cases), p4EBP1 (41.7% of cases) and pmTOR (29.2% of cases), while for HRD cases positivity was found for pS6 (74% of cases), pAKT (68% of cases), p4EBP1 (44% of cases) and pmTOR (28% of cases). In SCCs cases positivity was found for pAKT (83.3% of cases), PS6 (77.4% of cases), p4EBP1 (50% of cases) and pmTOR (50% of cases). Statistically significant differences were observed in all positive study groups for the proteins pAKT, pmTOR and p4EBP.After the evaluation of SCC and the oral dysplasia groups, there were statistically significant differences for the study groups that showed imunorretivity for the proteins pAKT and pmTOR. Therefore, we conclude that all the proteins of the study are good biomarkers to differentiate normal tissue from OD and SCC, but only pAKT and pmTOR proteins could be related to carcinogenesis.

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Emerging potential of phototherapy in management of symptomatic oral lichen planus: A systematic review of randomised controlled clinical trials

Hanna

Dalvi²,

Tomov

et al. 2023

Journal of Biophotonics

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Photodynamic treatment of oral lichen planus

Cited by 50 publications

References 46 publications

Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial

Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial

Análise comparativa da expressão imuno-histoquímica da via PI3K-AKT-mTOR em displasias epiteliais, lesões irritativas e carcinomas espinocelulares

Emerging potential of phototherapy in management of symptomatic oral lichen planus: A systematic review of randomised controlled clinical trials

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