Photocatalytic Late-stage Functionalization of Dehydroalanine-derived Peptides in Batch and Flow
Nikolaos Kaplaneris,
Merve Akdeniz,
Méritxell Fillols
et al.
Abstract:Unnatural amino acids, and their synthesis via the late-stage functionalization (LSF) of peptides, play a crucial role in areas such as drug design and discovery. Historically, the LSF of biomolecules has predominantly utilized traditional synthetic methodologies that exploit nucleophilic residues, such as cysteine, lysine or tyrosine. In this study, we present a photocatalytic hydroarylation process targeting the electrophilic residue dehydroalanine (Dha). This residue possesses an α,β-unsaturated moiety and … Show more
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