Photodynamic therapy in dermatology. Shedding a different light on skin disease

Lui, H.

doi:10.1001/archderm.128.12.1631

Cited by 23 publications

(12 citation statements)

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“…Photodynamic therapy was confirmed by the Food and Drug Administration in 1999 to treat pre-cancerous skin lesions in the head and face. 7 The Mechanism of Action of Photodynamic Therapy PDT comprise the application of visible light, combined with a photosensitizer (PS) and with the oxygen ( Figure 1). 8 PDT is based on the interplay of visible light and a photosensitizer agent which under photo-activation generate short lived cytotoxic species in site.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy: An Effective Alternative Approach to Control Bacterial Infections

et al. 2018

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Introduction: The purpose of this review was to evaluate the available literature for in vitro and in vivo effectiveness of antimicrobial Photodynamic therapy (aPDT) in the field of bacteriology. Methods: A review of the relevant articles carried out in PubMed and Scopus to determine the efficiency of aPDT used in the reduction of microbial infection. Thirty-one relevant documents retrieved from PubMed, Scopus by inserting "antimicrobial photodynamic therapy" and "bacterial infection" and "photodynamic therapy" keywords. Results: According to different results, aPDT can be used as an adjuvant for the treatment of infectious diseases. The use of photosensitizer methylene blue, toluidine blue O (TBO), indocyanine green with light diode laser centered at (630±10 nm) and (650±10 nm) wavelengths have been shown to have significant results for the treatment of infectious diseases and bactericidal properties Conclusion: These findings suggest that, aPDT can be an efficient method in the treatment of localized and superficial infections.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy: An Effective Alternative Approach to Control Bacterial Infections

et al. 2018

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“…Recently, PDT also has been used to eliminate tumor cells. 8,9 To have a specific toxic effect on bacterial cells, the respective photosensitizer needs to have a selectivity for prokaryotic cells. Although several authors have reported the possibility of a lethal photosensitization of bacteria in vivo and in vitro, [10][11][12][13] others have pointed out that Gram-negative bacterial species, due to their special cell wall, are largely resistant to PDT.…”

mentioning

confidence: 99%

Killing of Periodontopathogenic Bacteria by Photodynamic Therapy

Pfitzner

Sigusch

Albrecht

et al. 2004

Journal of Periodontology

146

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“…The application of PDT has been used in the treatment of cancerous skin lesions and cancerous tumors of the head, neck, lung, and esophagus. 40 The concept of PDT to treat nonhealing chronic wounds and eradicate bacterial biofilms has gained much attention. 41 Interestingly, an in vitro study by Kömerik et al demonstrated the effectiveness of PDT against P. aeruginosa proteases, whereby there was a significant reduction in P. aeruginosa proteases following exposure to red light in the presence of toluidine blue.…”

Section: Bacterial Proteases As Diagnostic Markers In Chronic Woundsmentioning

confidence: 99%

Extracellular Bacterial Proteases in Chronic Wounds: A Potential Therapeutic Target?

Suleman

2016

Advances in Wound Care

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Significance: Bacterial biofilms are considered to be responsible for over 80% of persistent infections, including chronic lung infections, osteomyelitis, periodontitis, endocarditis, and chronic wounds. Over 60% of chronic wounds are colonized with bacteria that reside within a biofilm. The exaggerated proteolytic environment of chronic wounds, more specifically elevated matrix metalloproteinases, is thought to be one of the possible reasons as to why chronic wounds fail to heal. However, the role of bacterial proteases within chronic wounds is not fully understood. Recent Advances: Recent research has shown that bacterial proteases can enable colonization and facilitate bacterial immune evasion. The inhibition of bacterial proteases such as Pseudomonas aeruginosa elastase B (LasB) has resulted in the disruption of the bacterial biofilm in vitro. P. aeruginosa is thought to be a key pathogen in chronic wound infection, and therefore, the disruption of these biofilms, potentially through the targeting of P. aeruginosa bacterial proteases, is an attractive therapeutic endeavor. Critical Issues: Disrupting biofilm formation through the inhibition of bacterial proteases may lead to the dissemination of bacteria from the biofilm, allowing planktonic cells to colonize new sites within the wound. Future Directions: Despite a plethora of evidence supporting the role of bacterial proteases as virulence factors in infection, there remains a distinct lack of research into the effect of bacterial proteases in chronic wounds. To assess the viability of targeting bacterial proteases, future research should aim to understand the role of these proteases in a variety of chronic wound subtypes.

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Photodynamic therapy in dermatology. Shedding a different light on skin disease

Cited by 23 publications

References 0 publications

Antimicrobial Photodynamic Therapy: An Effective Alternative Approach to Control Bacterial Infections

Antimicrobial Photodynamic Therapy: An Effective Alternative Approach to Control Bacterial Infections

Killing of Periodontopathogenic Bacteria by Photodynamic Therapy

Extracellular Bacterial Proteases in Chronic Wounds: A Potential Therapeutic Target?

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