2009
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Abstract: The effect of an azobenzene-based photoresponsive surfactant on fibril formation of beta-amyloid (1-40) (Abeta40) has been studied using small-angle neutron scattering (SANS), atomic force microscopy (AFM), and light scattering (LS) measurements. Fibril formation is inhibited with a lag phase persisting for approximately 5 h in the presence of the trans isomer of the photosurfactant under visible light (i.e., the relatively hydrophobic, activated form). Conversely, only a 2-h lag phase is observed under UV lig… Show more

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Cited by 19 publications
(22 citation statements)
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References 75 publications
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“…Hydrophobically driven assemblies, once initiated, are difficult to reverse. [45] The coupling reaction between the lysine amines on the surfaces of the nanofibrils and the vinyl groups on the micelle corona then essentially locked in and stabilized the respective assembled structures.…”
Section: Resultsmentioning
confidence: 99%
“…Hydrophobically driven assemblies, once initiated, are difficult to reverse. [45] The coupling reaction between the lysine amines on the surfaces of the nanofibrils and the vinyl groups on the micelle corona then essentially locked in and stabilized the respective assembled structures.…”
Section: Resultsmentioning
confidence: 99%
“…468 A cationic surfactant containing an azobenzene moiety influences A 40 fibrillization differently depending on its conformation, which can be photo-switched. 470 The interaction of A (12-28)…”
Section: Micellesmentioning
confidence: 99%
“…[16] Finally, after 30 h of incubation, the morphology of hIAPPmembrane systems, which consist of rows of cylinders with long-range order in the XY plain, appears to be very similar to the one observed for Ab 1-40 fibrils. [22] A possible mechanism for membrane damage and fibril growth by hIAPP based on our AFM, QCM-D and fluorescence results combined with NMR spectroscopy [23] is shown in Figure 4. From this model emerges a scenario in which the formation of mature fibrils does not appear to be the cause of membrane damage.…”
mentioning
confidence: 92%