1995
DOI: 10.1001/archderm.131.6.737
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Photodynamic therapy of nonmelanoma skin cancer with topical aminolevulinic acid: a clinical and histologic study

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Cited by 65 publications
(45 citation statements)
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“…There were 14 small prospective studies (comprising 297 patients) which evaluated the response of SCCs to photodynamic therapy [619][620][621][622][623][624][625][626][627][628][629][630][631][632] (see Appendix 13). Three studies separated SCCs according to level or depth of invasion 619,622,625 and one was a non-randomised two-arm comparison of topical photodynamic therapy either with or without a 5% glycolic acid penetration enhancer.…”
Section: Photodynamic Therapymentioning
confidence: 99%
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“…There were 14 small prospective studies (comprising 297 patients) which evaluated the response of SCCs to photodynamic therapy [619][620][621][622][623][624][625][626][627][628][629][630][631][632] (see Appendix 13). Three studies separated SCCs according to level or depth of invasion 619,622,625 and one was a non-randomised two-arm comparison of topical photodynamic therapy either with or without a 5% glycolic acid penetration enhancer.…”
Section: Photodynamic Therapymentioning
confidence: 99%
“…Five studies specified that histological assessment of at least some of the treated areas was done to confirm apparent clinical response. 620,622,629,631,632 In eight of the included studies, SCCs that had apparently completely responded to photodynamic therapy initially were observed for recurrence. [621][622][623]625,[629][630][631][632] Pooled recurrence data from these studies (119 SCCs) gave an odds of recurrence of 26.4% (95% CI 12.3% to 43.7%; I 2 = 72%) ( Figure 48).…”
Section: Photodynamic Therapymentioning
confidence: 99%
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“…This result draws attention to the insufficient penetration of topical ALA in the profound dermis. In one study, although 69% of the topically ALA-treated tumors, including BCC, SCC in situ and invasive SCC were clinically cured, only 46% of the treated tumors were histologically negative, emphasizing the possibility of recurrence (Lui et al, 1995). Improvements regarding this issue can be obtained through the curettage of the tumors right before the application of ALA or through pretreatment with dimethylsulfoxide (DMSO) or by increasing the incubation time of ALA to 48 hours or through intralesional injections with ALA.…”
Section: Basal Cell Carcinomamentioning
confidence: 99%
“…Die Anforderung an eine Lichtquelle bei der PDT bestehen in der Verfügbarkeit ausreichender Lichtmengen, ho− mogene Verteilung im Zielareal und eine ausreichende Eindring− tiefe, die im Wesentlichen von der Wellenlänge des emittierten [29]. Auch Lui et al [30] fanden bei der komplet− ten Exzision von 2 ± 3 Monate zuvor bestrahlten oberflächlichen Basaliomen zwar eine klinische Ansprechrate von 69 %, bei der histologischen Aufarbeitung zeigte sich jedoch nur eine Gesamt− ansprechrate von 46 %. Zudem wiesen die Autoren in Überein− stimmung mit Cairnduff et al [31], der nach einer Beobachtungs− zeit von 17 Monaten ebenfalls mit ALA−PDT bei superfiziellen Ba− saliomen eine komplette Remission in 50 % der Fälle erzielte, auf das Problem der möglicherweise zu kurzen Nachbeobachtungs− zeit bei der Evaluierung des Stellenwertes der PDT hin.…”
Section: Lichtquellenunclassified