1976
DOI: 10.1001/archderm.112.7.943
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Photochemotherapy for psoriasis with orally administered methoxsalen

Abstract: Photochemotherapy denotes a therapeutic approach that is based on the interaction of light and a photoactive drug. This study describes the efficacy of photochemotherapy, using orally administered methoxsalen and long-wave ultraviolet light in 91 patients with severe, generalized psoriasis. Oral administration of methoxsalen was followed by exposure to a high-intensity long-wave ultraviolet light source, emitting a continuous spectrum between 320 and 390 nm (peak, 365 nm) and an energy of 5.6 to 7.5 mw/sq cm a… Show more

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Cited by 81 publications
(13 citation statements)
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“…An emission spectrum in the visible and UV wavelength range was obtained with a spectroradiometer (Spectro-Systems Ltd). The irradiance was measured with a Waldmann PUVA meter as used in dosimetry for the UV-A photochemotherapy of psoriasis (Wolff et al, 1976;Diffey, Challoner & Kay, 1980;Kenicer et al, 1981). This instrument had been calibrated indirectly against a standardised linear thermophile (Rank-Hilger, and was used to determine the total UV-A output of the fluorescent tubes of the sun-bed.…”
Section: Methodsmentioning
confidence: 99%
“…An emission spectrum in the visible and UV wavelength range was obtained with a spectroradiometer (Spectro-Systems Ltd). The irradiance was measured with a Waldmann PUVA meter as used in dosimetry for the UV-A photochemotherapy of psoriasis (Wolff et al, 1976;Diffey, Challoner & Kay, 1980;Kenicer et al, 1981). This instrument had been calibrated indirectly against a standardised linear thermophile (Rank-Hilger, and was used to determine the total UV-A output of the fluorescent tubes of the sun-bed.…”
Section: Methodsmentioning
confidence: 99%
“…2 In the 1950s, Dr. John Ingram developed a treatment regimen using ultraviolet B (UVB) radiation in conjunction with coal tar and anthralin paste. 3 In the 1970s, broadband UVB was discovered to be effective in clearing mild forms of psoriasis when given in doses, 4 while ultraviolet A (UVA) irradiation in combination with either oral 5, 6 or topical application 7 of psoralen, was found to be effective in treating psoriasis. In the 1980s, a more defined wavelength of UVB was discovered by researchers to be particularly effective in treating psoriasis—and was subsequently referred to as narrowband UVB (nbUVB).…”
Section: Introductionmentioning
confidence: 99%
“…RAL 8-methoxypsoralen photochemotherapy (8-MOP psoralen-UV-A [PUVA]) is a well-established and effective treatment for psoriasis. [1][2][3][4][5] The main concern with PUVA is the risk of nonmelanoma skin cancers [6][7][8] and more recently the risk of melanoma. 9 The action spectra of phototherapy for psoriasis 10,11 led to the development by Philips (Eindhoven, the Netherlands) of a fluorescent lamp emitting narrowband UV-B between 311 and 313 nm, referred to as the TL-01 lamp.…”
mentioning
confidence: 99%