Photochemical Synthesis and Versatile Functionalization Method of a Robust Porous Poly(ethylene glycol methacrylate-co-allyl methacrylate) Monolith Dedicated to Radiochemical Separation in a Centrifugal Microfluidic Platform

Abstract

Abstract:The use of a centrifugal microfluidic platform is an alternative to classical chromatographic procedures for radiochemistry. An ion-exchange support with respect to the in situ light-addressable process of elaboration is specifically designed to be incorporated as a radiochemical sample preparation module in centrifugal microsystem devices. This paper presents a systematic study of the synthesis of the polymeric porous monolith poly(ethylene glycol methacrylate-co-allyl methacrylate) used as a solid-phase support and the versatile and robust photografting process of the monolith based on thiol-ene click chemistry. The polymerization reaction is investigated, varying the formulation of the polymerisable mixture. The robustness of the stationary phase was tested in concentrated nitric acid. Thanks to their unique "easy-to-use" features, centrifugal microfluidic platforms are potential successful candidates for the downscaling of chromatographic separation of radioactive samples (automation, multiplexing, easy integration in glove-boxes environment, and low cost of maintenance).

Production of antimicrobial silver nanoparticles modified by alkanethiol self‐assembled monolayers by direct current atmospheric pressure glow discharge generated in contact with a flowing liquid anode

“…Moreover, intense peaks were observed in the range 1,490–1,240 cm −1 and were related to stretching vibrations of the C–N group (the amide III band) . Absorption bands identified at 2,922 and 2,852 cm −1 were associated with stretching vibrations of the C–H group . Not surprisingly, rocking vibrations of –CH 3 group and wagging vibrations of the –CH 2 group were also identified .…”

“…Considering ATR FT‐IR spectra of Solution I and Solution III , it was noted that these spectra were quite similar (see Figure and Table ). Absorption bands identified at 3,343 and 3,366 cm −1 were related to the stretching vibrations of the N–H group . In addition, further bands observed at 1,653 and 1,661 cm −1 were related to N–H in plane bending vibrations (amide II band) .…”

On-chip electrochemical detection of glucose towards the miniaturised quality control of carbohydrate-based radiotracers

“…18 F]FDG and other carbohydrate-based radiotracers. 29 This technique is expected to feature a monolithic HPLC column [30][31][32][33][34][35][36][37][38] for the SAX separation since silica monoliths can be generated in microfluidic channels 39 via the sol-gel method, and both our group 27,40 and others [41][42][43][44] have employed them for radiochemical processes. We have previously demonstrated several potential radiometric detection methods that could be applied to the module, 27,28,45 including one in combination with a monolith.…”

Misbehavior detection and efficient revocation within VANET

“…Moreover, a sufficient resolution to obtained purified fraction of each radionuclide is needed. For radiochemical application in acidic media, two routes were considered: filling of the microchannels by particles [62] or a stationary phase synthesized in -situ [6,84,85].…”