Photodynamic and photothermal tumor therapy using phase-change material nanoparticles containing chlorin e6 and nanodiamonds

Ryu, Taekyung; Baek, Seung-Moon; Kang, Rae Hyung; Jeong, Kyu Shik; Jun, Dae-Ryong; Choi, Sung‐Wook

doi:10.1016/j.jconrel.2017.12.008

Cited by 48 publications

(19 citation statements)

References 42 publications

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“…The detection of these ROS intermediates and others such as singlet oxygen has been previously reported for other carbon‐based nanosystems . The generation of superoxide anions ( .…”

Section: Resultsmentioning

confidence: 85%

“…The detection of these ROS intermediates and otherss uch as singlet oxygen [19] has been previously reported for other carbon-based nanosystems. [14,[20][21][22][61][62][63][64][65][66][67][68] The generation of superoxide anions( CO 2 À )i sa ssisted by the electron donor character of the N-CNDs, which are able to reduce the intracellular O 2 present in the cells [21,69] (Figure 3b and Figure S4 in the Supporting Information). Given the high reactivity of this radical, it will rapidly lead to as eries of cascade reactions involving the generation of non-radical ROS such as H 2 O 2 (Figure 3a and Figure S4 in the Supporting Information) either through the formation of peroxide intermediates [21] or with the assistance of superoxide dismutases (SOD)a ctivated as ROS scavengers by cells [60] ( Figure S4 in the SupportingI nformation).…”

Section: Synthesis and Characterization Of Edta-derived Carbon Nanodotsmentioning

confidence: 99%

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Upconverting Carbon Nanodots from Ethylenediaminetetraacetic Acid (EDTA) as Near‐Infrared Activated Phototheranostic Agents

Ortega‐Liebana

Encabo‐Berzosa

Casanova

et al. 2019

Chemistry A European J

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This work describes the synthesis of nitrogendoped carbon nanodots (CNDs) synthesized from ethylenediaminetetraacetic acid (EDTA) as aprecursor and their application as luminescent agentsw ith ad ual-mode theranostic role as near-infrared (NIR)t riggered imaging and photodynamic therapy agents.I nterestingly,t hese fluorescent CNDs are more rapidlya nd selectively internalized by tumorc ells and exhibit very limited cytotoxicity until remotelya ctivated with aN IR illumination source. These CNDsa re excellent candidates forp hototheranostic purposes, for example, si-multaneousi maging and therapy can be carriedo ut on cancer cells by using their luminescent properties and the in situ generation of reactive oxidative species(ROS) upon excitation in the NIR range. In the presence of CNDs,N IR remote activation induces the in vitro killing of U251MG cells. Through the use of flow imaging cytometry,w eh ave been able to successfully mapa nd quantify the different types of cell deaths induced by the presence of intracellular superoxide anions (CO 2 À )a nd hydrogen peroxide (H 2 O 2 )R OS generated in situ upon NIR irradiation. [a] Dr.M.C.O rtega-Liebana, Dr.M.M.Encabo-Berzosa,D r.Supporting information and the ORCID identification number(s) for the author(s) of this articlecan be found under: https://doi.

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“…The detection of these ROS intermediates and others such as singlet oxygen has been previously reported for other carbon‐based nanosystems . The generation of superoxide anions ( .…”

Section: Resultsmentioning

confidence: 85%

Section: Synthesis and Characterization Of Edta-derived Carbon Nanodotsmentioning

confidence: 99%

Upconverting Carbon Nanodots from Ethylenediaminetetraacetic Acid (EDTA) as Near‐Infrared Activated Phototheranostic Agents

Ortega‐Liebana

Encabo‐Berzosa

Casanova

et al. 2019

Chemistry A European J

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“…Critical for effective dosing of deep‐seated tumors due to the exponential attenuation of light, the activation threshold for the photothermal effect was at least ten times lower compared to other nanodiamond‐based systems . The endocytic transport behavior and the immediate cellular response toward localized heating, observed in confocal and time‐lapsed microscopy, clearly demonstrate the efficiency of the system.…”

Section: Resultsmentioning

confidence: 91%

Transferrin‐Coated Nanodiamond–Drug Conjugates for Milliwatt Photothermal Applications

Harvey

Raabe

Ermakova

et al. 2019

Advanced Therapeutics

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Fluorescent nanodiamonds (fNDs) are unique carbon-based nanomaterials due to their outstanding optical and magnetic properties. However, realization of the full potential of fNDs is often limited by their processability because fNDs aggregate strongly in both organic and aqueous solutions. Therefore, robust and potentially universal coating strategies are urgently needed to address these limitations. Derived from mussel foot proteins, the polymerization of l-3,4-dihydroxyphenylalanine (l-DOPA) provides important surface functional groups including amines, carboxylic acid, alcohols, and conjugated Michael acceptors. Herein, l-DOPA is polymerized on fNDs with a high control over the shell thickness. Photoluminescence and optically detected magnetic resonance studies reveal that the unique photophysical properties of fNDs are preserved after thin poly(l-DOPA) film coating. Subsequently, conjugation of transferrin, a heme protein that provides efficient receptor-specific cellular transport, improves the colloidal stability and cellular uptake of the poly(l-DOPA)-coated fNDs. The loading of FDA-approved indocyanine green as a photothermal agent yields an integrated biohybrid material exhibiting an amplified photothermal effect in cells at very low energy intake (≈90 mW cm −2 ).

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“…Owing to these excellent properties of strong absorption and favorable light and thermal stability, DND has been widely utilized for photothermal therapy by generating hyperthermia under illumination to kill tumor cells. 27,28 Moreover, beneting from their plentiful chemically active carboxyl-, hydroxyl-, carbonyl-, nitrogen-, and sulfur-groups around the outer surface of DND substances, 29 DND also has acted as a functional ller in the production of composites. [30][31][32] In a few words, the mutually benecial characteristics suggest that DND can be easily encapsulated into hydrogels, and thereby impart excellent photothermal performance to a hydrogel, consequently realizing sunlight-controlled water releaser property.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of detonation nanodiamond@sodium alginate hydrogel beads and their performance in sunlight-triggered water release

Zheng

Bai

et al. 2019

RSC Adv.

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Photodynamic and photothermal tumor therapy using phase-change material nanoparticles containing chlorin e6 and nanodiamonds

Cited by 48 publications

References 42 publications

Upconverting Carbon Nanodots from Ethylenediaminetetraacetic Acid (EDTA) as Near‐Infrared Activated Phototheranostic Agents

Upconverting Carbon Nanodots from Ethylenediaminetetraacetic Acid (EDTA) as Near‐Infrared Activated Phototheranostic Agents

Transferrin‐Coated Nanodiamond–Drug Conjugates for Milliwatt Photothermal Applications

Fabrication of detonation nanodiamond@sodium alginate hydrogel beads and their performance in sunlight-triggered water release

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