Photodynamic therapy-improved oncolytic bacterial immunotherapy with FAP-encoding S. typhimurium

Guo, Yanxia; Song, Mo; Liu, Xiaoqing; Chen, Yu; Xun, Zhen; Sun, Yujie; Tan, Wenzhi; He, Jianjun; Zheng, Jin

doi:10.1016/j.jconrel.2022.09.050

Cited by 13 publications

(7 citation statements)

References 53 publications

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“… 84 Currently, PDT has been employed in the treatment of solid tumors and exhibited remarkable efficacy in eradicating tumor cells. For instance, Guo et al 85 have proposed the utilization of PDT-enhanced oncolytic bacterial immunotherapy (OBI) through the use of genetically modified S. typhimurium which express a fluorogen-activating protein (FAP). Upon stimulation of FAP, it leads to the generation of fluorescence and ROS so as to resulting in the killing of cancer cells and over-accumulated bacteria.…”

Section: Outline Of the Mechanisms Of Engineered Bacteria Targeting T...mentioning

confidence: 99%

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Wang,

Sun,

Hua

et al. 2024

Int J Oral Sci

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Despite decades of research, cancer continues to be a major global health concern. The human mouth appears to be a multiplicity of local environments communicating with other organs and causing diseases via microbes. Nowadays, the role of oral microbes in the development and progression of cancer has received increasing scrutiny. At the same time, bioengineering technology and nanotechnology is growing rapidly, in which the physiological activities of natural bacteria are modified to improve the therapeutic efficiency of cancers. These engineered bacteria were transformed to achieve directed genetic reprogramming, selective functional reorganization and precise control. In contrast to endotoxins produced by typical genetically modified bacteria, oral flora exhibits favorable biosafety characteristics. To outline the current cognitions upon oral microbes, engineered microbes and human cancers, related literatures were searched and reviewed based on the PubMed database. We focused on a number of oral microbes and related mechanisms associated with the tumor microenvironment, which involve in cancer occurrence and development. Whether engineering oral bacteria can be a possible application of cancer therapy is worth consideration. A deeper understanding of the relationship between engineered oral bacteria and cancer therapy may enhance our knowledge of tumor pathogenesis thus providing new insights and strategies for cancer prevention and treatment.

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Section: Outline Of the Mechanisms Of Engineered Bacteria Targeting T...mentioning

confidence: 99%

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Wang,

Sun,

Hua

et al. 2024

Int J Oral Sci

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“…1). 63 As a result, photodynamic therapy could generate ROS to kill cancer cells along with the over-accumulated bacteria. The released molecular patterns associated with pathogens and damaged cells could recruit and activate immune cells such as macrophages, neutrophils, and dendritic cells.…”

Section: Geb and Cancer Therapymentioning

confidence: 99%

“…Such combined therapy shows great potential in cancer immunotherapy. 63 In another study, Salmonella has been genetically engineered by modifying the length of their LPS to facilitate the exhibition of the RGD4C targeting peptide on the exterior membrane surface of the bacteria. This investigation has revealed that the tumor-targeting attenuated Salmonella strain can administer endostatin and TRAIL concurrently, two factors with distinct anti-tumor properties, and is able to impede tumor progression and increase the animals’ survival rate significantly.…”

Section: Geb and Cancer Therapymentioning

confidence: 99%

Genetically engineered bacteria: a new frontier in targeted drug delivery

Fooladi,

Rabiee,

Iravani

2023

J. Mater. Chem. B

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“…Owing to the weakened immune system, bacteria-mediated tumor therapy is ineffective in patients who have undergone chemotherapy [118] and can cause serious infections. Moreover, bacterial monotherapy does not completely cure cancer, and bacterium-mediated synergistic cancer therapy was proposed to have promising potential [119,120]. Further studies are warranted to understand the interactions between oncolytic immunotherapies and other therapies.…”

Section: Oral Microbes and Cancer Treatmentmentioning

confidence: 99%

Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma

Wang,

Gao

2023

Current Oncology

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Microorganisms in the oral cavity are abundant in the human body. At present, more than 700 species of oral microorganisms have been identified. Recently, a lot of literature has indicated that the oral microbiota plays an important role in the occurrence, development, and prognosis of oral squamous cell carcinoma (OSCC) through various mechanisms. And researchers are now trying to utilize oral microbiota in cancer diagnosis and treatment. However, few articles systematically summarize the effects of oral microbes in the diagnosis, treatment, and disease outcomes of oral cancer. Herein, we made a summary of the microbial changes at cancerous sites and placed more emphasis on the mechanisms by which the oral microbiome promotes cancerization. Moreover, we aimed to find out the clinical value of the oral microbiome in OSCC.

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Photodynamic therapy-improved oncolytic bacterial immunotherapy with FAP-encoding S. typhimurium

Cited by 13 publications

References 53 publications

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Promising dawn in tumor microenvironment therapy: engineering oral bacteria

Genetically engineered bacteria: a new frontier in targeted drug delivery

Mechanisms and Potential Clinical Implications of Oral Microbiome in Oral Squamous Cell Carcinoma

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