Photochemotherapy of vitiligo. Use of orally administered psoralens and a high-intensity long-wave ultraviolet light system

Abstract

A new light source that provides high-intensity ultraviolet light (UVA) (300 to 400 nm) to the entire body surface makes orally administered psoralen treatment of vitilligo with an artificial light practical. In the 26 patients studied, the degree of repigmentation with either trioxsalen (TMP) or methoxsalen (8-MOP) and high intensity UVA was at least as great as that with the same oral agents and sunlight. With artificial UVA and similar treatment conditions, the two psoralen derivatives were compared in the treatment of vitiligo; TMP stimulated repigmentation as well as 8-MOP and caused fewer side effects.

Response of vitiligo to PUVA therapy in Saudi patients

“…The trunk, face, arms, and legs were sensitive to therapy while the periorficial and acral areas where resistant to therapy; an observation that is consistent with previous reports. Previous studies have shown that age, sex, age of onset of disease, duration of disease, and extent of involvement do not influence the outcome of vitiligo therapy with PUVA 1–9,12 . In this study the only factors to affect the overall response rate with statistical significance were the surface areas of involvement and the total sessions to induce pigmentation (p‐value < 0.05).…”

“…Previous studies have shown that age, sex, age of onset of disease, duration of disease, and extent of involvement do not influence the outcome of vitiligo therapy with PUVA. [1][2][3][4][5][6][7][8][9]12 In this study the only factors to affect the overall response rate with statistical significance were the surface areas of involvement and the total sessions to induce pigmentation (p-value < 0.05). Our data showed that age, age of disease onset, and duration of disease do not affect the outcome of PUVA therapy.…”

A non-inferiority randomized controlled clinical trial comparing Unani formulation & psoralen plus ultraviolet A sol in chronic plaque psoriasis

“…Gahalaut et al 11 and Aggarwal et al 8 reported that 60-70 per cent of their patients on PUVA developed side effects with more than half of these being nausea and vomiting. Parrish et al 19 and Singh et al 6 also reported 23 and 55.6 per cent of their patients on PUVA, respectively, complained of nausea and vomiting. However, Handa et al 20 in a retrospective analysis observed that only 3.5 per cent of their patients on photochemotherapy with psoralens in vitiligo had developed nausea and vomiting.…”

Strategy for Multifunctional Hollow Shelled Triple Oxide Mn–Cu–Al Nanocomposite Synthesis via Microwave-Assisted Technique

“…This is because the intensity of UV rays from sunlight is less when compared to the intensity of UV light used for degradation purposes. 34 Thus, MnO 2 is very active in UV light since the band gap is 3.4 eV. For other catalysts, sunlight seems better because it provides a broad range of energy.…”

“…Except the catalyst SM, all other catalysts work better in sunlight when compared to UV light. This is because the intensity of UV rays from sunlight is less when compared to the intensity of UV light used for degradation purposes . Thus, MnO 2 is very active in UV light since the band gap is 3.4 eV.…”