Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid

Maiz–Fernández, Sheila; Pérez‐Álvarez, Leyre; Silván, Unai; Vilas-Vilela, José Luis; Lanceros‐Méndez, S.

doi:10.1016/j.ijbiomac.2022.07.004

Cited by 40 publications

(20 citation statements)

References 41 publications

(55 reference statements)

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“…Moreover, CTS-based hydrogels strongly depend on the processing conditions (pH, gelation temperature, concentration) [ 98 ]. Thus, CTS has been thoroughly studied for hydrogel manufacture, due to its structure, versatility and properties, such as good biocompatibility (>80%) [ 104 ], biodegradability, low toxicity and mucoadhesiveness, in addition to its anti-inflammatory, antibacterial, antifungal and wound-healing abilities [ 187 ]. Moreover, in vivo experiment results confirm the ability of CTS-based hydrogels to accelerate tissue regeneration to reduce inflammation and facilitate wound healing [ 102 , 103 ].…”

Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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Section: Methodsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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“…Multi-polysaccharide materials obtained with the participation of chitosan are a common practice [ 164 , 165 , 166 ]. An interesting procedure was described by Gilarska et al [ 167 ], which concerned the combination of chitosan, hyaluronic acid, and collagen for the production of an injectable hydrogel.…”

Section: Complexed Delivery Systemsmentioning

confidence: 99%

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

Kurczewska

2022

Polymers

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Polysaccharides constitute one of the most important families of biopolymers. Natural polysaccharide-based drug delivery systems are of constant interest to the scientific community due to their unique properties: biocompatibility, non-toxicity, biodegradability, and high availability. These promising biomaterials protect sensitive active agents and provide their controlled release in targeted sites. The application of natural polysaccharides as drug delivery systems is also intensively developed by Polish scientists. The present review focuses on case studies from the last few years authored or co-authored by research centers in Poland. A particular emphasis was placed on the diversity of the formulations in terms of the active substance carried, the drug delivery route, the composition of the material, and its preparation method.

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“…There are also studies into the material modification to confer the photo-crosslinking capacity to hydrogels by grafting photo-initiating groups for printability improvement. For instance, hyaluronic acid (HA), another widely used bioink for bioprinting, provides an ECM-like microenvironment [ 75 ], and its photo-crosslinkable derivatives, HAMA [ [76] , [77] , [78] ], improves the vulnerable soft texture and slow crosslinking of the bioink. Similar cases include methacryloyl-alginate [ 79 , 80 ] (AlgMA), chitosan methacrylate [ 81 ] (CSMA), etc.…”

Section: Introductionmentioning

confidence: 99%

In vivo bioprinting: Broadening the therapeutic horizon for tissue injuries

Zhao

2023

Bioactive Materials

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Photocrosslinkable and self-healable hydrogels of chitosan and hyaluronic acid

Cited by 40 publications

References 41 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Recent Reports on Polysaccharide-Based Materials for Drug Delivery

In vivo bioprinting: Broadening the therapeutic horizon for tissue injuries

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